Jacqueline Ehrlich
@jacquelineehrlich.bsky.social
Cornell PhD Candidate in the Kawate Lab | #membraneprotein #cryoEM & #celegans devotee | midwesterner 🌽 do-er 🏋️♀️be-er🧘♀️auntie 🤱
This is so kind! Thank you so much!! I’m glad you enjoyed it 😌
February 20, 2025 at 1:12 PM
This is so kind! Thank you so much!! I’m glad you enjoyed it 😌
February 14, 2025 at 4:32 PM
Thank you 🫶🫶
January 8, 2025 at 6:21 PM
Thank you 🫶🫶
This study puts forth a mechanism by which c-terminal cleavage liberates the CAD causing the repositioning of the N terminus to promote Panx1 channel opening.
January 3, 2025 at 2:23 AM
This study puts forth a mechanism by which c-terminal cleavage liberates the CAD causing the repositioning of the N terminus to promote Panx1 channel opening.
We analyzed the electrostatic free energy of the cytosolic NTD, finding a positively charged region inside the pore that could accumulate negatively charged anions like ATP. In the reoriented NTD conformation this negative region is diminished reducing accumulation of ions there.
January 3, 2025 at 2:23 AM
We analyzed the electrostatic free energy of the cytosolic NTD, finding a positively charged region inside the pore that could accumulate negatively charged anions like ATP. In the reoriented NTD conformation this negative region is diminished reducing accumulation of ions there.
Our structural studies revealed that when exposed, the cytoplasmic domain, dubbed the c-terminal activating domain (CAD) can compete with the N-terminus to occupy a cytosolic pocket, which forces the N-terminus to reorient into the pore.
January 3, 2025 at 2:23 AM
Our structural studies revealed that when exposed, the cytoplasmic domain, dubbed the c-terminal activating domain (CAD) can compete with the N-terminus to occupy a cytosolic pocket, which forces the N-terminus to reorient into the pore.
In this study, we identified a structure cytoplasmic domain immediately before a caspase cleave site, critical for Panx1 channel opening. This region must be exposed for ion permeation, but if this region is truncated, the channel cannot respond to any opening stimulus.
January 3, 2025 at 2:23 AM
In this study, we identified a structure cytoplasmic domain immediately before a caspase cleave site, critical for Panx1 channel opening. This region must be exposed for ion permeation, but if this region is truncated, the channel cannot respond to any opening stimulus.
In this study, we identified a structure cytoplasmic domain immediately before a caspase cleave site, critical for Panx1 channel opening. This region must be exposed for ion permeation, but if this region is truncated, the channel cannot respond to any opening stimulus.
January 3, 2025 at 2:16 AM
In this study, we identified a structure cytoplasmic domain immediately before a caspase cleave site, critical for Panx1 channel opening. This region must be exposed for ion permeation, but if this region is truncated, the channel cannot respond to any opening stimulus.