Jesse
@jessetoenjes.bsky.social
PhD Student at the Kuemmel Lab.
University Münster
University Münster
Reposted by Jesse
Thrilled to share our newest publication in Science Advances!
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
The molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks.
www.science.org
September 2, 2025 at 8:02 PM
Thrilled to share our newest publication in Science Advances!
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
Reposted by Jesse
Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned https://www.biorxiv.org/content/10.1101/2025.03.27.645700v1
March 29, 2025 at 4:46 AM
Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned https://www.biorxiv.org/content/10.1101/2025.03.27.645700v1