What governs the relationship between the reaction rate and thermodynamic driving force? Despite decades of rate theory, no general physically grounded equation exists to relate rate and driving force...

Hybridization is a bonding model, universally used in organic chemistry, which allows consideration of two-electron localized bonds in organic molecules. Without hybridization, it is almost impossible...

The facile synthesis and spectroscopic identification of previously unreported hexanitrogen C2h-N6 is described, representing experimentally realized neutral molecular nitrogen allotropes beyond N2 th...

The Brønsted acid catalysis is widely regarded as one of the most effective methods for activating inert substrates and enabling unique reactivity. In this work, we introduce the first example of H-bond-assisted chalcogen exchange between arsine oxides and phosphine selenides under mild conditions, providing a powerful approach to the synthesis of arsine selenides. The reaction proceeds successfully in both protic and aprotic solvents and is accelerated by the presence of any nonaqueous acid. This newly discovered reaction is tested for various arsine oxides R3AsO (R = Ph, Et, nBu, iPr) and phosphine selenides R3PSe (R = Ph, Me, Et, tBu) and overall demonstrates high conversion, although the use of reagents with bulky substituents significantly hinders its efficiency. The reaction mechanism involves the formation of a four-membered cyclic transition state, which requires overcoming steric and electrostatic repulsion, as well as significant distortion of the reagents’ tetrahedral geometry. Hydrogen bonding with the As═O fragment helps to reduce electrostatic repulsion between the P═Se and As═O groups, making the formation of the cyclic intermediate more favorable.

France’s research minister said the scientist was traveling to Houston for a conference when his phone was searched

In this work, we propose a new Global Optimization Algorithm (GOAT) for molecules and clusters of atoms and show how it can find the global energy minima for both systems without resorting to molecul...

Heavier transition metal carbyne analogs hold significant potential for cooperative activation of small molecules. However, complexes containing more than one heavier tetrylidyne ligand RE (E = Si, Ge...

The Lewis acid-catalyzed coupling of alkenes and aldehydes presents a modern, versatile synthetic alternative to classical carbonyl addition chemistry, offering exceptional regio- and stereoselectivi...

Dispersion interactions serve as a driving force for ortho-lithiation: A significantly large and bulky substituent, rich in C−H bonds, attached to the pyridine nitrogen of 4-dimethylaminopyridine, st...