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@incicnrs
@incicnrs.bsky.social
The INCI explores the nervous system and its pathologies | L'INCI explore le système nerveux et ses pathologies | @CNRS | @unistra
Reposted by @incicnrs
Using a prospectively registered methodology, we included and reviewed 99 articles that manipulated the enzymes or characterized DNA methylation at candidate genes, or more recently genome-wide, including in the context of in utero or developmental exposure to drugs.
November 15, 2025 at 10:37 AM
Reposted by @incicnrs
November 5, 2025 at 3:57 PM
Reposted by @incicnrs
Overall, we uncover a profound epigenetic sex divergence that mediates convergent biological dysregulation, and highlight opportunities for developing improved therapeutic strategies tailored to sex-specific mechanisms.
www.biorxiv.org/content/10.1...
Sex-divergent brain epigenetic reprogramming by chronic opioids
Opioid use disorder (OUD) is a chronic condition that exhibits sex differences in prevalence, symptoms and treatment. Yet, the epigenetic mechanisms underlying these differences remain largely unknown...
www.biorxiv.org
October 28, 2025 at 5:48 PM
November 26, 2024 at 10:16 AM
November 26, 2024 at 10:15 AM