Joseph Castellano
@jmcastell.bsky.social
Associate Professor & PI (castellanolab.org)
@SinaiBrain / @IcahnMountSinai, Neuroscientist studying blood to brain communication in aging and Alzheimer's disease
@SinaiBrain / @IcahnMountSinai, Neuroscientist studying blood to brain communication in aging and Alzheimer's disease
Pinned
Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity - Mole...
Molecular Psychiatry - Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity
www.nature.com
Our study is out! TIMP2, prev tied to blood-borne revitalization of aged brain, regulates hippocampal plasticity via the extracellular matrix. Great teamwork f/ 1st-author Catarina Ferreira + the whole lab, +collaborators Tim Ahfeldt, Merina Varghese, and Patrick Hof!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joseph Castellano
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
September 4, 2025 at 4:32 PM
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Excited to share a new preprint out from the lab (www.biorxiv.org/content/10.1...) by 1st-author Brittany Hemmer, a newly minted PhD from the lab! A brief thread on what we found (1/n):
Youth-associated protein TIMP2 alters microglial state and function in the context of aging
There is little understanding of how aging serves as the strongest risk factor for several neurogenerative diseases. Specific neural cell types, such as microglia, undergo age-related maladaptive chan...
www.biorxiv.org
June 13, 2025 at 9:28 PM
Excited to share a new preprint out from the lab (www.biorxiv.org/content/10.1...) by 1st-author Brittany Hemmer, a newly minted PhD from the lab! A brief thread on what we found (1/n):
🎉Thrilled to announce that my awesome PhD student, @brittany_hemmer , successfully defended her thesis! Her thesis work is now preprinted (brief summary to follow)—proud of her hard work and perseverance!
June 13, 2025 at 9:11 PM
🎉Thrilled to announce that my awesome PhD student, @brittany_hemmer , successfully defended her thesis! Her thesis work is now preprinted (brief summary to follow)—proud of her hard work and perseverance!
Reposted by Joseph Castellano
Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social!
Registration 🔗 us02web.zoom.us/meeting/regi...
#NewVisionResearch #ProfessionalDevelopment
Registration 🔗 us02web.zoom.us/meeting/regi...
#NewVisionResearch #ProfessionalDevelopment
April 17, 2025 at 10:25 PM
Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social!
Registration 🔗 us02web.zoom.us/meeting/regi...
#NewVisionResearch #ProfessionalDevelopment
Registration 🔗 us02web.zoom.us/meeting/regi...
#NewVisionResearch #ProfessionalDevelopment
Reposted by Joseph Castellano
Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration
Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.
Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.
us02web.zoom.us
April 10, 2025 at 3:43 PM
Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration
Reposted by Joseph Castellano
Fantastic talks at #CCAD2025 Reunion Conference! @sinaibrain.bsky.social @jmcastell.bsky.social, Panos Roussos and Kuan-Lin Huang
April 9, 2025 at 6:12 PM
Fantastic talks at #CCAD2025 Reunion Conference! @sinaibrain.bsky.social @jmcastell.bsky.social, Panos Roussos and Kuan-Lin Huang
Reposted by Joseph Castellano
Our latest in PNAS! 🎉
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate
fluctuations are a biomarker of sleep/wake transitions, where in...
www.pnas.org
February 18, 2025 at 7:48 PM
Our latest in PNAS! 🎉
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
Reposted by Joseph Castellano
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
December 18, 2024 at 10:40 PM
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Reposted by Joseph Castellano
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Neuroscience methods - YouTube
Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...
www.youtube.com
December 13, 2024 at 11:33 AM
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Reposted by Joseph Castellano
Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome
These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).
Open Access
www.cell.com/cell/fulltex...
These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).
Open Access
www.cell.com/cell/fulltex...
November 25, 2024 at 12:56 AM
Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome
These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).
Open Access
www.cell.com/cell/fulltex...
These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com).
Open Access
www.cell.com/cell/fulltex...
Reposted by Joseph Castellano
Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added!
go.bsky.app/5UXXaDA
go.bsky.app/5UXXaDA
November 23, 2024 at 4:15 PM
Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added!
go.bsky.app/5UXXaDA
go.bsky.app/5UXXaDA
Reposted by Joseph Castellano
Hello Bluesky! 🦋 I’m an Associate Professor of #Neuroscience at the Icahn School of Medicine at Mount Sinai. I study how memories are stably stored and flexibly updated across time and experience 🧠 I also develop open-source tech!
Looking forward to connecting here! #Neuroskyence #WomenInSTEM
Looking forward to connecting here! #Neuroskyence #WomenInSTEM
November 15, 2024 at 7:37 PM
Hello Bluesky! 🦋 I’m an Associate Professor of #Neuroscience at the Icahn School of Medicine at Mount Sinai. I study how memories are stably stored and flexibly updated across time and experience 🧠 I also develop open-source tech!
Looking forward to connecting here! #Neuroskyence #WomenInSTEM
Looking forward to connecting here! #Neuroskyence #WomenInSTEM
Reposted by Joseph Castellano
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
November 14, 2024 at 3:21 AM
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
Our study is out! TIMP2, prev tied to blood-borne revitalization of aged brain, regulates hippocampal plasticity via the extracellular matrix. Great teamwork f/ 1st-author Catarina Ferreira + the whole lab, +collaborators Tim Ahfeldt, Merina Varghese, and Patrick Hof!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity - Mole...
Molecular Psychiatry - Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity
www.nature.com
November 2, 2023 at 3:56 PM
Our study is out! TIMP2, prev tied to blood-borne revitalization of aged brain, regulates hippocampal plasticity via the extracellular matrix. Great teamwork f/ 1st-author Catarina Ferreira + the whole lab, +collaborators Tim Ahfeldt, Merina Varghese, and Patrick Hof!
www.nature.com/articles/s41...
www.nature.com/articles/s41...