Jan-Hannes Schaefer
@jhschaef.bsky.social
Structural Biology to the rescue. Postdoc with Gabriel Lander at Scripps Research. PhD with Arne Moeller. #cryoEM ❄️🔬 🎹⛳
I'll try and keep you updated. The story continues.
October 5, 2025 at 6:17 PM
I'll try and keep you updated. The story continues.
@maxewilkinson.bsky.social fun little cryo-EM puzzle. I am still pushing the resolution to let ModelAngelo do its magic. My guess was either a common amyloid binder like SAP or an intermediate of Lysozyme-amyloids...
October 5, 2025 at 5:27 PM
@maxewilkinson.bsky.social fun little cryo-EM puzzle. I am still pushing the resolution to let ModelAngelo do its magic. My guess was either a common amyloid binder like SAP or an intermediate of Lysozyme-amyloids...
Thanks @olibclarke.bsky.social I must have overlooked that one and should give it a go.
October 5, 2025 at 1:58 PM
Thanks @olibclarke.bsky.social I must have overlooked that one and should give it a go.
Reprocessed ALys Amyloids from EMPIAR-11785 Fändrich Lab
October 5, 2025 at 4:24 AM
Reprocessed ALys Amyloids from EMPIAR-11785 Fändrich Lab
CS workflow for easy testing: github.com/schaefer-jh/...
GitHub - schaefer-jh/CS-amyloids: Amyloid-processing with cryo-SPARC
Amyloid-processing with cryo-SPARC. Contribute to schaefer-jh/CS-amyloids development by creating an account on GitHub.
github.com
October 5, 2025 at 4:19 AM
CS workflow for easy testing: github.com/schaefer-jh/...
Congrats @olibclarke.bsky.social, great work. I've tried PKA and failed. SPA processing is still an art and lesson in persistence.
September 13, 2025 at 5:53 AM
Congrats @olibclarke.bsky.social, great work. I've tried PKA and failed. SPA processing is still an art and lesson in persistence.
I often go back to this striking study: doi.org/10.1126/scie...
September 4, 2025 at 1:18 AM
I often go back to this striking study: doi.org/10.1126/scie...
Thanks for sharing @olibclarke.bsky.social. I wonder if many more "hollow" complexes are co-purified with binding-partners. Let's all put more datasets on EMPIAR to revisit processing with new creative approaches like Oli's.
September 1, 2025 at 4:50 PM
Thanks for sharing @olibclarke.bsky.social. I wonder if many more "hollow" complexes are co-purified with binding-partners. Let's all put more datasets on EMPIAR to revisit processing with new creative approaches like Oli's.
Congrats @olibclarke.bsky.social and team. Such a great idea! Would you share some more CS parameters for the processing-geeks? Maybe via a CS workflow .json?
August 31, 2025 at 3:23 AM
Congrats @olibclarke.bsky.social and team. Such a great idea! Would you share some more CS parameters for the processing-geeks? Maybe via a CS workflow .json?