Irfan Kathiriya
@irfankathiriya.bsky.social
Pediatric Cardiac Anesthesiologist | Developmental Biologist
Reposted by Irfan Kathiriya
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Reposted by Irfan Kathiriya
truly amazing paper led by current postdoc Lisa Iwamoto-Stohl. "To our knowledge, this represents the first systematic evidence of proteomic asymmetry between sister blastomeres in the 2-cell mouse embryo." pubmed.ncbi.nlm.nih.gov/41344326/
Fertilization triggers early proteomic symmetry breaking in mammalian embryos - PubMed
While non-mammalian embryos often rely on spatial pre-patterning, mammalian development has long been thought to begin with equivalent blastomeres. However, emerging evidence challenges this. Here, using multiplexed and label-free single-cell proteomics, we identify over 300 asymmetrically abundant …
pubmed.ncbi.nlm.nih.gov
December 13, 2025 at 1:54 AM
truly amazing paper led by current postdoc Lisa Iwamoto-Stohl. "To our knowledge, this represents the first systematic evidence of proteomic asymmetry between sister blastomeres in the 2-cell mouse embryo." pubmed.ncbi.nlm.nih.gov/41344326/
Reposted by Irfan Kathiriya
Our 13th Annual Anesthesia Research Day featured a keynote address from Vivianne Tawfik, MD, PhD and presentations from our faculty and learners. There was also time to connect with colleagues while reviewing more than 45 poster presentations. More: anesthesia.ucsf.edu/ard25
#AnesthesiaResearch
#AnesthesiaResearch
December 16, 2025 at 10:18 PM
Our 13th Annual Anesthesia Research Day featured a keynote address from Vivianne Tawfik, MD, PhD and presentations from our faculty and learners. There was also time to connect with colleagues while reviewing more than 45 poster presentations. More: anesthesia.ucsf.edu/ard25
#AnesthesiaResearch
#AnesthesiaResearch
Reposted by Irfan Kathiriya
RESEARCH PAPER: MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis
By Muncie-Vasic et al. and Benoit Bruneau
➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract
Jon Muncie-Vasic Benoit Bruneau
#transcriptionfactor #embryodevelopment #cardiactract
By Muncie-Vasic et al. and Benoit Bruneau
➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract
Jon Muncie-Vasic Benoit Bruneau
#transcriptionfactor #embryodevelopment #cardiactract
December 8, 2025 at 7:00 PM
RESEARCH PAPER: MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis
By Muncie-Vasic et al. and Benoit Bruneau
➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract
Jon Muncie-Vasic Benoit Bruneau
#transcriptionfactor #embryodevelopment #cardiactract
By Muncie-Vasic et al. and Benoit Bruneau
➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract
Jon Muncie-Vasic Benoit Bruneau
#transcriptionfactor #embryodevelopment #cardiactract
Reposted by Irfan Kathiriya
Accepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...
Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease
While atrial septal defects (ASDs) and atrial fibrillation (AF) present differently, there is evidence that they share some genetic basis. Here, we used directed differentiation of human induced pluri...
journals.biologists.com
December 19, 2025 at 6:32 PM
Accepted ms on modeling human atrial disease posted @dev-journal.bsky.social just now. Congratulations to @irfankathiriya.bsky.social @jsauce7.bsky.social and team! @gladstoneinst.bsky.social @ucsfanesthesia.bsky.social journals.biologists.com/dev/article-...
Reposted by Irfan Kathiriya
📽 G&D Tapes 📽
G&D Author, Jon Muncie-Vasic tells us about their new study in #genesdev that defines the role of MEF2C in cardiac tract development.
Read the full story here:
➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract
Jon Muncie-Vasic Benoit Bruneau Gladstone Institutes
G&D Author, Jon Muncie-Vasic tells us about their new study in #genesdev that defines the role of MEF2C in cardiac tract development.
Read the full story here:
➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract
Jon Muncie-Vasic Benoit Bruneau Gladstone Institutes
December 19, 2025 at 6:02 PM
📽 G&D Tapes 📽
G&D Author, Jon Muncie-Vasic tells us about their new study in #genesdev that defines the role of MEF2C in cardiac tract development.
Read the full story here:
➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract
Jon Muncie-Vasic Benoit Bruneau Gladstone Institutes
G&D Author, Jon Muncie-Vasic tells us about their new study in #genesdev that defines the role of MEF2C in cardiac tract development.
Read the full story here:
➡️ https://genesdev.cshlp.org/content/39/23-24/1451.abstract
Jon Muncie-Vasic Benoit Bruneau Gladstone Institutes