@ihcurrent.bsky.social
Now published in PNAS! Congrats to my amazing colleagues Julia and Blaise & postdoctoral mentor Rick! www.pnas.org/doi/10.1073/...
Here we've dissociated enzymatic vs structural roles of SYNGAP1 in neuronal physiology and seizure susceptibility. This will inform treatment development for this NDD!
Here we've dissociated enzymatic vs structural roles of SYNGAP1 in neuronal physiology and seizure susceptibility. This will inform treatment development for this NDD!
Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility | PNAS
SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing
intellectual disability and epilepsy in humans. Recent stu...
www.pnas.org
April 28, 2025 at 10:18 PM
Now published in PNAS! Congrats to my amazing colleagues Julia and Blaise & postdoctoral mentor Rick! www.pnas.org/doi/10.1073/...
Here we've dissociated enzymatic vs structural roles of SYNGAP1 in neuronal physiology and seizure susceptibility. This will inform treatment development for this NDD!
Here we've dissociated enzymatic vs structural roles of SYNGAP1 in neuronal physiology and seizure susceptibility. This will inform treatment development for this NDD!
Congrats to my dear colleagues Julia Brill, Blaise Clarke, and @rhuganir.bsky.social! And thanks to the many people who helped with this research. Lastly, thanks to
@curesyngap1.bsky.social and all Syngapian families who inspired our science.
@curesyngap1.bsky.social and all Syngapian families who inspired our science.
January 17, 2025 at 9:38 PM
Congrats to my dear colleagues Julia Brill, Blaise Clarke, and @rhuganir.bsky.social! And thanks to the many people who helped with this research. Lastly, thanks to
@curesyngap1.bsky.social and all Syngapian families who inspired our science.
@curesyngap1.bsky.social and all Syngapian families who inspired our science.
Seizures and epilepsy are serious symptoms of #SYNGAP1 syndrome, which arises from LoF mutations in the gene. Our finding has important implications in the treatment of this condition because it shows that the structural role of SYNGAP1 will need to be rescued by therapies.
January 17, 2025 at 9:38 PM
Seizures and epilepsy are serious symptoms of #SYNGAP1 syndrome, which arises from LoF mutations in the gene. Our finding has important implications in the treatment of this condition because it shows that the structural role of SYNGAP1 will need to be rescued by therapies.
This unexpected structural role was discovered when
#YoichiAraki made GAP-deficient* mutant Syngap1 mice & explored LLPS with other molecules. GAP-regulation of intrinsic excitability builds on earlier findings by #GavinRumbaugh & establishes SYNGAP1 as a bifunctional molecule.
#YoichiAraki made GAP-deficient* mutant Syngap1 mice & explored LLPS with other molecules. GAP-regulation of intrinsic excitability builds on earlier findings by #GavinRumbaugh & establishes SYNGAP1 as a bifunctional molecule.
January 17, 2025 at 9:38 PM
This unexpected structural role was discovered when
#YoichiAraki made GAP-deficient* mutant Syngap1 mice & explored LLPS with other molecules. GAP-regulation of intrinsic excitability builds on earlier findings by #GavinRumbaugh & establishes SYNGAP1 as a bifunctional molecule.
#YoichiAraki made GAP-deficient* mutant Syngap1 mice & explored LLPS with other molecules. GAP-regulation of intrinsic excitability builds on earlier findings by #GavinRumbaugh & establishes SYNGAP1 as a bifunctional molecule.