James Eles
@jamapjama.bsky.social
Data Science | Comp Bio | Neuroscience
Reposted by James Eles
The “prosecute the former regime at every level” candidate has my vote in 2028.
January 7, 2026 at 8:26 PM
The “prosecute the former regime at every level” candidate has my vote in 2028.
Reposted by James Eles
I'm in the March/April 2025 issue of the Director Journal by the Institute of Corporate Directors talking about how control of your data lies beyond your hands, even after death. You can check out the interview on pp. 48-49 📰
#datagov #bigdata #wethedata
#datagov #bigdata #wethedata
The age of AI (March/April 2025)
issuu.com
April 9, 2025 at 4:51 PM
I'm in the March/April 2025 issue of the Director Journal by the Institute of Corporate Directors talking about how control of your data lies beyond your hands, even after death. You can check out the interview on pp. 48-49 📰
#datagov #bigdata #wethedata
#datagov #bigdata #wethedata
Reposted by James Eles
Fascinating paper. The former philosophy major in me is always excited to see smart philosophy of science work break into the biomedical bubble. I'll definitely consider this in future systems modeling of TBI recovery: doi.org/10.3389/fneu...
March 29, 2025 at 9:44 AM
Fascinating paper. The former philosophy major in me is always excited to see smart philosophy of science work break into the biomedical bubble. I'll definitely consider this in future systems modeling of TBI recovery: doi.org/10.3389/fneu...
Reposted by James Eles
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 10:44 AM
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
Reposted by James Eles
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience
The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...
onlinelibrary.wiley.com
March 14, 2025 at 10:25 AM
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊
Reposted by James Eles
This is a bright spot to start the day (on the West Coast, that is). The paper on "possibility space" with @laurennross.bsky.social and Viktor Jirsa is now published!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
The Possibility Space Concept in Neuroscience: Possibilities, Constraints, and Explanations
Although the brain is often characterized as a complex system, theoretical and philosophical frameworks often struggle to capture this. For example, mainstream mechanistic accounts model neural syste...
onlinelibrary.wiley.com
March 13, 2025 at 2:07 PM
This is a bright spot to start the day (on the West Coast, that is). The paper on "possibility space" with @laurennross.bsky.social and Viktor Jirsa is now published!
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by James Eles
I was on the CBC Ideas 💡 podcast w/ the brilliant Nahlah Ayed, talking about data stickiness and how we need to become stakeholders in the data we co-create. Thank you to the fantastic production team at CBC!
Listen on CBC Listen App, or your fave app 👉 link.chtbl.com/IDEAS.
#ideas #wethedata #cbc
Listen on CBC Listen App, or your fave app 👉 link.chtbl.com/IDEAS.
#ideas #wethedata #cbc
Ideas
Society & Culture Podcast · 234 Episodes · Updated Daily
link.chtbl.com
March 12, 2025 at 4:19 PM
I was on the CBC Ideas 💡 podcast w/ the brilliant Nahlah Ayed, talking about data stickiness and how we need to become stakeholders in the data we co-create. Thank you to the fantastic production team at CBC!
Listen on CBC Listen App, or your fave app 👉 link.chtbl.com/IDEAS.
#ideas #wethedata #cbc
Listen on CBC Listen App, or your fave app 👉 link.chtbl.com/IDEAS.
#ideas #wethedata #cbc
Reposted by James Eles
Should you stick to your goal, try something else, or give up? Your median raphe nucleus in the brainstem knows and will decide for you 😉. First foray of my lab into foraging, behavioural strategies and exploration. Amazing work from the one and only Mehran Ahmadlou: www.nature.com/articles/s41...
A subcortical switchboard for perseverative, exploratory and disengaged states - Nature
Behavioural experiments in mice demonstrate that GABAergic (γ-aminobutyric acid-expressing), glutamatergic and serotonergic neurons in the median raphe nucleus have distinct and complementary function...
www.nature.com
March 5, 2025 at 8:27 PM
Should you stick to your goal, try something else, or give up? Your median raphe nucleus in the brainstem knows and will decide for you 😉. First foray of my lab into foraging, behavioural strategies and exploration. Amazing work from the one and only Mehran Ahmadlou: www.nature.com/articles/s41...
Reposted by James Eles
Groundbreaking work by Dr. Soohyun Lee from the National Institute of Mental Health at NIH
The brilliant young scientist faces termination.
Science like this leads to discoveries that can revolutionize how we understand the brain.
doi.org/10.1038/s415...
#neuroscience #neuroskyence
The brilliant young scientist faces termination.
Science like this leads to discoveries that can revolutionize how we understand the brain.
doi.org/10.1038/s415...
#neuroscience #neuroskyence
Brain-wide presynaptic networks of functionally distinct cortical neurons - Nature
Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...
doi.org
March 6, 2025 at 10:03 PM
Groundbreaking work by Dr. Soohyun Lee from the National Institute of Mental Health at NIH
The brilliant young scientist faces termination.
Science like this leads to discoveries that can revolutionize how we understand the brain.
doi.org/10.1038/s415...
#neuroscience #neuroskyence
The brilliant young scientist faces termination.
Science like this leads to discoveries that can revolutionize how we understand the brain.
doi.org/10.1038/s415...
#neuroscience #neuroskyence
Reposted by James Eles
🚨 new publication from our lab in @pnas.org !
"Expert navigators deploy rational complexity–based decision precaching for large-scale real-world planning"
Entropy of streets & successor representations explain planning speed
Colab wth Daniel McNamee at Champalimaud
www.pnas.org/doi/10.1073/...
"Expert navigators deploy rational complexity–based decision precaching for large-scale real-world planning"
Entropy of streets & successor representations explain planning speed
Colab wth Daniel McNamee at Champalimaud
www.pnas.org/doi/10.1073/...
January 27, 2025 at 3:39 PM
🚨 new publication from our lab in @pnas.org !
"Expert navigators deploy rational complexity–based decision precaching for large-scale real-world planning"
Entropy of streets & successor representations explain planning speed
Colab wth Daniel McNamee at Champalimaud
www.pnas.org/doi/10.1073/...
"Expert navigators deploy rational complexity–based decision precaching for large-scale real-world planning"
Entropy of streets & successor representations explain planning speed
Colab wth Daniel McNamee at Champalimaud
www.pnas.org/doi/10.1073/...
Reposted by James Eles
Very cool paper by Emily Oby and colleagues:
www.nature.com/articles/s41...
Interesting insights into the flexibility (or lack thereof) of neural dynamics for motor control
www.nature.com/articles/s41...
Interesting insights into the flexibility (or lack thereof) of neural dynamics for motor control
Dynamical constraints on neural population activity - Nature Neuroscience
Oby, Degenhart, Grigsby and colleagues used a brain–computer interface to challenge monkeys to override their natural time courses of neural activity. They found the time courses to be highly robust, ...
www.nature.com
January 18, 2025 at 1:02 PM
Very cool paper by Emily Oby and colleagues:
www.nature.com/articles/s41...
Interesting insights into the flexibility (or lack thereof) of neural dynamics for motor control
www.nature.com/articles/s41...
Interesting insights into the flexibility (or lack thereof) of neural dynamics for motor control
Reposted by James Eles
1/ Super-excited to share our new work “Episodic and associative memory from spatial scaffolds in the hippocampus”, that just appeared in Nature! www.nature.com/articles/s41... Key insights and ideas 👇#tweeprint
Episodic and associative memory from spatial scaffolds in the hippocampus - Nature
A neocortical–entorhinal–hippocampal network model based on grid cell states recapitulates experimental results and reconciles the spatial, associative and episodic memory roles of the hippocampus.
www.nature.com
January 17, 2025 at 12:08 AM
1/ Super-excited to share our new work “Episodic and associative memory from spatial scaffolds in the hippocampus”, that just appeared in Nature! www.nature.com/articles/s41... Key insights and ideas 👇#tweeprint
Reposted by James Eles
Have you wondered where scene perception and memory intersect in the brain?
Do you want to localize these areas?
In a preprint, @carolinerobertson.bsky.social, Deepa Prasad, Brenda Garcia, and I detail this topography and release these parcels and our localizer.
www.biorxiv.org/content/10.1...
Do you want to localize these areas?
In a preprint, @carolinerobertson.bsky.social, Deepa Prasad, Brenda Garcia, and I detail this topography and release these parcels and our localizer.
www.biorxiv.org/content/10.1...
January 7, 2025 at 3:15 PM
Have you wondered where scene perception and memory intersect in the brain?
Do you want to localize these areas?
In a preprint, @carolinerobertson.bsky.social, Deepa Prasad, Brenda Garcia, and I detail this topography and release these parcels and our localizer.
www.biorxiv.org/content/10.1...
Do you want to localize these areas?
In a preprint, @carolinerobertson.bsky.social, Deepa Prasad, Brenda Garcia, and I detail this topography and release these parcels and our localizer.
www.biorxiv.org/content/10.1...
Reposted by James Eles
SEEING THROUGH YOUR EYES 👁️:
Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus
nature.com/articles/s41... 🧵 1/12👇
Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus
nature.com/articles/s41... 🧵 1/12👇
Sleep microstructure organizes memory replay - Nature
The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.
nature.com
January 2, 2025 at 2:51 AM
SEEING THROUGH YOUR EYES 👁️:
Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus
nature.com/articles/s41... 🧵 1/12👇
Excited to share our new paper (which is out now @nature.com !!) with Wenbo Tang, Antonio Fernandez-Ruiz✉️, and Azahara Oliva✉️: we discovered a novel sleep microstructure that promotes memory replay! #Neuroscience #hippocampus
nature.com/articles/s41... 🧵 1/12👇
Reposted by James Eles
New year, new preprint!💫 I'm excited to share my first(!) postdoc paper working with Jim DiCarlo & @kohitij.bsky.social
#NeuroAI #CompNeuro
We revisited a long-standing question: How does category feedback (a.k.a. training) reconfigure IT responses? 🧠
Our long story short [1/7]:
#NeuroAI #CompNeuro
We revisited a long-standing question: How does category feedback (a.k.a. training) reconfigure IT responses? 🧠
Our long story short [1/7]:
(1/3) 🌟New preprint with @lynnkasorensen.bsky.social and Jim DiCarlo
When animals learn new object discrimination tasks, how much does their IT cortex change?
www.biorxiv.org/content/10.1...
When animals learn new object discrimination tasks, how much does their IT cortex change?
www.biorxiv.org/content/10.1...
The effects of object category training on the responses of macaque inferior temporal cortex are consistent with performance-optimizing updates within a visual hierarchy
How does the primate brain coordinate plasticity to support its remarkable ability to learn object categories? To address this question, we measured the consequences of category learning on the macaqu...
www.biorxiv.org
January 7, 2025 at 12:21 AM
New year, new preprint!💫 I'm excited to share my first(!) postdoc paper working with Jim DiCarlo & @kohitij.bsky.social
#NeuroAI #CompNeuro
We revisited a long-standing question: How does category feedback (a.k.a. training) reconfigure IT responses? 🧠
Our long story short [1/7]:
#NeuroAI #CompNeuro
We revisited a long-standing question: How does category feedback (a.k.a. training) reconfigure IT responses? 🧠
Our long story short [1/7]:
Reposted by James Eles
New clues about how the brain avoids ‘catastrophic forgetting’ — the distortion and overwriting of previously established memories when new ones are created. 🧪
Why don’t new memories overwrite old ones? Sleep science holds clues
Research in mice points towards a mechanism that avoids ‘catastrophic forgetting’.
www.nature.com
January 6, 2025 at 7:18 PM
New clues about how the brain avoids ‘catastrophic forgetting’ — the distortion and overwriting of previously established memories when new ones are created. 🧪
Reposted by James Eles
Dissecting origins of wiring specificity in dense cortical connectomes
Looks hot! Generative modeling for neural networks -- trying to get insight into the wiring rules of dense connectomes.
www.biorxiv.org/content/10.1...
Looks hot! Generative modeling for neural networks -- trying to get insight into the wiring rules of dense connectomes.
www.biorxiv.org/content/10.1...
December 30, 2024 at 3:02 PM
Dissecting origins of wiring specificity in dense cortical connectomes
Looks hot! Generative modeling for neural networks -- trying to get insight into the wiring rules of dense connectomes.
www.biorxiv.org/content/10.1...
Looks hot! Generative modeling for neural networks -- trying to get insight into the wiring rules of dense connectomes.
www.biorxiv.org/content/10.1...
Reposted by James Eles
Why do diverse ANNs resemble brain representations? Check out our new paper with Colton Casto, @nogazs.bsky.social , Colin Conwell, Mark Richardson, & @evfedorenko.bsky.social on “Universality of representation in biological and artificial neural networks.” 🧠🤖
tinyurl.com/yckndmjt
tinyurl.com/yckndmjt
Universality of representation in biological and artificial neural networks
Many artificial neural networks (ANNs) trained with ecologically plausible objectives on naturalistic data align with behavior and neural representations in biological systems. Here, we show that this...
tinyurl.com
December 27, 2024 at 8:14 PM
Why do diverse ANNs resemble brain representations? Check out our new paper with Colton Casto, @nogazs.bsky.social , Colin Conwell, Mark Richardson, & @evfedorenko.bsky.social on “Universality of representation in biological and artificial neural networks.” 🧠🤖
tinyurl.com/yckndmjt
tinyurl.com/yckndmjt
Reposted by James Eles
I wrote about a scientific paper called “The Unbearable Slowness of Being” which finds that the human brain’s throughput is just 10 bits per second. Gift link: www.nytimes.com/2024/12/26/s...
🧪
🧪
Human Thought Is Far Slower Than Your Internet Connection (Gift Article)
A new study is “a bit of a counterweight to the endless hyperbole about how incredibly complex and powerful the human brain is,” one researcher said.
www.nytimes.com
December 26, 2024 at 1:49 PM
I wrote about a scientific paper called “The Unbearable Slowness of Being” which finds that the human brain’s throughput is just 10 bits per second. Gift link: www.nytimes.com/2024/12/26/s...
🧪
🧪
Reposted by James Eles
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
December 26, 2024 at 5:31 PM
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Reposted by James Eles
Happy news! I was honoured to receive the Balsillie Prize for my new book We, the Data: Human Rights in the Digital Age! I am so thankful to the selection committee at Writer's Trust of Canada, and to the phenomenal Balsillie Prize finalists: Gregor Craigie, Christopher Pollon, and M.G. Vassanji 📚
Balsillie Prize for Public Policy
Thoughtful debate happens when all sides are well-read. Canadian books to inspire better policy.
www.writerstrust.com
November 27, 2024 at 9:02 PM
Happy news! I was honoured to receive the Balsillie Prize for my new book We, the Data: Human Rights in the Digital Age! I am so thankful to the selection committee at Writer's Trust of Canada, and to the phenomenal Balsillie Prize finalists: Gregor Craigie, Christopher Pollon, and M.G. Vassanji 📚