@incicnrs
@incicnrs.bsky.social
The INCI explores the nervous system and its pathologies | L'INCI explore le système nerveux et ses pathologies | @CNRS | @unistra
Reposted by @incicnrs
Using a prospectively registered methodology, we included and reviewed 99 articles that manipulated the enzymes or characterized DNA methylation at candidate genes, or more recently genome-wide, including in the context of in utero or developmental exposure to drugs.
November 15, 2025 at 10:37 AM
Using a prospectively registered methodology, we included and reviewed 99 articles that manipulated the enzymes or characterized DNA methylation at candidate genes, or more recently genome-wide, including in the context of in utero or developmental exposure to drugs.
Reposted by @incicnrs
If interested in epigenomics & substance use disorders, take a look at our systematic review. We summarize current knowledge on DNA methylation & related enzymes across rodent models & drugs of abuse. Written w/ PhD student Margot Diringer & post-doc Mathieu Bruggeman
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The DNA methylation enzymatic machinery in substance use disorders: a systematic review
Substance use disorders (SUD) are chronic affections defined by similar symptoms across a variety of psychoactive drugs, including alcohol, cocaine, opioids, or methamphetamine. Epigenetic mechanisms ...
www.biorxiv.org
November 15, 2025 at 10:37 AM
If interested in epigenomics & substance use disorders, take a look at our systematic review. We summarize current knowledge on DNA methylation & related enzymes across rodent models & drugs of abuse. Written w/ PhD student Margot Diringer & post-doc Mathieu Bruggeman
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by @incicnrs
And don't hesitate to reach out if interested, in particular about mental health & neuroepigenetics. @incicnrs.bsky.social @agencerecherche.bsky.social
@cnrs.fr @cnrsbiologie.bsky.social @inserm.fr
@frm-officiel.bsky.social @fondationfyssen.bsky.social
@procrystal.bsky.social
@cnrs.fr @cnrsbiologie.bsky.social @inserm.fr
@frm-officiel.bsky.social @fondationfyssen.bsky.social
@procrystal.bsky.social
November 5, 2025 at 3:57 PM
And don't hesitate to reach out if interested, in particular about mental health & neuroepigenetics. @incicnrs.bsky.social @agencerecherche.bsky.social
@cnrs.fr @cnrsbiologie.bsky.social @inserm.fr
@frm-officiel.bsky.social @fondationfyssen.bsky.social
@procrystal.bsky.social
@cnrs.fr @cnrsbiologie.bsky.social @inserm.fr
@frm-officiel.bsky.social @fondationfyssen.bsky.social
@procrystal.bsky.social
Reposted by @incicnrs
The Strasbourg (France) neuroscience community (NeuroStra) will offer 3 positions over the next 3 years for junior group leaders. Applicants should develop projects along 3 themes:
--> Mental health
--> Neuroepigenetics
--> Nociception and Pain
Spread the word!
neurostra.unistra.fr/actualites/a...
--> Mental health
--> Neuroepigenetics
--> Nociception and Pain
Spread the word!
neurostra.unistra.fr/actualites/a...
Junior group leader position in Strasbourg
NeuroStra aims to recruit outstanding junior scientists to develop projects aligned with the following themes: Mental health | Neuroepigenetics | Nociception and Pain
neurostra.unistra.fr
November 5, 2025 at 3:57 PM
The Strasbourg (France) neuroscience community (NeuroStra) will offer 3 positions over the next 3 years for junior group leaders. Applicants should develop projects along 3 themes:
--> Mental health
--> Neuroepigenetics
--> Nociception and Pain
Spread the word!
neurostra.unistra.fr/actualites/a...
--> Mental health
--> Neuroepigenetics
--> Nociception and Pain
Spread the word!
neurostra.unistra.fr/actualites/a...
Reposted by @incicnrs
Overall, we uncover a profound epigenetic sex divergence that mediates convergent biological dysregulation, and highlight opportunities for developing improved therapeutic strategies tailored to sex-specific mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Sex-divergent brain epigenetic reprogramming by chronic opioids
Opioid use disorder (OUD) is a chronic condition that exhibits sex differences in prevalence, symptoms and treatment. Yet, the epigenetic mechanisms underlying these differences remain largely unknown...
www.biorxiv.org
October 28, 2025 at 5:48 PM
Overall, we uncover a profound epigenetic sex divergence that mediates convergent biological dysregulation, and highlight opportunities for developing improved therapeutic strategies tailored to sex-specific mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by @incicnrs
Happy to share our new preprint on opioid addiction! We profiled the multiomic consequences of chronic opioid exposure in male and female mouse brains, covering DNA methylation (using EMseq), 5 histone marks (Cut&Tag) & their transcriptional effects at bulk and cell-type-specific levels (vTRAP).
October 28, 2025 at 5:48 PM
Happy to share our new preprint on opioid addiction! We profiled the multiomic consequences of chronic opioid exposure in male and female mouse brains, covering DNA methylation (using EMseq), 5 histone marks (Cut&Tag) & their transcriptional effects at bulk and cell-type-specific levels (vTRAP).
Reposted by @incicnrs
Nous appelons à la pérennisation des Haltes Soins Addictions (#HSA), avec @alexandracordebard.bsky.social @michelerubirola.bsky.social et Alexandre Feltz.
À Paris et à Strasbourg, ces dispositifs essentiels de santé publique ont montré leur efficacité, confirmée par l'Inserm et l'IGAS.
À Paris et à Strasbourg, ces dispositifs essentiels de santé publique ont montré leur efficacité, confirmée par l'Inserm et l'IGAS.
Drogues : des élus appellent le gouvernement à pérenniser les « salles de consommation à moindre risque » par une loi - Public Sénat
Lors d’une conférence de presse au Sénat, plusieurs élus locaux et nationaux ont appelé l’Etat à se saisir de la question des Haltes Soins Addictions (HSA), ces salles de consommation et de soins pour...
www.publicsenat.fr
May 13, 2025 at 2:39 PM
Nous appelons à la pérennisation des Haltes Soins Addictions (#HSA), avec @alexandracordebard.bsky.social @michelerubirola.bsky.social et Alexandre Feltz.
À Paris et à Strasbourg, ces dispositifs essentiels de santé publique ont montré leur efficacité, confirmée par l'Inserm et l'IGAS.
À Paris et à Strasbourg, ces dispositifs essentiels de santé publique ont montré leur efficacité, confirmée par l'Inserm et l'IGAS.
Reposted by @incicnrs
Une belle conférence de Raoul Belzeaux pour en savoir plus sur les biomarqueurs en psychiatrie :
www.youtube.com/live/U23xWQv...
www.youtube.com/live/U23xWQv...
Biomarqueurs en psychiatrie : quelle perspective ? Quels défis ?
YouTube video by Bibliothèques de Marseille
www.youtube.com
April 4, 2025 at 10:48 AM
Une belle conférence de Raoul Belzeaux pour en savoir plus sur les biomarqueurs en psychiatrie :
www.youtube.com/live/U23xWQv...
www.youtube.com/live/U23xWQv...
Reposted by @incicnrs
Happy to share our latest work. We analyzed 3 omic layers, DNA methylation, micro-RNAs & the transcriptome, in patients with major depressive disorder & controls. Results showed that the performance of MDD prediction increased with the number of layers considered. www.thelancet.com/journals/ebi...
Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study
Informational gain from multiomic integration had already been documented in other
medical fields. Our results pave the way toward similar advances in molecular psychiatry,
and have practical implicat...
www.thelancet.com
February 5, 2025 at 8:03 PM
Happy to share our latest work. We analyzed 3 omic layers, DNA methylation, micro-RNAs & the transcriptome, in patients with major depressive disorder & controls. Results showed that the performance of MDD prediction increased with the number of layers considered. www.thelancet.com/journals/ebi...
Reposted by @incicnrs
A team effort with many friends & colleagues @cnrs.bsky.social @incicnrs.bsky.social @cnrsbiologie.bsky.social @ap-hp.bsky.social @unistra.fr @univ-amu.fr @upcite.bsky.social @douglasresearch.bsky.social @univ-spn.bsky.social
February 5, 2025 at 8:15 PM
A team effort with many friends & colleagues @cnrs.bsky.social @incicnrs.bsky.social @cnrsbiologie.bsky.social @ap-hp.bsky.social @unistra.fr @univ-amu.fr @upcite.bsky.social @douglasresearch.bsky.social @univ-spn.bsky.social
New work from Tsvetan Serchov & colleagues:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice - Nature Communications
Depression is associated with dysregulated circadian rhythms. Here, the authors show a critical role for mPFC molecular clock in regulating depression-like behavior and therapeutic potential of clock ...
www.nature.com
November 26, 2024 at 10:15 AM
New work from Tsvetan Serchov & colleagues:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New work from Hervé Cadiou & colleagues:
www.frontiersin.org/journals/mol...
www.frontiersin.org/journals/mol...
Frontiers | Behavioral and pharmacological characterization of planarian nociception
IntroductionPain mostly arises because specialized cells called nociceptors detect harmful or potentially harmful stimuli. In lower animals with less convolu...
www.frontiersin.org
November 26, 2024 at 10:14 AM
New work from Hervé Cadiou & colleagues:
www.frontiersin.org/journals/mol...
www.frontiersin.org/journals/mol...