It was fun to share my passion for science at the #EuropeanResearchersNight in Groningen!
✨ Curious visitors
✅matched 🧫 plates with microbes to where they were collected
✅inspected flowers, berries, and lichens under the microscope🔬
✅ created their own “bacterial selfies”📸

Finally, how to make sense of (1) sub-ms agonist-induced dynamics seen in confocal, and (2) long-lived states (>100ms) in ABEL trap. How do they not average out?

In our updated model, sub-ms dynamics occurs within long-lived states:

Maybe, these long-lived states can interconvert on much longer timescales - in fact, Wei et al. showed long-lived states with dwell times of seconds before with TIRF:

doi.org/10.1016/j.st...

With ABEL-trap, we can see individual receptors for up to 2 seconds instead of milliseconds! in solution and without tethers

Consistent with our previous data, agonist NECA increases FRET in double-labeled A2A

This is the final piece of my PhD studies on #smFRET with A2A adenosine receptors #GPCR!

In our previous study, we observed sub-ms agonist-induced conformational dynamics of the A2A, but longer transitions (if any) were invisible in burst-wise data

doi.org/10.1038/s420...

It was a great Day 1 of the EMBL Symposium "New approaches and concepts in microbiology"! Stepping a little outside of my usual microscopy/biophysics bubble feels like the right kind of challenge - wish me more good ideas, inspiration, and coffee
#EESMicrobiology

⚛️Physics Olympiads hold a special place in my❤️

I cherish memories of my teachers and still enjoy the charm of the intellectual puzzles🥲

This year, I designed a few problems for the Dutch Physics Olympiads ⏳

Congratulations to the winners and good luck at #IPhO2025 🥳

🚨 #LLPS: New trick for an old membrane protein!

Homo- and hetero- biomolecular condensates of a native membrane protein in E. coli tagged with PopTag 🔬🦠

LacY-PopTag is functional and localizes at cell poles or mobile foci in a curvature-dependent manner

🔗 doi.org/10.21203/rs.3.rs-6571918/v1

Single-molecule microscopy is full of surprises:
see how anisotropy can be used to follow the conformational dynamics! 🤯 #24-state-model

"Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy" @jgp.org 🔥🔬

rupress.org/jgp/article/...

#review #microscopy #methods
"Advanced fluorescence lifetime-enhanced multiplexed nanoscopy of cells" by
@samratb.bsky.social and @romantsukanov.bsky.social

FLIM // super-resolution // SMLM // DNA-PAINT // multiplexed imaging // MIET

www.degruyter.com/document/doi...

Dual-color 💚❤️ sub-millisecond single-molecule tracking via MINFLUX 🍩🔬

reveals concurrent diffusion of nAchR receptors 🔐 and fluorescent cholesterol

#preprint:
researchsquare.com/article/rs-5...

Congrats to the authors! 👏👏