Iva Tolić
@ivatolic.bsky.social
Biophysics of mitosis / mitotic spindle / chromosome segregation and aneuploidy
Head of Laboratory of Cell Biophysics at @institutrb.bsky.social, previously at @mpi-cbg.de, LENS Florence, Niels Bohr Institute, @hsph.harvard.edu, Uni Zagreb.
tolic.irb.hr
Head of Laboratory of Cell Biophysics at @institutrb.bsky.social, previously at @mpi-cbg.de, LENS Florence, Niels Bohr Institute, @hsph.harvard.edu, Uni Zagreb.
tolic.irb.hr
In our second paper, we asked why only polar chromosomes depend on CENP-E for congression. We inhibited Plk4 to generate spindles where one pole had centrioles and the other did not. Strikingly, the acentriolar pole (on the right in the movie) rarely had polar chromosomes.
October 29, 2025 at 5:09 PM
In our second paper, we asked why only polar chromosomes depend on CENP-E for congression. We inhibited Plk4 to generate spindles where one pole had centrioles and the other did not. Strikingly, the acentriolar pole (on the right in the movie) rarely had polar chromosomes.
And now… part two of our twin papers on how chromosomes find their place before division! Led by @krunovuk.bsky.social at @institutrb.bsky.social, out in @natcomms.nature.com!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Missed the thread on the first paper? Catch up:
bsky.app/profile/ivat...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Missed the thread on the first paper? Catch up:
bsky.app/profile/ivat...
October 29, 2025 at 5:09 PM
And now… part two of our twin papers on how chromosomes find their place before division! Led by @krunovuk.bsky.social at @institutrb.bsky.social, out in @natcomms.nature.com!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Missed the thread on the first paper? Catch up:
bsky.app/profile/ivat...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Missed the thread on the first paper? Catch up:
bsky.app/profile/ivat...
Why can’t kinetochores start their movement without CENP-E? Is dynein holding them? No. This is due to Aurora kinases that oppose the formation of end-on attachments near the spindle poles. When Aurora B is inhibited in the absence of CENP-E, kinetochores start to move!
October 21, 2025 at 11:14 AM
Why can’t kinetochores start their movement without CENP-E? Is dynein holding them? No. This is due to Aurora kinases that oppose the formation of end-on attachments near the spindle poles. When Aurora B is inhibited in the absence of CENP-E, kinetochores start to move!
@krunovuk.bsky.social pushed the limits of long-term live-cell imaging by simultaneously imaging hundreds of cells for 24 h using lattice light-sheet microscopy. By adding chemical inhibitors, he tested a time-resolved hierarchy of molecular networks working during congression.
October 21, 2025 at 11:14 AM
@krunovuk.bsky.social pushed the limits of long-term live-cell imaging by simultaneously imaging hundreds of cells for 24 h using lattice light-sheet microscopy. By adding chemical inhibitors, he tested a time-resolved hierarchy of molecular networks working during congression.
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
October 21, 2025 at 11:14 AM
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...