🚨 New preprint out!

www.biorxiv.org/content/10.1...

We introduce a framework that maps convergent (positive) and divergent (negative) spatial topographies of individualized brain networks—and reveals how these network interactions invert in newborns and reorganize across development.

Thread 🧵 ⬇️

🚨 New Preprint 🚨

Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects

By Cyr et al.

***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?

A: Yes!

🧵:

I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social

AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...

doi.org/10.1038/s415...

We have argued that the brain’s Action Mode Network controls functions required for goal-directed behavior. www.nature.com/articles/s41...

Now, in new work, we show that AMN contains distinct subnetworks for making decisions, implementing actions, and processing feedback. doi.org/10.1073/pnas...

How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...

Alert! ... for the child development world!

@fluxsociety.bsky.social @fitngin.bsky.social ‪

The Healthy Brain and Child Development (HBCD) Study has released its first data wave - it’s massive.

Check here:
docs.hbcdstudy.org

and here:
nbdc-datahub.org

Here’s why it matters 🧠🍼

Alert!!!!

“An Action Networks Model for Pain”

We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.

👉 thread below 🧵

osf.io/preprints/ps...

When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...

👏

White matter microstructure and macrostructure brain charts across the human lifespan | bioRxiv www.biorxiv.org/content/10.1...

It turns out the brain🧠is silently🤫working when your arm is in a cast. 🩼 🚧
Plastic changes occur, and revert again when the cast is removed … not just in cortex.

Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!!

Out at @natcomms.nature.com:
www.nature.com/articles/s41...

It's shocking how little is known about the brainstem red nucleus. In our new paper “The human brainstem’s red nucleus was upgraded to support goal-directed action” out now in @naturecomms.bsky.social we show that current thinking on the red nucleus is in need of a serious upgrade. rdcu.be/ehbOy

Happy to share that our article “Human lifespan changes in the brain’s functional connectome” is now published online at Nature Neuroscience @natureneuro.bsky.social !

Many thanks to all collaborators & data contributors, and the editor team & reviewers!

www.nature.com/articles/s41...

New paper out today in PNAS 🎉 demonstrating:
1) an association between social disadvantage & child brain function can be observed as early as birth
2) these alterations are brain-wide, but most pronounced in functional networks & subcortex later linked to childhood adversity

doi.org/10.1073/pnas...

My favorite recent read has been this @natureportfolio.bsky.social N&V by Roselyne Chauvin and @ndosenbach.bsky.social summarizing and contextualizing @kaidikang.bsky.social et als' study describing the features that contribute to reproducible BWAS studies 🧪 www.nature.com/articles/d41...