Jason Wilson
@jasonwils.bsky.social
BBSRC Discovery Fellow | #CryoEM 🔬 | S-layers - Bacteriocins - Phages - GTAs | He/Him
http://mstdn.science/@JasonSWilson
http://mstdn.science/@JasonSWilson
Congrats to everyone involved, great insights and visually striking!
April 19, 2025 at 11:59 AM
Congrats to everyone involved, great insights and visually striking!
You can also read more here on the @sheffielduni.bsky.social webpage
www.sheffield.ac.uk/biosciences/...
www.sheffield.ac.uk/biosciences/...
Fighting bacteria with viruses: Important step to treating antibiotic resistant infections
New insights into a ‘friendly virus’ that could pave the way for cutting edge treatments for the potentially fatal superbug C.diff have been uncovered by University of Sheffield scientists.
www.sheffield.ac.uk
March 27, 2025 at 10:54 AM
You can also read more here on the @sheffielduni.bsky.social webpage
www.sheffield.ac.uk/biosciences/...
www.sheffield.ac.uk/biosciences/...
Lots left to figure out, and very excited to see where @robfagan.bsky.social, @perbullough.bsky.social, and Louis-Charles Fortier take this next, whilst I take on a @ukri.org BBSRC Discovery Fellowship.
March 27, 2025 at 10:54 AM
Lots left to figure out, and very excited to see where @robfagan.bsky.social, @perbullough.bsky.social, and Louis-Charles Fortier take this next, whilst I take on a @ukri.org BBSRC Discovery Fellowship.
Finally, we found that phiCD508 lacks identifiable enzymatic domains in the tail spike, suggesting the #phage breaks through by contractile force alone.
March 27, 2025 at 10:54 AM
Finally, we found that phiCD508 lacks identifiable enzymatic domains in the tail spike, suggesting the #phage breaks through by contractile force alone.
We also found that S-layer penetrating phages tend to have smaller tail spikes, lacking a beta-helical domain.
March 27, 2025 at 10:54 AM
We also found that S-layer penetrating phages tend to have smaller tail spikes, lacking a beta-helical domain.
Surprisingly, we found that phiCD508 only contracts by about 20%, which is quite unusual. It also seems a reduced contraction is conserved amongst S-layer penetrating #phages
March 27, 2025 at 10:54 AM
Surprisingly, we found that phiCD508 only contracts by about 20%, which is quite unusual. It also seems a reduced contraction is conserved amongst S-layer penetrating #phages
We were able to determine the structure of the #phage in both the extended and contracted states, and model the majority of the proteins making up the ~23MDa assembly
March 27, 2025 at 10:54 AM
We were able to determine the structure of the #phage in both the extended and contracted states, and model the majority of the proteins making up the ~23MDa assembly
Reposted by Jason Wilson
It's been a really fun project, led by @jasonwils.bsky.social in collaboration with @perbullough.bsky.social and Louis-Charles Fortier at the Université de Sherbrooke
March 26, 2025 at 2:21 PM
It's been a really fun project, led by @jasonwils.bsky.social in collaboration with @perbullough.bsky.social and Louis-Charles Fortier at the Université de Sherbrooke
I saw once posting the reply but couldn't find it to delete it 😅
February 4, 2025 at 5:18 PM
I saw once posting the reply but couldn't find it to delete it 😅
Hi there, great idea, could I get an add please
February 4, 2025 at 2:01 PM
Hi there, great idea, could I get an add please
Reposted by Jason Wilson
It’s often overlooked but TB remains the world’s worst single-agent infectious killer- drug resistance is growing and current drug regimens have awful side effects
December 5, 2024 at 10:16 PM
It’s often overlooked but TB remains the world’s worst single-agent infectious killer- drug resistance is growing and current drug regimens have awful side effects
Congrats Giusy! 🎉🎉
November 29, 2024 at 11:44 AM
Congrats Giusy! 🎉🎉
Hi there, Could I request an add please!
November 26, 2024 at 11:15 AM
Hi there, Could I request an add please!