Henning Jessen
@jessenlab.bsky.social
Reposted by Henning Jessen
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism-based 1,2,3-triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP-ribose (ADPR) adducts from...
onlinelibrary.wiley.com
November 2, 2025 at 1:20 PM
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
because he only exhaled... must go wrong ; 12 years is quite impressive!
June 23, 2025 at 1:23 PM
because he only exhaled... must go wrong ; 12 years is quite impressive!
Hi, it would be great if you can add me to the list! I am running a group in biological chemistry; here is a link to my orcid account. Thanks!
orcid.org/0000-0002-10...
orcid.org/0000-0002-10...
ORCID
orcid.org
November 19, 2024 at 9:42 AM
Hi, it would be great if you can add me to the list! I am running a group in biological chemistry; here is a link to my orcid account. Thanks!
orcid.org/0000-0002-10...
orcid.org/0000-0002-10...