Iván Núñez Martín
@ivannm97.bsky.social
PhD student at @AguileraLab, @CABIMER. Interested in DNA replication and genome instability
🧬 Checkpoint mutants undergo gradual degradation of nascent DNA at replication forks, which is prevented in the absence of Rad51, Mus81, Rad5 and Exo1
🧪 Heterologous expression of human PrimPol or overexpression of Mre11 can counteract the aberrant processing of replication forks
🧪 Heterologous expression of human PrimPol or overexpression of Mre11 can counteract the aberrant processing of replication forks
July 31, 2025 at 4:28 PM
🧬 Checkpoint mutants undergo gradual degradation of nascent DNA at replication forks, which is prevented in the absence of Rad51, Mus81, Rad5 and Exo1
🧪 Heterologous expression of human PrimPol or overexpression of Mre11 can counteract the aberrant processing of replication forks
🧪 Heterologous expression of human PrimPol or overexpression of Mre11 can counteract the aberrant processing of replication forks
📄 We identified Rad51, Mus81 and Rad5 to be involved in the irreversible replication fork arrest observed in yeast checkpoint mutants upon DNA damage, despite they are also required for normal fork progression or restart once the damage is removed
July 31, 2025 at 4:26 PM
📄 We identified Rad51, Mus81 and Rad5 to be involved in the irreversible replication fork arrest observed in yeast checkpoint mutants upon DNA damage, despite they are also required for normal fork progression or restart once the damage is removed