Our laboratory contributed to this work by resolving acidic patch-binding nanobodies developed by @epicypher.bsky.social. I’d like to thank our wonderful collaborators, and Emma Saccone (@emmasaccone.bsky.social)(data analysis, interprt., figs) and Heather Folkwein (@hjf3.bsky.social)(sample prep)

This work highlights a delicate balance between nucleosome acidic patch interactors critical for normal cellular functions and dysregulated in disease