Excited to share our new preprint on #SYNGAP1 that shows how its enzymatic and structural role can be dissociated! The GAP activity is essential in increasing intrinsic excitability but does not contribute to the seizure protection SynGAP is important for: biorxiv.org/content/10.1...

Preprint of our new manuscript describing the differential enzymatic and structural roles of SYNGAP1. These findings highlight the complex interplay between SYNGAP1 structural and catalytic functions in neuronal physiology and disease.
www.biorxiv.org/content/10.1...