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Let’s give a warm welcome to Dr. Mengis! 🫴

💬 Say hi in the comments & connect on LinkedIn:
🔗 www.linkedin.com/in/tamara-me...

Are you also pushing the boundaries of #LumbarSpine research? Join ISSLS and be part of a global community shaping the future of spine science:
🔗 www.issls.org/membership

One of Dr. Mengis's recent impactful studies, published in JCI Insight, investigates immune responses linked to vertebral bone marrow changes, offering promising new perspectives for understanding and treating chronic low back pain.
📖 Read it here: pubmed.ncbi.nlm.nih.gov/38585427/

Dr. Mengis is a Postdoctoral Researcher at the Center of Experimental Rheumatology, University of Zurich, where she explores the intricate biology of spinal conditions with a focus on Modic changes. Her research highlights the key role of the intervertebral disc in the development of Modic changes.

The study showed:
➡️ Significant reduction in LBP (VAS scores) in the BM-MSC group
➡️ Improved quality of life and work ability
➡️ Strong safety profile, with no serious adverse events

In this randomized controlled trial, the team investigated the use of autologous bone marrow-derived mesenchymal stromal cells BM- #MSCs to treat patients with chronic low back pain #LBP linked to multilevel intervertebral disc degeneration (IDD).

issls-2025.p.asnevents.com.au/days/2025-05...

This research provides valuable insights into the role of mitochondrial oxidative stress in disc degeneration and highlights potential therapeutic strategies for low back pain interventions. Read the full study here: www.sciencedirect.com/science/arti...

Check out his latest study in #RedoxBiology! His work sheds light on how #OxidativeStress contributes to intervertebral disc degeneration and explores the therapeutic potential of targeting superoxide dismutase 2 to restore redox homeostasis in the disc.

One of his recent studies uses deep learning to analyze MRI data, revealing how lumbar muscle cross-sectional area and fat infiltration vary by sex, age, and clinical condition. Read their complete work here: link.springer.com/article/10.1...

Dr Jacopo Vitale's work bridges clinical practice and sports science, with a focus on enhancing spine health in individuals with back disorders. Dr Vitale investigates how spinal muscle morphology & function relate to patient-reported outcomes, aiming to optimize recovery & long-term spinal health.

In this study oral administration of senolytic drugs in a mouse model significantly reduced LBP, eliminated SnCs in intervertebral discs and the spinal cord, decreased inflammatory senescence-associated secretory phenotype factors, improved disc & bone health, & lowered pain marker expression