Jessica Lu
@jessicajlu.bsky.social
Postdoc at Ranes Lab, Oxford Biochemistry | Formerly at MIPS DDB | Cryo-EM, molecular pharmacology, GPCRs and Frizzled receptors.
Reposted by Jessica Lu
Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing pubmed.ncbi.nlm.nih.gov/41264251/ #cryoem
November 21, 2025 at 7:40 PM
Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing pubmed.ncbi.nlm.nih.gov/41264251/ #cryoem
Reposted by Jessica Lu
Job Alert 🔊🔊
Looking for a Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential. Deadline 15 Dec. tinyurl.com/Wnt-signalling
Looking for a Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential. Deadline 15 Dec. tinyurl.com/Wnt-signalling
Postdoctoral Research Associate in Mechanisms of Cell Signalling at University of Oxford
An opportunity for an academic position as a Postdoctoral Research Associate in Mechanisms of Cell Signalling is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openin...
tinyurl.com
November 21, 2025 at 10:36 PM
Job Alert 🔊🔊
Looking for a Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential. Deadline 15 Dec. tinyurl.com/Wnt-signalling
Looking for a Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential. Deadline 15 Dec. tinyurl.com/Wnt-signalling
Reposted by Jessica Lu
Come see me in Chicago for AACR 2025 to talk about GPR68, both our take on the state of the target and its purported chemical space, and the really cool data we're showing for the first time. Two posters!
Recursion at AACR: 2 of our posters at #AACR25 April 25-30 in Chicago will highlight the characterization of our potential first-in-class GPR68 antagonists in preclinical development for oncology indications & how they compare favorably to other inhibitors. www.abstractsonline.com/pp8/#!/20273
March 26, 2025 at 2:35 PM
Come see me in Chicago for AACR 2025 to talk about GPR68, both our take on the state of the target and its purported chemical space, and the really cool data we're showing for the first time. Two posters!
Reposted by Jessica Lu
Roche's open-source gift to the world of GPCRs and structural biology: scFv16. I wasn't aware of this history until Mazdak wrote it up...
scFv16: The Unsung Heroes Behind a Critical Tool for GPCR Research
scFv16 has transformed GPCR research, enabling routine cryo-EM structure determination. Discover how Roche’s decision to make it open-access is driving innovation in drug discovery.
cryoduck.com
March 7, 2025 at 6:01 PM
Roche's open-source gift to the world of GPCRs and structural biology: scFv16. I wasn't aware of this history until Mazdak wrote it up...
Reposted by Jessica Lu
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways - Nature Communications
GPCR dynamics are critical for signal transmission into the cell. Here, the authors probe receptor plasticity using molecular dynamics simulations, enabling the detection of allosteric sites and drug ...
www.nature.com
March 2, 2025 at 9:18 AM
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
www.nature.com/articles/s41...
www.nature.com/articles/s41...