Joao Ascensao
@joaoascensao.bsky.social
Postdoc @ Harvard with Michael Desai | Evolutionary dynamics
ocf.berkeley.edu/~joaoascensao
ocf.berkeley.edu/~joaoascensao
Because N^2-scaling abundance fluctuations are common across populations, we also think that decoupling noise may be ubiquitous. For example, we also find signatures of decoupling noise in the barcoded yeast experiments from the Petrov and Sherlock lab
February 28, 2024 at 10:38 PM
Because N^2-scaling abundance fluctuations are common across populations, we also think that decoupling noise may be ubiquitous. For example, we also find signatures of decoupling noise in the barcoded yeast experiments from the Petrov and Sherlock lab
So what is the cause of these fluctuations?
We cultured replicates and tracked the populations over a 24 hour cycle. The replicates exponentially diverge from each other! This is the signature of chaotic dynamics—small differences between replicates are exponentially amplified
We cultured replicates and tracked the populations over a 24 hour cycle. The replicates exponentially diverge from each other! This is the signature of chaotic dynamics—small differences between replicates are exponentially amplified
February 28, 2024 at 10:37 PM
So what is the cause of these fluctuations?
We cultured replicates and tracked the populations over a 24 hour cycle. The replicates exponentially diverge from each other! This is the signature of chaotic dynamics—small differences between replicates are exponentially amplified
We cultured replicates and tracked the populations over a 24 hour cycle. The replicates exponentially diverge from each other! This is the signature of chaotic dynamics—small differences between replicates are exponentially amplified
How do we explain this?
We developed a flexible model that can account for the scaling behaviors. Uncorrelated offspring number fluctuations causes classical genetic drift. In contrast, correlated offspring number fluctuations cause ~N^2-scaling abundance fluctuations.
We developed a flexible model that can account for the scaling behaviors. Uncorrelated offspring number fluctuations causes classical genetic drift. In contrast, correlated offspring number fluctuations cause ~N^2-scaling abundance fluctuations.
February 28, 2024 at 10:35 PM
How do we explain this?
We developed a flexible model that can account for the scaling behaviors. Uncorrelated offspring number fluctuations causes classical genetic drift. In contrast, correlated offspring number fluctuations cause ~N^2-scaling abundance fluctuations.
We developed a flexible model that can account for the scaling behaviors. Uncorrelated offspring number fluctuations causes classical genetic drift. In contrast, correlated offspring number fluctuations cause ~N^2-scaling abundance fluctuations.
Under classical genetic drift, the frequency variance should scale linearly with the mean. Instead, we saw a power-law relationship, with the variance scaling like the mean squared.
February 28, 2024 at 10:35 PM
Under classical genetic drift, the frequency variance should scale linearly with the mean. Instead, we saw a power-law relationship, with the variance scaling like the mean squared.
It all started with our barcoded timecourses of a simple microbial population—we noticed huge frequency fluctuations. These populations live in a daily dilution culture, so we thought bottlenecking should drive noise. But the noise was orders of magnitude larger than expected!
February 28, 2024 at 10:33 PM
It all started with our barcoded timecourses of a simple microbial population—we noticed huge frequency fluctuations. These populations live in a daily dilution culture, so we thought bottlenecking should drive noise. But the noise was orders of magnitude larger than expected!