Jenn Sydeski (Health Tech ✚🧬 Jenn)
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jennifersydeski.com
Jenn Sydeski (Health Tech ✚🧬 Jenn)
@jennifersydeski.com
2.7K followers 350 following 170 posts
🌱Be the helpers, friends! Mr. Rogers is looking for you🌿

💙 Health Tech 🩻 Life Sciences 🧬🧪 AI 🤖 VR ᯅ Accessibility Advocacy ♿ Community Medical Care ⛑️ Mutual Aid 🤝 Supporting Moms 🦋 Nerdfighteria 🖖 Pittsburgh 🩵 www.jennifersydeski.com
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jennifersydeski.com
Doing a year-in review and looking for something totally else, but just found one of my favorite podcast experiences from back in my #ConnectWolf days with Mitch Turck 😍

share.transistor.fm/s/2b920ea3
December 7, 2025 at 2:48 PM
jennifersydeski.com
$3000k perks $5250 Perks $10k perks $20,000 perks
August 11, 2025 at 3:51 PM
jennifersydeski.com
$100 to be a tech investor 💫
Or more for bigger perks! 🌈

Brad and I at @ektovr.bsky.social are inviting our community to join in as an EKTO investor before our big consumer launch at #PAX this month 🩵
$100 perks $500 Perks $1200 perks $3000 perks
August 11, 2025 at 3:50 PM
jennifersydeski.com
TL;DR 💙 Touchin grass n'at 🌿 Toodles! ✌️
🧵@pittsburghai.bsky.social L;R Thanks for doing stuff with me! PGH.AI’s off to a strong repeatable start, Sheetz inno-infrastructure is deployed and we just got some major innovation props, @ektovr.bsky.social's commercialization launch is set up and running,
cute dog
May 21, 2025 at 5:44 PM
jennifersydeski.com
Personalized ctDNA testing shows promise in detecting minimal residual disease in metastatic invasive lobular carcinoma, offering a potential tool for early relapse detection and treatment monitoring.

ascopubs.org/doi/10.1200/...
1. Feasibility of Personalized ctDNA Testing: The study demonstrates that personalized ctDNA assays can be developed and are feasible for monitoring metastatic ILC. 2. Early Detection of Relapse: ctDNA levels were found to rise before clinical or radiographic evidence of disease progression, indicating potential for early relapse detection. 3. Correlation with Treatment Response: Changes in ctDNA levels correlated with treatment responses, suggesting utility in monitoring therapeutic efficacy. 4. Potential for Personalized Monitoring: This approach underscores the potential of ctDNA testing as a personalized tool for disease monitoring in metastatic ILC patients.
May 19, 2025 at 3:35 PM
jennifersydeski.com
@pittsburghai.bsky.social booth at #Pittsburgh #Product Camp

(Thanks to @ektovr.bsky.social for the equipment! 😘)
PGH.ai group
May 17, 2025 at 4:45 PM
jennifersydeski.com
@pittsburghai.bsky.social booth at #Pittsburgh #Product Camp

(Thanks to @ektovr.bsky.social for the equipment! 😘)
May 17, 2025 at 4:44 PM
jennifersydeski.com
AI-driven research reveals that the enzyme PHGDH, beyond its known metabolic role, acts as a transcriptional regulator promoting amyloid pathology in Alzheimer's disease. Targeting this function offers a promising therapeutic avenue.

www.cell.com/cell/fulltex...
1. PHGDH's Dual Role: Traditionally recognized for its metabolic functions, PHGDH also regulates gene expression, influencing Alzheimer's disease progression. 2. AI-Powered Discovery: Utilizing AI, researchers identified PHGDH's structural similarity to transcription factors, unveiling its unexpected role in gene regulation. 3. Therapeutic Potential: Inhibiting PHGDH's transcriptional activity with a blood-brain barrier-permeable molecule reduced amyloid pathology in preclinical models. 4. Beyond Genetic Mutations: This finding highlights a non-genetic contributor to Alzheimer's, offering new hope for treatments targeting sporadic cases.
May 17, 2025 at 1:45 AM
jennifersydeski.com
In a world-first, doctors used CRISPR to correct a deadly genetic mutation inside a baby's liver, offering hope for treating rare diseases with personalized gene editing.

www.npr.org/sections/sho...
1. First In-Body CRISPR Treatment: Doctors successfully edited DNA inside a living patient, a baby with CPS1 deficiency, marking a significant medical milestone. 2. Rapid Development: The custom therapy was developed and approved in just six months, showcasing the potential for swift responses to rare genetic conditions. 3. Improved Health Outcomes: Post-treatment, the baby showed remarkable health improvements, including better protein tolerance and immune response. 4. Future of Personalized Medicine: This case paves the way for bespoke gene-editing therapies, potentially transforming treatment for countless rare genetic disorders.
May 15, 2025 at 11:07 PM
jennifersydeski.com
The #FDA is rapidly implementing #AI across all centers by June 30, 2025, following a successful pilot that enhanced scientific review efficiency, aiming to expedite therapy evaluations and reduce administrative burdens.

How do we feel about this?

oncodaily.com/insight/fda-...
1. Agency-Wide AI Integration: The FDA plans to deploy a unified, secure generative AI system across all centers by June 30, 2025, to streamline internal workflows. 2. Efficiency Gains from Pilot: A recent AI pilot demonstrated significant improvements in scientific review processes, prompting the accelerated rollout. 3. Leadership Endorsement: FDA Commissioner Martin Makary emphasized the importance of valuing scientists' time and reducing non-productive tasks through AI. 4. Focus on Therapeutic Acceleration: The initiative aims to expedite the evaluation of new therapies, benefiting patients by bringing treatments to market more swiftly.
May 14, 2025 at 4:22 AM
jennifersydeski.com
Scientists have developed a non-invasive method to 3D print tissues inside the body using ultrasound and a special bioink, eliminating the need for surgery and opening new avenues for internal tissue repair and drug delivery.

singularityhub.com/2025/05/12/s...
1. Ultrasound-Activated Bioink: A new bioink remains liquid at body temperature but solidifies into desired structures when exposed to focused ultrasound, enabling precise internal tissue formation. 2. Non-Invasive Internal Printing: This technique allows for the creation of tissues, biosensors, and drug depots directly inside organs without surgical intervention, reducing risks and recovery time. 3. Real-Time Monitoring: The bioink includes components that respond to ultrasound, allowing scientists to monitor the printing process in real-time and ensure accurate placement. 4. Versatile Applications: Beyond tissue repair, this method has potential uses in targeted drug delivery and the creation of internal biosensors, marking a significant advancement in regenerative medicine.
May 13, 2025 at 4:05 PM
jennifersydeski.com
May 13, 2025 at 2:10 AM
jennifersydeski.com
Researchers detected #measles virus in Houston #wastewater in early January 2025, ten days before clinical cases were reported, demonstrating wastewater sequencing as a powerful #earlywarning tool for #infectiousdisease #outbreaks.

ajph.aphapublications.org/doi/epdf/10....
1. Early Detection via Wastewater Sequencing: Measles virus was identified in wastewater samples on January 7, 2025, preceding confirmed clinical cases by ten days, showcasing the potential of wastewater surveillance for early outbreak detection. 2. High Sensitivity and Specificity: The sequencing-based method proved highly sensitive, detecting measles RNA in wastewater where no cases had been reported for over 31 months, and was validated through PCR testing. 3. Correlation with Clinical Cases: The presence of measles in wastewater corresponded with two infected travelers residing in the area, indicating the method's effectiveness in reflecting real-time community infections. 4. Public Health Implications: This approach offers a non-invasive, community-wide surveillance tool that can inform public health responses and interventions ahead of clinical case confirmations.
May 13, 2025 at 12:29 AM
jennifersydeski.com
Political shifts in the U.S. are threatening mRNA research, with funding cuts and anti-vaccine sentiments endangering advancements in cancer, HIV, and rare disease treatments.

www.nature.com/articles/d41...
May 12, 2025 at 12:40 PM
jennifersydeski.com
New data shows the shingles vaccine may reduce dementia risk by up to 20%, especially in women. While the exact mechanism is unclear, the immune response to vaccination appears protective. A promising twofer: prevent shingles and lower dementia risk.
erictopol.substack.com/p/the-shingl...
May 12, 2025 at 4:00 AM
jennifersydeski.com
Two very solid books and heckin relevant.

John Green
@johngreensbluesky.bsky.social #everythingistuberculosis
Michael Lewis
@michaellewis65.bsky.social #whoisgovernment
Michael Lewis #whoisgovernment John Green #everythingistuberculosis
April 5, 2025 at 12:06 AM
jennifersydeski.com
All cruelty springs from hate. -Seneca
March 23, 2025 at 2:37 AM
jennifersydeski.com
Happy Spring ☔🌱🌸🌷
The Northern hemisphere will start tilting towards the Sun! ☀️
Equinox and summer solstice
March 20, 2025 at 5:03 AM
jennifersydeski.com
🥗😘
Beware the Ides of March
March 15, 2025 at 6:24 PM
jennifersydeski.com
Beware the Ides of March 🥗😘
Caesar messed up the calendar
March 15, 2025 at 6:22 PM
jennifersydeski.com
One of my favorite true nerd stories 🩵
Nerds being awkward 🩵
March 14, 2025 at 1:38 AM
jennifersydeski.com
FDA just cleared the ReWalk 7, the latest in Lifeward’s lineup of wearable exoskeletons for spinal cord injury. More features, more accessibility, and backed by Medicare. #MedTech

https://www.globenewswire.com/news-release/2025/03/13/3042267/0/en/FDA-Issues-Clearance-for-ReWalk-7-Exoskeleton.html
March 13, 2025 at 2:59 PM
jennifersydeski.com
I missed it by a few minutes, but my buddy and I celebrated by hitting up an arcade for half an hour and watching some Gaming Historian videos 🎮🕹️ Happy Mar10 Day 😘
March 11, 2025 at 4:27 AM
jennifersydeski.com
Neffy is an epinephrine nose spray for allergic reactions like anaphylaxis and just got approved by the FDA for kids 💊💉💦

https://www.pharmacytimes.com/view/fda-approves-neffy-1-mg-for-type-1-allergic-reactions-including-anaphylaxis-in-children
March 9, 2025 at 11:20 PM
jennifersydeski.com
Fully basking in fake spring despite the fact that winter is waiting around the corner with a baseball bat 🤣 I love seasons because after a few weeks, I'm ready for a change in the vibe.
March 9, 2025 at 8:10 PM