Jeffrey Pullin
@jeffreypullin.bsky.social
PhD Student, MRC Biostatistics Unit
University of Cambridge
Gates Cambridge Scholar
Bioinformatics, genetics, single-cell, statistics
Australian 🇦🇺
University of Cambridge
Gates Cambridge Scholar
Bioinformatics, genetics, single-cell, statistics
Australian 🇦🇺
The worst app I’ve ever used haha
October 22, 2025 at 6:30 PM
The worst app I’ve ever used haha
Good point! Indeed I just checked and we don't see colocalisation between IFI6 and the GWAS
October 3, 2025 at 3:25 PM
Good point! Indeed I just checked and we don't see colocalisation between IFI6 and the GWAS
Makes perfect sense! I think it's super interesting that IFI6 is the regulated gene as it has an antiviral function but is not thought to affect HHV-7
October 3, 2025 at 2:17 PM
Makes perfect sense! I think it's super interesting that IFI6 is the regulated gene as it has an antiviral function but is not thought to affect HHV-7
It's awesome isn't it! There have also been two other recent EBV viral load GWAS: www.medrxiv.org/content/10.1... and www.biorxiv.org/content/10.1...
Host control of latent Epstein-Barr virus infection
Epstein-Barr virus (EBV) is a herpes virus that infects around 90-95% of the global population, and is associated with numerous autoimmune and neoplastic diseases. EBV persists in B cells as a life-lo...
www.medrxiv.org
October 3, 2025 at 2:14 PM
It's awesome isn't it! There have also been two other recent EBV viral load GWAS: www.medrxiv.org/content/10.1... and www.biorxiv.org/content/10.1...
Great to see this out! Seeing the thumbnail reminded me that SP110 was recently identified as a GWAS hit for HHV7 viral load
www.biorxiv.org
October 2, 2025 at 1:49 PM
Great to see this out! Seeing the thumbnail reminded me that SP110 was recently identified as a GWAS hit for HHV7 viral load
Thanks for that clarification! So perhaps the challenge is really constructing accurate PGS for binary phenotypes in non-ascertained diseases?
August 25, 2025 at 10:54 AM
Thanks for that clarification! So perhaps the challenge is really constructing accurate PGS for binary phenotypes in non-ascertained diseases?
Such cool work! Do you think this work can inform optimal prior structures for trans-eQTL discovery models? That is, suggest the right amount of pooling/shrinkage over genes
August 22, 2025 at 8:16 PM
Such cool work! Do you think this work can inform optimal prior structures for trans-eQTL discovery models? That is, suggest the right amount of pooling/shrinkage over genes
Thanks for those thoughts! Plenty to consider.
August 18, 2025 at 3:10 PM
Thanks for those thoughts! Plenty to consider.
Does anyone have any intuition for why that is? And if they are so hard to construct why are we now countenancing them is high stakes contexts!? 2/2
August 18, 2025 at 1:44 PM
Does anyone have any intuition for why that is? And if they are so hard to construct why are we now countenancing them is high stakes contexts!? 2/2