@irobcross.bsky.social
Nick showing Ron Vale the eduWOSM.
June 22, 2025 at 8:02 AM
Nick showing Ron Vale the eduWOSM.
In BIORXIV/2025/651652, we use ATPγS to reveal a previously-occult kinesin state. In the Await-Isomerisation (AI) state, ATP is bound but NL docking and hydrolysis are inhibited. ATPγS overstabilises the AI state, producing a characteristic signature of load-independent 8 nm tethered backslips:
May 2, 2025 at 10:10 AM
In BIORXIV/2025/651652, we use ATPγS to reveal a previously-occult kinesin state. In the Await-Isomerisation (AI) state, ATP is bound but NL docking and hydrolysis are inhibited. ATPγS overstabilises the AI state, producing a characteristic signature of load-independent 8 nm tethered backslips:
Nick has been in Rennes, helping Romain Gibeaux install a WOSM-TIRF. Big happiness!
April 5, 2025 at 2:05 PM
Nick has been in Rennes, helping Romain Gibeaux install a WOSM-TIRF. Big happiness!
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.
February 12, 2025 at 4:22 PM
Yean Ming Chew and I wrote doi.org/10.1042/BST2... about MT lattice switching. We discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.