The efficacy of non-invasive brain stimulation in ameliorating schizophrenia’s negative symptoms remains to be validated. The mesocortical pathway, mostly comprising the ventral tegmental area (VTA) and prefrontal cortex, is the core neural circuit underlying negative symptoms. This study aimed to assess the clinical and biological effects of accelerated intermittent theta burst stimulation (iTBS) targeted to the dorsolateral prefrontal cortex (dlPFC), guided by personalised dlPFC-VTA functional connectivity (FC).

Cognitive deficits are a critical concern in major depressive disorder (MDD), affecting learning, memory (short- and long-term), attention, concentration, executive function, and processing speed [1]....

The quest for non-invasive, effective, and safe pain relief methods has driven extensive research. The sensorimotor cortex (SM1) is essential for pain localization, processing signals from the thalamu...

The biological mechanisms of rehabilitation after stroke are not fully understood. Here authors identify parvalbumin interneurons as a key mediator of rehabilitation-induced stroke recovery and a drug...