jakbosch.bsky.social
@jakbosch.bsky.social
My lab is recruiting post-docs! We study inter-organ communication using cutting-edge tools like proximity labeling (TurboID), in silico modeling (AlphaFold), and genome engineering (CRISPR). Come join us @UofUGenetics, Utah is beautiful! (View from our fly room 👇)
July 11, 2025 at 2:53 PM
Amazingly, we also found tissue-specific secreted proteins that accumulate in entirely different tissues! These may be remote-control factors that allow two organs to communicate (aka inter-organ communication).
5/8
July 11, 2025 at 2:51 PM
We discovered a gold mine of 535 circulating proteins! Highlights:
-Tissue-specific secreted proteins
-Unexpected sources like glia 🧠
-Shed ectodomains of transmembrane proteins
-Uncharacterized proteins
-Human-conserved proteins 🧬
4/8
July 11, 2025 at 2:51 PM
We built an atlas of secreted proteins in Drosophila blood from 10 different tissues using complementary ‘omics tools 🧬- transgenic TurboID proximity labeling, mass spectrometry, single nucleus RNA-seq, and CRISPR knock-in flies.
3/8
July 11, 2025 at 2:51 PM
Excited to be at fly meeting! #Dros25 🪰 Come by my poster #909F and see my talk #176. My lab is hiring! Including post-docs and lab techs. utah.peopleadmin.com/postings/179...
March 20, 2025 at 12:19 AM