Jenna Whalen
jennawhalen.bsky.social
Jenna Whalen
@jennawhalen.bsky.social
Post-Doc in the Cantor Lab (@cantorlab.bsky.social) at UMass Chan Medical School.
Reposted by Jenna Whalen
Research from the Cantor Lab published in Nature Cancer poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells and identifies a potential target for therapeutics: direc.to/mNmm

@cantorlab.bsky.social @jennawhalen.bsky.social @naturecancer.bsky.social
Research by UMass Chan scientists upends scientific understanding of how anticancer drugs kill cancer
Research by Sharon Cantor, PhD, and Jenna M. Whalen, PhD, poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells.
direc.to
February 26, 2025 at 2:20 PM
Reposted by Jenna Whalen
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability
Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...
rdcu.be
January 21, 2025 at 5:26 PM