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JAMA Ophthalmology
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JAMA Ophthalmology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

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This case report describes a large choroidal excavation and outer retinal atrophy in an otherwise healthy man aged 29 years who presented with bilateral gradually worsening vision since childhood. ja.ma/49Y0DET
November 17, 2025 at 2:00 PM
This case report documents vision outcomes in a 15-year-old boy following orbital cellulitis and subperiosteal abscess. ja.ma/3K5QY4B
November 16, 2025 at 2:00 PM
Between 2014 and 2024, the number of ophthalmology practice locations increased, leading to improved access and reduced average driving distances from isolated optometry offices to ophthalmologists. ja.ma/47Zdxjk
November 15, 2025 at 2:00 PM
Manual marking-assisted capsulorhexis achieves similar accuracy and stability as digital guidance in cataract surgery.

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November 14, 2025 at 4:23 PM
Claude 3.5 Sonnet and GPT-4o outperform previous models and trainees in answering textual ophthalmology questions, but multimodal capabilities remain insufficient for clinical application. ja.ma/3LXwueQ
November 13, 2025 at 4:30 PM
Nearly 7% of US residents live over two hours from neuro-ophthalmology care, with the greatest gaps in rural and socioeconomically disadvantaged areas. ja.ma/3JMLr2O
November 11, 2025 at 2:00 PM
A previously healthy 31-year-old woman presents with acute unilateral anterior uveitis with hypopyon and an iris lesion and systemic symptoms, including headache, fatigue, and fever. What would you do next? ja.ma/3LuhvZW
November 10, 2025 at 2:00 PM
Apraclonidine eye drops may cause severe CNS and respiratory depression in infants and young children. ja.ma/3XeZn8O
November 9, 2025 at 2:00 PM
Five-year outcomes after pediatric traumatic cataract surgery showed low rates of glaucoma but frequent need for additional surgery and continued risk of vision loss.

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November 8, 2025 at 2:00 PM
Rigid gas-permeable contact lenses yielded superior visual outcomes compared to glasses in children following primary congenital #glaucoma surgery. ja.ma/43RkpOn
November 7, 2025 at 2:00 PM
Distinctive HR-OCT features in pseudoxanthoma elasticum highlight Bruch membrane calcification and provide a potential early marker for progression and treatment response.

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November 6, 2025 at 5:00 PM
Multifocal geographic atrophy is associated with faster progression and visual decline; risk factors for new lesion formation overlap only partially with those for initial GA occurrence.

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November 6, 2025 at 4:30 PM
This case report describes the grading and effects of myopic traction maculopathy in eyes with high myopia. ja.ma/4nrYzs1
November 4, 2025 at 12:00 PM
This case report discusses a diagnosis of posterior lenticonus with intralenticular cracks found during a school vision screening in a girl aged 8 years referred for decreased visual acuity in the left eye. ja.ma/4owwGzG
November 2, 2025 at 12:00 PM
This case report discusses a diagnosis of medication-associated maculopathy in a 44-year-old woman receiving exemestane treatment after breast cancer resection. ja.ma/4hv2oeA
November 1, 2025 at 12:00 PM
Case report: Oral tofacitinib achieved rapid and sustained remission in cases of refractory thyroid eye disease, targeting proinflammatory cytokine pathways implicated in orbital fibroblast activation. ja.ma/4oxIAJI
October 31, 2025 at 1:00 PM
Retinal capillary nonperfusion produces greater sensitivity deficits in people with #diabetic retinopathy, but one-third of perfused areas also show reduced function. ja.ma/4qthvJz
October 30, 2025 at 3:30 PM
RCT: Low-level red-light therapy for #myopia control slows axial elongation and refractive change, with some participants showing temporary retinal changes on OCT which resolved without affecting vision. ja.ma/3Wm4Dam
October 29, 2025 at 11:00 AM
Smooth pursuit eye movement velocity in Division I American football players was not affected by repetitive head impacts during a single season. ja.ma/3JewPsN
October 28, 2025 at 12:00 PM
While the incidence of ocular complications was higher in myopic children compared to nonmyopic ones, atropine use for #myopia control was not associated with these risks. ja.ma/4nnK2NH
October 27, 2025 at 11:00 AM
Advanced multimodal imaging indicates that vision loss in AZOOR initiates at the level of phototransduction within photoreceptor outer segments. ja.ma/4quIYdW
October 26, 2025 at 1:00 PM
Metformin use is not significantly associated with the development or progression of age-related macular degeneration (AMD), suggesting similar risks of AMD and its progression between those prescribed metformin and those not. ja.ma/3LcoqXj
October 26, 2025 at 12:00 PM
#GLP-1RA use was associated with reduced risk of developing nonexudative AMD but was not associated with progression to exudative AMD among individuals with nonexudative AMD.

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October 25, 2025 at 1:00 PM
Among people with type 2 #diabetes, risk of #retinopathy onset increased with higher HbA1C and frequent nonsevere #hypoglycemia. ja.ma/4nnHUpk
October 24, 2025 at 1:00 PM
Apixaban, paclitaxel, ibrutinib, and sildenafil use is associated with elevated rates of #maculopathy, with incidence estimates up to 15.7% and dose-dependent risk for some agents.

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October 23, 2025 at 3:30 PM