Jan Mathony
@jmathony.bsky.social
Scientist with a passion for Synbio | Protein engineering | Optogenetics | ML
www.niopeklab.de/mathony-lab/
www.niopeklab.de/mathony-lab/
🎉🎉 congrats Michael!!
September 24, 2025 at 4:35 PM
🎉🎉 congrats Michael!!
Happy to hear that, thank you!
August 22, 2025 at 6:55 AM
Happy to hear that, thank you!
Congrats Michael, great work as always!
June 20, 2025 at 6:10 AM
Congrats Michael, great work as always!
Find a longer thread about our work here:
bsky.app/profile/niop...
bsky.app/profile/niop...
Inspired by how nature evolves trigger responsiveness through alternating pressures, we are excited to present POGO-PANCE and RAMPhaGE:
Phage-assisted evolution platforms for engineering allosteric protein switches under dynamic selection.
Preprint: doi.org/10.1101/2025...
Phage-assisted evolution platforms for engineering allosteric protein switches under dynamic selection.
Preprint: doi.org/10.1101/2025...
Phage-Assisted Evolution of Allosteric Protein Switches
Allostery, the transmission of locally induced conformational changes to distant functional sites, is a key mechanism for protein regulation. Artificial allosteric effectors enable remote manipulation...
doi.org
June 13, 2025 at 2:12 PM
Find a longer thread about our work here:
bsky.app/profile/niop...
bsky.app/profile/niop...
The link above seems to be broken, so here is the actual link to the paper: www.biorxiv.org/content/10.1...
Modular Engineering of Thermo-Responsive Allosteric Proteins
Thermogenetics enables non-invasive spatiotemporal control over protein activity in living cells and tissues, yet its applications have largely been restricted to transcriptional regulation and membra...
www.biorxiv.org
May 3, 2025 at 8:49 PM
The link above seems to be broken, so here is the actual link to the paper: www.biorxiv.org/content/10.1...
Huge congrats to all authors, especially to co-first authors @ann-sophiekroell.bsky.social and Kira Hoffmann, who did an outstanding job!
May 3, 2025 at 11:03 AM
Huge congrats to all authors, especially to co-first authors @ann-sophiekroell.bsky.social and Kira Hoffmann, who did an outstanding job!
In line with recent work by Bugaj and colleagues, who pioneered the thermal programming of protein localization and signaling using BcLOV4 (www.nature.com/articles/s41...), our result highlight LOV domains as versatile thermoreceptors.
Precision control of cellular functions with a temperature-sensitive protein - Nature Methods
Temperature-sensitive proteins would enable the remote control of cellular functions deep within tissues, although few such proteins have been characterized. Melt is a protein that reversibly clusters...
www.nature.com
May 3, 2025 at 11:03 AM
In line with recent work by Bugaj and colleagues, who pioneered the thermal programming of protein localization and signaling using BcLOV4 (www.nature.com/articles/s41...), our result highlight LOV domains as versatile thermoreceptors.
Finally, we also show efficient thermal protein control using another (chemo-)receptor domain as insert. Our work expands thermogenetics to the allostreric control of proteins.
May 3, 2025 at 11:03 AM
Finally, we also show efficient thermal protein control using another (chemo-)receptor domain as insert. Our work expands thermogenetics to the allostreric control of proteins.
The insertion of our LOV2 variants into transcription factors, Cas9 and an RNA-binding protein enables the thermogenetic control of various cellular processes. We expect the approach to be easily tranferrable to the various AsLOV2-based tools out there.
May 3, 2025 at 11:03 AM
The insertion of our LOV2 variants into transcription factors, Cas9 and an RNA-binding protein enables the thermogenetic control of various cellular processes. We expect the approach to be easily tranferrable to the various AsLOV2-based tools out there.
It was a pleasure to meet all of you and discuss science! Many thanks again for the invitation.
April 22, 2025 at 3:17 PM
It was a pleasure to meet all of you and discuss science! Many thanks again for the invitation.