Jason Fernandes
@jdfev.bsky.social
Head of Epigenetic Engineering at Scribe Therapeutics
Views are my own.
PhD: Overlapping genes w/ Alan Frankel (UCSF)
Postdoc: KZNFs w/ David Haussler (UCSC/HHMI)
Views are my own.
PhD: Overlapping genes w/ Alan Frankel (UCSF)
Postdoc: KZNFs w/ David Haussler (UCSC/HHMI)
Reposted by Jason Fernandes
Meet our team at the following events:
1️⃣ @keystonesymposia.bsky.social “Precision Genome Engineering”: Principal Scientist @jdfev.bsky.social will present a late-breaking talk “Engineering of Next Generation Epigenetic Editors for Enhanced Durable Repression in Non-Human Primates" (Tuesday 3/4)
1️⃣ @keystonesymposia.bsky.social “Precision Genome Engineering”: Principal Scientist @jdfev.bsky.social will present a late-breaking talk “Engineering of Next Generation Epigenetic Editors for Enhanced Durable Repression in Non-Human Primates" (Tuesday 3/4)
February 27, 2025 at 4:00 PM
Meet our team at the following events:
1️⃣ @keystonesymposia.bsky.social “Precision Genome Engineering”: Principal Scientist @jdfev.bsky.social will present a late-breaking talk “Engineering of Next Generation Epigenetic Editors for Enhanced Durable Repression in Non-Human Primates" (Tuesday 3/4)
1️⃣ @keystonesymposia.bsky.social “Precision Genome Engineering”: Principal Scientist @jdfev.bsky.social will present a late-breaking talk “Engineering of Next Generation Epigenetic Editors for Enhanced Durable Repression in Non-Human Primates" (Tuesday 3/4)
Reposted by Jason Fernandes
Incredible resource for DNA binding protein specificity from the Codebook consortium.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Am reading these in detail & will have a lot to say. Stay tuned for thoughts.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Am reading these in detail & will have a lot to say. Stay tuned for thoughts.
Extensive binding of uncharacterized human transcription factors to genomic dark matter
Most of the human genome is thought to be non-functional, and includes large segments often referred to as "dark matter" DNA. The genome also encodes hundreds of putative and poorly characterized tran...
www.biorxiv.org
November 13, 2024 at 6:35 PM
Incredible resource for DNA binding protein specificity from the Codebook consortium.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Am reading these in detail & will have a lot to say. Stay tuned for thoughts.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Am reading these in detail & will have a lot to say. Stay tuned for thoughts.
Reposted by Jason Fernandes
Epigenetics and chromatin crowd: What was a (or the) paper you read early on that made you think "wow, I'm in the right field". Mine is the classic on plant imprinting from Tetsuji Kakutani's group (Kinoshita et al., Science 2004) doi.org/10.1126/scie...
One-Way Control of FWA Imprinting in Arabidopsis Endosperm by DNA Methylation
The Arabidopsis FWA gene was initially identified from late-flowering epigenetic mutants that show ectopic FWA expression associated with heritable hypomethylation of repeats around transcription star...
doi.org
November 10, 2024 at 11:08 AM
Epigenetics and chromatin crowd: What was a (or the) paper you read early on that made you think "wow, I'm in the right field". Mine is the classic on plant imprinting from Tetsuji Kakutani's group (Kinoshita et al., Science 2004) doi.org/10.1126/scie...
Reposted by Jason Fernandes
I've been meaning to write a lengthy thread about our experiences with DNA methylation editing in mouse ESCs if that would be useful (or interesting?) for a niche audience here. tl;dr: it was frustrating but we learned a lot, and it ended with our shiny new pub (1/17) www.nature.com/articles/s41...
November 12, 2024 at 9:38 PM
I've been meaning to write a lengthy thread about our experiences with DNA methylation editing in mouse ESCs if that would be useful (or interesting?) for a niche audience here. tl;dr: it was frustrating but we learned a lot, and it ended with our shiny new pub (1/17) www.nature.com/articles/s41...
Reposted by Jason Fernandes
Hey newcomers! You can find the folks you followed on Twitter with this tool (it’s imperfect but useful!) skeet.labnotes.org
Skeet @ labnotes.org
Find your Twitter/Mastodon follows on BlueSky
skeet.labnotes.org
September 10, 2023 at 9:20 PM
Hey newcomers! You can find the folks you followed on Twitter with this tool (it’s imperfect but useful!) skeet.labnotes.org