Joachim Brenneisen
joa1999.bsky.social
Joachim Brenneisen
@joa1999.bsky.social
Doctoral researcher at University of Freiburg, interested in regulation of autophagy on the molecular level
Reposted by Joachim Brenneisen
Reposted by Joachim Brenneisen
Physical principles have redefined our understanding of autophagy.

In our new @cp-trendsbiochem.bsky.social review, we discuss how phase separation, avidity, and wetting shape autophagy at the molecular level.

Great collaboration with @wilflinglab.bsky.social

www.cell.com/trends/bioch...
Autophagy regulation by phase separation, avidity, and wetting
Autophagy enables cells to selectively degrade a wide range of macromolecules, and how this process achieves spatial precision within the densely packed cytosol is an active area of investigation. Rec...
www.cell.com
November 20, 2025 at 1:34 PM
Reposted by Joachim Brenneisen
Congratulations! Our SFB 1381 Principal Investigator Claudine Kraft has been awarded an esteemed ERC Synergy Grant, along with her partners in Vienna and Berkeley.
November 7, 2025 at 8:52 AM
Reposted by Joachim Brenneisen
🚨 Paper Alert! We’re starting off the year with our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation!
This work was a close and exciting collaboration with
@wilflinglab.bsky.social

🔗 nature.com/articles/s41...
Here's a thread👇
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology
Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...
nature.com
January 7, 2025 at 10:30 AM