Butt Lab - Oxford
@interneuron.bsky.social
How the mammalian brain comes online with a focus on local GABAergic interneurons | electrophysiology & imaging | in vitro & in vivo approaches 🧠🧪
Quite the faff, 2 amazing PDRAs and a crazy good PhD student. Still, made writing the limitations section quite easy 😉. I hope all is well with you Mick!
September 29, 2025 at 8:04 AM
Quite the faff, 2 amazing PDRAs and a crazy good PhD student. Still, made writing the limitations section quite easy 😉. I hope all is well with you Mick!
Great credit must go to the team Filippo, Liad, and the rest of the gang for persevering and demonstrating that (mainly SST) interneurons contribute to the formative activity that sculpts and creates the circuits that underpin our conscious thoughts. Thanks also to our funders @ukri.org!
September 18, 2025 at 4:16 PM
Great credit must go to the team Filippo, Liad, and the rest of the gang for persevering and demonstrating that (mainly SST) interneurons contribute to the formative activity that sculpts and creates the circuits that underpin our conscious thoughts. Thanks also to our funders @ukri.org!
Many thanks to all the team and our collaborators but especially Gabriel Ocana-Santero for his amazing in vivo imaging and Hannah Warming for her patching skills. The work was funded by grants from @ukri.org and @erc.europa.eu
June 6, 2025 at 9:34 AM
Many thanks to all the team and our collaborators but especially Gabriel Ocana-Santero for his amazing in vivo imaging and Hannah Warming for her patching skills. The work was funded by grants from @ukri.org and @erc.europa.eu
Increasing 5-HT during this time through genetic, pharmacological (SSRIs) or adverse stimuli results in an altered trajectory for the development of GABAergic interneurons, impacting early activity and – in the case of SSRIs – that present through to adulthood.
The article is here: rdcu.be/epHXV
The article is here: rdcu.be/epHXV
Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding
Nature Communications - Ocana-Santero and colleagues show that serotonin is a key regulator of sensory programming. Early life SSRI exposure alters the developmental trajectory of interneurons to...
rdcu.be
June 6, 2025 at 9:34 AM
Increasing 5-HT during this time through genetic, pharmacological (SSRIs) or adverse stimuli results in an altered trajectory for the development of GABAergic interneurons, impacting early activity and – in the case of SSRIs – that present through to adulthood.
The article is here: rdcu.be/epHXV
The article is here: rdcu.be/epHXV
For sure! Although my feeling is that Mother Nature always finds a way to (a proximity of) normal.
January 6, 2025 at 7:19 PM
For sure! Although my feeling is that Mother Nature always finds a way to (a proximity of) normal.
Thank you so much Zoltan @zoltan-molnar.bsky.social and Gilad for being such wonderful examiners! The perfect academic end to the calendar year
December 21, 2024 at 7:37 AM
Thank you so much Zoltan @zoltan-molnar.bsky.social and Gilad for being such wonderful examiners! The perfect academic end to the calendar year
I’m might be biased but we’re getting there with tracking circuits over development and into adulthood (in mice). Some interesting commonalities/pathways emerging
biorxiv.org/cgi/content/...
biorxiv.org/cgi/content/...
Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding
Serotonin plays a prominent role in neurodevelopment, regulating processes from cell division to synaptic connectivity. Clinical studies suggest that alterations in serotonin signalling such as geneti...
biorxiv.org
December 15, 2024 at 5:53 PM
I’m might be biased but we’re getting there with tracking circuits over development and into adulthood (in mice). Some interesting commonalities/pathways emerging
biorxiv.org/cgi/content/...
biorxiv.org/cgi/content/...