James Herbort
@jhhchem.bsky.social
Merck PR&D, Ohio native, coffee enthusiast☕
Reposted by James Herbort
So excited to see this published! Thionucleosides can be incredibly challenging to make due to the need for oxidation state changes at sulfur during the synthesis. Collaborating with the Britton group, we’ve been able to make them using a short, selective sequence!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
A flexible and scalable synthesis of 4′-thionucleosides
4′-Thionucleosides (thNAs) are synthetic nucleoside analogues that have attracted attention as leads for drug discovery in oncology and virology. Here we report a de novo thNA synthesis that relies on...
pubs.rsc.org
November 27, 2024 at 7:07 PM
So excited to see this published! Thionucleosides can be incredibly challenging to make due to the need for oxidation state changes at sulfur during the synthesis. Collaborating with the Britton group, we’ve been able to make them using a short, selective sequence!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
