🚀 Introducing fully automated data processing for repeat-target #cryoEM.

Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention.

Preprint: www.biorxiv.org/content/10.1...

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

Been thinking about creating a collection of good protein structure figures, as inspiration for my own work.

#1 www.nature.com/articles/s41...

Overcoming air-water interface induced artifacts in Cryo-EM with protein nanocrates https://www.biorxiv.org/content/10.1101/2025.08.18.667046v1

>20 years ago, Zuker et al. discovered the mammalian sweet taste receptors

Now, an exciting collaboration between our labs reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online @cp-cell.bsky.social!
www.sciencedirect.com/science/article/pii/S0092867425004568

Molecule-MCP is a very cool tool connecting PyMOL and ChimeraX directly to Claude through the Model Context Protocol for prompt-assisted molecule modelling. Great stuff by Jinyuan Sun et al
github.com/ChatMol/mole...