@isaacmtzu.bsky.social
Computational biology of non-coding genome. Postdoctoral researcher | University of Toronto
Pinned
Comparative transcriptomics reveals an extracellular worm argonaute as an ancestral regulator of LTR retrotransposons.
Safeguarding the genome from non-self elements is essential for reproduction, development, and ageing. One of the major threats to genome integrity is Transposable Elements (TEs), which can be post–tr...
www.biorxiv.org
Thrilled to share our preprint on the ancestral function of the secreted Argonaute exWAGO 🧬🐙
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Improved spike-in normalization clarifies the relationship between active histone modifications and transcription https://www.biorxiv.org/content/10.1101/2025.11.25.690627v1
November 26, 2025 at 11:32 PM
Improved spike-in normalization clarifies the relationship between active histone modifications and transcription https://www.biorxiv.org/content/10.1101/2025.11.25.690627v1
Reposted
Programmed DNA elimination was present in the last common ancestor of Caenorhabditis nematodes https://www.biorxiv.org/content/10.1101/2025.10.23.681605v1
October 24, 2025 at 9:32 PM
Programmed DNA elimination was present in the last common ancestor of Caenorhabditis nematodes https://www.biorxiv.org/content/10.1101/2025.10.23.681605v1
Reposted
Argonautes and small RNAs associated with nematode programmed DNA elimination https://www.biorxiv.org/content/10.1101/2025.10.23.684123v1
October 24, 2025 at 2:19 AM
Argonautes and small RNAs associated with nematode programmed DNA elimination https://www.biorxiv.org/content/10.1101/2025.10.23.684123v1
Thrilled to share our preprint on the ancestral function of the secreted Argonaute exWAGO 🧬🐙
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Comparative transcriptomics reveals an extracellular worm argonaute as an ancestral regulator of LTR retrotransposons.
Safeguarding the genome from non-self elements is essential for reproduction, development, and ageing. One of the major threats to genome integrity is Transposable Elements (TEs), which can be post–tr...
www.biorxiv.org
September 25, 2025 at 1:46 PM
Thrilled to share our preprint on the ancestral function of the secreted Argonaute exWAGO 🧬🐙
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
The impact of rearing environment on C. elegans: Phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats https://www.biorxiv.org/content/10.1101/2025.09.07.674770v1
September 9, 2025 at 2:45 PM
The impact of rearing environment on C. elegans: Phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats https://www.biorxiv.org/content/10.1101/2025.09.07.674770v1
Reposted
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Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades | PNAS
Rates of phenotypic evolution vary across traits, and these evolutionary patterns
themselves evolve. Understanding how development contributes to s...
www.pnas.org
August 23, 2025 at 1:47 PM
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Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Reposted
Emergence and stabilisation of a neo-Y chromosome in nematode species with rare males https://www.biorxiv.org/content/10.1101/2025.07.25.666552v1
July 29, 2025 at 11:32 PM
Emergence and stabilisation of a neo-Y chromosome in nematode species with rare males https://www.biorxiv.org/content/10.1101/2025.07.25.666552v1
Reposted
🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: buff.ly/HQgprLp
July 24, 2025 at 8:01 PM
🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: buff.ly/HQgprLp
Reposted
#TREnD2025 virtual day is here!! First talk starting now! 🥳
We are excited to announce that registration for this year's Toronto RNA Enthusiasts' Day (TREnD) is now open!
July 10th, 1pm-4pm ET ONLINE for everyone
July 11th, 9am-7pm ET ONLINE across Canada and IN PERSON in Toronto
event.fourwaves.com/trend25/regi...
July 10th, 1pm-4pm ET ONLINE for everyone
July 11th, 9am-7pm ET ONLINE across Canada and IN PERSON in Toronto
event.fourwaves.com/trend25/regi...
July 10, 2025 at 5:12 PM
#TREnD2025 virtual day is here!! First talk starting now! 🥳
Reposted
Super excited to see our work shared with the scientific community! We know #Argonaute proteins can be extracellular, but can they be transferred to recipient cells and can they function? Happy reading!
A non-vesicular Argonaute protein is transmitted from nematode to mouse and is important for parasite survival https://www.biorxiv.org/content/10.1101/2025.04.01.646544v1
April 2, 2025 at 11:05 AM
Super excited to see our work shared with the scientific community! We know #Argonaute proteins can be extracellular, but can they be transferred to recipient cells and can they function? Happy reading!