Super excited to share our work this morning in Cologne! Lots of great discussion on combining genomics and proteomics for discovery and prediction

And interestingly, ProRS values in the disease population are elevated even a decade before diagnosis! These scores then continue to rise up until diagnosis.

It'll be interesting to see how proteomics will continue to grow to help identify disease states and its application for precision medicine

While proteomic risk scores (ProRS) provide a dynamic look at a person's current health status, polygenic risk scores (PRS) can further stratify individuals by risk across a range of diseases

Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1