Ines Sturmlechner
@inessturmlechner.bsky.social
Post-doc, K99 awardee, studying the aging immune system at Mayo Clinic, Leading Edge fellow, former AFAR/Glenn Foundation fellow | PhD, cellular senescence at University Groningen and Mayo Clinic | MSc, tRNA maturation at IMBA Vienna
Congrats! Very interesting topic!
August 15, 2025 at 4:05 AM
Congrats! Very interesting topic!
Reposted by Ines Sturmlechner
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Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities
The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.
www.nature.com
July 14, 2025 at 11:25 PM
This story was made possible thanks to NIH staff who reached out. I'm always looking for more sources, message me on Signal (mkozlov.01).
If you hit a paywall, making a free account will open the full story.
If you hit a paywall, making a free account will open the full story.
Huge thank you 🙏 to my awesome co-first author Abhinav Jain @abhinav1993.bsky.social, all co-authors, the Robert & Arlene Kogod Center on Aging, AFAR @afar.org, and the San Diego NSC @nathanshockcenters.org for all their support! 🙏
July 14, 2025 at 12:16 PM
Huge thank you 🙏 to my awesome co-first author Abhinav Jain @abhinav1993.bsky.social, all co-authors, the Robert & Arlene Kogod Center on Aging, AFAR @afar.org, and the San Diego NSC @nathanshockcenters.org for all their support! 🙏
➡️ intriguing contribution of TCR avidity in this process – low TCR avidity may select for cells prone to acquire innate/NK features, while high TCR avidity associates with stem-like features and may be lost with aging
July 14, 2025 at 12:16 PM
➡️ intriguing contribution of TCR avidity in this process – low TCR avidity may select for cells prone to acquire innate/NK features, while high TCR avidity associates with stem-like features and may be lost with aging
➡️ many aging changes are happening and common to many, but not all, EBV-specific T cell populations is a loss of stem-like traits and a gain of lymphocyte innateness = CD8+ T cells become more like NK cells as they age
➡️ no evidence of age-related exhaustion or cellular senescence
➡️ no evidence of age-related exhaustion or cellular senescence
July 14, 2025 at 12:16 PM
➡️ many aging changes are happening and common to many, but not all, EBV-specific T cell populations is a loss of stem-like traits and a gain of lymphocyte innateness = CD8+ T cells become more like NK cells as they age
➡️ no evidence of age-related exhaustion or cellular senescence
➡️ no evidence of age-related exhaustion or cellular senescence
➡️ human memory CD8+ T cells specific to different Epstein-Barr virus proteins acquire diverse phenotypes already in young adults
➡️ depending on the antigen specificity, these memory CD8+ T cells follow divergent phenotypic and transcriptional aging trajectories, in older adults
➡️ depending on the antigen specificity, these memory CD8+ T cells follow divergent phenotypic and transcriptional aging trajectories, in older adults
July 14, 2025 at 12:16 PM
➡️ human memory CD8+ T cells specific to different Epstein-Barr virus proteins acquire diverse phenotypes already in young adults
➡️ depending on the antigen specificity, these memory CD8+ T cells follow divergent phenotypic and transcriptional aging trajectories, in older adults
➡️ depending on the antigen specificity, these memory CD8+ T cells follow divergent phenotypic and transcriptional aging trajectories, in older adults
Thank you, Matt!!
May 27, 2025 at 11:15 PM
Thank you, Matt!!
This sounds very cool and useful!!
Congrats!
Congrats!
April 25, 2025 at 6:57 PM
This sounds very cool and useful!!
Congrats!
Congrats!