SmithLabIRIC
@idomyownexpts.bsky.social
Views from the own. 🇨🇦
IRIC/UdeM
IRIC/UdeM
Nice collaboration with the Abankwa lab (University of Luxembourg) on development of peptide-based PDE6D inhibitors, and congrats to our shared PhD candidate Atanasio Gómez-Mulas!
doi.org/10.1002/cbic...
doi.org/10.1002/cbic...
Development of a Genetically Encoded and Potent PDE6D Inhibitor
PDE6D is a trafficking chaperone of prenylated proteins. Current small molecule PDE6D inhibitors target its hydrophobic pocket, rendering them typically poorly water soluble. Herein, PDE6D binders ar...
doi.org
December 9, 2025 at 4:45 PM
Nice collaboration with the Abankwa lab (University of Luxembourg) on development of peptide-based PDE6D inhibitors, and congrats to our shared PhD candidate Atanasio Gómez-Mulas!
doi.org/10.1002/cbic...
doi.org/10.1002/cbic...
I want to highlight this review from Laura Quirion (@jf-cotelab.bsky.social) and Regina Strakhova (my lab) on ARF GTPases. Great read on the atypical nature of ARF/ARL small GTPase signalling, and they make it clear there is still much we don't know!
doi.org/10.3389/fmol...
doi.org/10.3389/fmol...
Frontiers | Unfolding ARF and ARL GTPases: from biophysics to systems-level insights
Advanced technologies to study protein biophysics, mRNA expression and protein-protein interactions at high throughput in physiological or pathological conte...
doi.org
December 9, 2025 at 4:35 PM
I want to highlight this review from Laura Quirion (@jf-cotelab.bsky.social) and Regina Strakhova (my lab) on ARF GTPases. Great read on the atypical nature of ARF/ARL small GTPase signalling, and they make it clear there is still much we don't know!
doi.org/10.3389/fmol...
doi.org/10.3389/fmol...
love this work - super cool and nice thread explaining potential evolutionary implications
Latest from ours: www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
October 10, 2025 at 11:59 AM
love this work - super cool and nice thread explaining potential evolutionary implications
PhD Position – Cancer Signalling and Structural Biology
Institute for Research in Immunology and Cancer (IRIC), Université de Montréal
www.linkedin.com/posts/matthe...
Institute for Research in Immunology and Cancer (IRIC), Université de Montréal
www.linkedin.com/posts/matthe...
Smith Lab, IRIC | Matthew Smith
PhD Position – Cancer Signalling and Structural Biology
Institute for Research in Immunology and Cancer (IRIC), Université de Montréal
My lab is seeking a highly motivated PhD student to join our mult...
www.linkedin.com
October 6, 2025 at 8:19 PM
PhD Position – Cancer Signalling and Structural Biology
Institute for Research in Immunology and Cancer (IRIC), Université de Montréal
www.linkedin.com/posts/matthe...
Institute for Research in Immunology and Cancer (IRIC), Université de Montréal
www.linkedin.com/posts/matthe...
Reposted by SmithLabIRIC
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
September 29, 2025 at 2:58 PM
Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
www.biozentrum.unibas.ch/open-positio...
#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging
Reposted by SmithLabIRIC
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Reposted by SmithLabIRIC
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
August 28, 2025 at 8:47 PM
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
Reposted by SmithLabIRIC
Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share
docs.google.com/document/d/1...
docs.google.com/document/d/1...
National Letter
Open Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne...
docs.google.com
April 12, 2025 at 2:06 PM
Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share
docs.google.com/document/d/1...
docs.google.com/document/d/1...
Cool review on a relatively understudied posttranslational modification: oxidation. Our colleagues in the Labbé lab at IRIC have been working to figure out the function of OSGIN proteins in cytokinesis - and its nicely summarized here!
dx.doi.org/10.1080/1538...
dx.doi.org/10.1080/1538...
Leaving the mark: FMOs as an emerging class of cytokinetic regulators
Posttranslational modification of proteins plays a fundamental role in cell biology. It provides cells a means to regulate the signaling, enzymatic or structural properties of proteins without cont...
dx.doi.org
April 9, 2025 at 2:44 PM
Cool review on a relatively understudied posttranslational modification: oxidation. Our colleagues in the Labbé lab at IRIC have been working to figure out the function of OSGIN proteins in cytokinesis - and its nicely summarized here!
dx.doi.org/10.1080/1538...
dx.doi.org/10.1080/1538...