Dark Matter Project
@id-darkmatter-ncd.bsky.social
The ID-DarkMatter-NCD Project is a Horizon Europe funded project to study immune related non-communicable disease (NCDs), unraveling the Dark Matter of infectious diseases, environmental and genetic factors tipping the balance towards NCDs.
Thomas Vogl, group leader at MedUni Vienna and coordinator of the DarkMatter project, has been selected for the EMBO Young Investigator Programme. His team explores how the gut microbiome and immune system shape cancer development and therapy response-an important recognition of his innovative work
December 4, 2025 at 7:40 AM
Thomas Vogl, group leader at MedUni Vienna and coordinator of the DarkMatter project, has been selected for the EMBO Young Investigator Programme. His team explores how the gut microbiome and immune system shape cancer development and therapy response-an important recognition of his innovative work
Ethics in healthcare ML matters.
We balance performance with values: FAIR data use, transparent algorithms, clinician–patient co-design, and clear documentation.
Trust isn’t just technical—it’s human.
#EthicalAI #FAIRscience #ResponsibleInnovation
We balance performance with values: FAIR data use, transparent algorithms, clinician–patient co-design, and clear documentation.
Trust isn’t just technical—it’s human.
#EthicalAI #FAIRscience #ResponsibleInnovation
November 21, 2025 at 11:38 AM
Ethics in healthcare ML matters.
We balance performance with values: FAIR data use, transparent algorithms, clinician–patient co-design, and clear documentation.
Trust isn’t just technical—it’s human.
#EthicalAI #FAIRscience #ResponsibleInnovation
We balance performance with values: FAIR data use, transparent algorithms, clinician–patient co-design, and clear documentation.
Trust isn’t just technical—it’s human.
#EthicalAI #FAIRscience #ResponsibleInnovation
🧬 Machine learning (ML) pipeline: from blood sample to prediction.
Processes blood omics data to flag high-risk RA and lupus profiles.
🧪 Trained on thousands
📈 Tested across cohorts
✅ Explainable results
Early detection, reimagined — with real-world clinical utility.
Processes blood omics data to flag high-risk RA and lupus profiles.
🧪 Trained on thousands
📈 Tested across cohorts
✅ Explainable results
Early detection, reimagined — with real-world clinical utility.
November 7, 2025 at 2:06 PM
🧬 Machine learning (ML) pipeline: from blood sample to prediction.
Processes blood omics data to flag high-risk RA and lupus profiles.
🧪 Trained on thousands
📈 Tested across cohorts
✅ Explainable results
Early detection, reimagined — with real-world clinical utility.
Processes blood omics data to flag high-risk RA and lupus profiles.
🧪 Trained on thousands
📈 Tested across cohorts
✅ Explainable results
Early detection, reimagined — with real-world clinical utility.
Great to see the DoCTIS Atlas on therapeutic drug response across IMIDs presented at #ACR2025! 🧬
Built in the EU project doctis.eu
, this work earned an Excellence in Research Award and now feeds into DarkMatter - Congratulations Toni Julià!
— AI for immune prediction.
#AI4Health #IMIDs
Built in the EU project doctis.eu
, this work earned an Excellence in Research Award and now feeds into DarkMatter - Congratulations Toni Julià!
— AI for immune prediction.
#AI4Health #IMIDs
October 27, 2025 at 10:00 AM
Great to see the DoCTIS Atlas on therapeutic drug response across IMIDs presented at #ACR2025! 🧬
Built in the EU project doctis.eu
, this work earned an Excellence in Research Award and now feeds into DarkMatter - Congratulations Toni Julià!
— AI for immune prediction.
#AI4Health #IMIDs
Built in the EU project doctis.eu
, this work earned an Excellence in Research Award and now feeds into DarkMatter - Congratulations Toni Julià!
— AI for immune prediction.
#AI4Health #IMIDs
AI for immune disease? We’re building the tools.
ML is transforming how we predict and treat immune-mediated disease.
At ID-DarkMatter-NCD, we’re creating explainable tools to:
🧬 Spot risk early
📊 Predict response
💡 Personalize care
Transparent. Data-driven. Real patients.
ML is transforming how we predict and treat immune-mediated disease.
At ID-DarkMatter-NCD, we’re creating explainable tools to:
🧬 Spot risk early
📊 Predict response
💡 Personalize care
Transparent. Data-driven. Real patients.
October 17, 2025 at 6:40 AM
AI for immune disease? We’re building the tools.
ML is transforming how we predict and treat immune-mediated disease.
At ID-DarkMatter-NCD, we’re creating explainable tools to:
🧬 Spot risk early
📊 Predict response
💡 Personalize care
Transparent. Data-driven. Real patients.
ML is transforming how we predict and treat immune-mediated disease.
At ID-DarkMatter-NCD, we’re creating explainable tools to:
🧬 Spot risk early
📊 Predict response
💡 Personalize care
Transparent. Data-driven. Real patients.
Microbiota patterns may predict disease flares 🦠
In our #IBD research, microbes 📉 vanish before a flare & 📈 bloom during inflammation. Stool #MicrobiomeBiomarkers may give early warnings in #Crohns & #UlcerativeColitis — moving us toward predictive, not just reactive, medicine.
In our #IBD research, microbes 📉 vanish before a flare & 📈 bloom during inflammation. Stool #MicrobiomeBiomarkers may give early warnings in #Crohns & #UlcerativeColitis — moving us toward predictive, not just reactive, medicine.
September 19, 2025 at 10:37 AM
Microbiota patterns may predict disease flares 🦠
In our #IBD research, microbes 📉 vanish before a flare & 📈 bloom during inflammation. Stool #MicrobiomeBiomarkers may give early warnings in #Crohns & #UlcerativeColitis — moving us toward predictive, not just reactive, medicine.
In our #IBD research, microbes 📉 vanish before a flare & 📈 bloom during inflammation. Stool #MicrobiomeBiomarkers may give early warnings in #Crohns & #UlcerativeColitis — moving us toward predictive, not just reactive, medicine.
Rebalancing immunity may mean restoring harmony instead of fighting inflammation.
We’re testing microbiome tools:
🥦 diet,
💊 probiotics,
💩 FMT,
to calm the immune system, reduce symptoms & improve regulation in IBD & MS.
#FMT #MicrobiomeTherapy #DarkMatterProject
We’re testing microbiome tools:
🥦 diet,
💊 probiotics,
💩 FMT,
to calm the immune system, reduce symptoms & improve regulation in IBD & MS.
#FMT #MicrobiomeTherapy #DarkMatterProject
September 5, 2025 at 5:49 AM
Rebalancing immunity may mean restoring harmony instead of fighting inflammation.
We’re testing microbiome tools:
🥦 diet,
💊 probiotics,
💩 FMT,
to calm the immune system, reduce symptoms & improve regulation in IBD & MS.
#FMT #MicrobiomeTherapy #DarkMatterProject
We’re testing microbiome tools:
🥦 diet,
💊 probiotics,
💩 FMT,
to calm the immune system, reduce symptoms & improve regulation in IBD & MS.
#FMT #MicrobiomeTherapy #DarkMatterProject
🚀 Science gave us Antimatter and Dark Matter.
Now there’s even Doesn’t Matter — with no effect on the universe.
But in the DarkMatter Project, we’re all about what matters:
💡 Empowering citizens
❤️ Preventing disease
🌍 Building healthier futures
#DarkMatterEU #Health #CitizenEngagement #Prevention
Now there’s even Doesn’t Matter — with no effect on the universe.
But in the DarkMatter Project, we’re all about what matters:
💡 Empowering citizens
❤️ Preventing disease
🌍 Building healthier futures
#DarkMatterEU #Health #CitizenEngagement #Prevention
September 1, 2025 at 9:49 AM
🚀 Science gave us Antimatter and Dark Matter.
Now there’s even Doesn’t Matter — with no effect on the universe.
But in the DarkMatter Project, we’re all about what matters:
💡 Empowering citizens
❤️ Preventing disease
🌍 Building healthier futures
#DarkMatterEU #Health #CitizenEngagement #Prevention
Now there’s even Doesn’t Matter — with no effect on the universe.
But in the DarkMatter Project, we’re all about what matters:
💡 Empowering citizens
❤️ Preventing disease
🌍 Building healthier futures
#DarkMatterEU #Health #CitizenEngagement #Prevention
Gut feeling: Your microbes might drive your immune system.
Some bacteria trigger flare-ups, others calm inflammation.
At ID-DarkMatter-NCD, we map the gut-immune axis to predict and prevent IBD, MS, lupus & more.
#Microbiome #GutHealth #Autoimmunity #DarkMatterProject
Some bacteria trigger flare-ups, others calm inflammation.
At ID-DarkMatter-NCD, we map the gut-immune axis to predict and prevent IBD, MS, lupus & more.
#Microbiome #GutHealth #Autoimmunity #DarkMatterProject
August 29, 2025 at 6:28 AM
Gut feeling: Your microbes might drive your immune system.
Some bacteria trigger flare-ups, others calm inflammation.
At ID-DarkMatter-NCD, we map the gut-immune axis to predict and prevent IBD, MS, lupus & more.
#Microbiome #GutHealth #Autoimmunity #DarkMatterProject
Some bacteria trigger flare-ups, others calm inflammation.
At ID-DarkMatter-NCD, we map the gut-immune axis to predict and prevent IBD, MS, lupus & more.
#Microbiome #GutHealth #Autoimmunity #DarkMatterProject
Autoimmunity isn’t about a “strong” immune system—it’s about a misdirected one. At ID-DarkMatter-NCD we use AI + multi-omics to design precision therapies, moving from trial-and-error medicine to tailored immunomodulation.
#PrecisionMedicine
#PrecisionMedicine
August 21, 2025 at 10:43 AM
Autoimmunity isn’t about a “strong” immune system—it’s about a misdirected one. At ID-DarkMatter-NCD we use AI + multi-omics to design precision therapies, moving from trial-and-error medicine to tailored immunomodulation.
#PrecisionMedicine
#PrecisionMedicine
Meet Dr Thomas Vogl, coordinator of Horizon Europe #DarkMatterEU & group leader at MedUni Vienna. At #IUIS2025 he’ll reveal how antibody repertoires unlock immune–microbiome secrets in health & disease. 🌍🔬 Learn more: loom.ly/CwagY2g
August 14, 2025 at 8:48 AM
Meet Dr Thomas Vogl, coordinator of Horizon Europe #DarkMatterEU & group leader at MedUni Vienna. At #IUIS2025 he’ll reveal how antibody repertoires unlock immune–microbiome secrets in health & disease. 🌍🔬 Learn more: loom.ly/CwagY2g
Post 1/6
🧬 Big news for #MECFS research.
The DecodeME study — the world’s largest genetic investigation into ME/CFS — just found 8 genetic regions linked to the illness. Many involve immune response + chronic pain pathways.
🧬 Big news for #MECFS research.
The DecodeME study — the world’s largest genetic investigation into ME/CFS — just found 8 genetic regions linked to the illness. Many involve immune response + chronic pain pathways.
August 13, 2025 at 7:11 AM
Post 1/6
🧬 Big news for #MECFS research.
The DecodeME study — the world’s largest genetic investigation into ME/CFS — just found 8 genetic regions linked to the illness. Many involve immune response + chronic pain pathways.
🧬 Big news for #MECFS research.
The DecodeME study — the world’s largest genetic investigation into ME/CFS — just found 8 genetic regions linked to the illness. Many involve immune response + chronic pain pathways.
Tolerogenic vaccines don’t activate immunity—they teach it tolerance. At ID-DarkMatter-NCD, we design nanoparticle vaccines to retrain immune cells, preventing flare-ups in diseases like RA & IBD. Immune peacekeeping, not brute force. #Autoimmunity #NextGenTherapies #DarkMatterProject
August 8, 2025 at 7:39 AM
Tolerogenic vaccines don’t activate immunity—they teach it tolerance. At ID-DarkMatter-NCD, we design nanoparticle vaccines to retrain immune cells, preventing flare-ups in diseases like RA & IBD. Immune peacekeeping, not brute force. #Autoimmunity #NextGenTherapies #DarkMatterProject
CAR-T for Autoimmune Disease? It’s real—and it’s precise.
You’ve seen CAR-T revolutionise cancer care. Now it’s being tested in RA, lupus & MS.
🔬 Custom T-cells
🎯 Targeting only auto reactive cells
🔥 Less inflammation, fewer side effects
No more immune sledgehammers—this is a scalpel.
#DarkMatterNCD
You’ve seen CAR-T revolutionise cancer care. Now it’s being tested in RA, lupus & MS.
🔬 Custom T-cells
🎯 Targeting only auto reactive cells
🔥 Less inflammation, fewer side effects
No more immune sledgehammers—this is a scalpel.
#DarkMatterNCD
July 28, 2025 at 7:09 AM
CAR-T for Autoimmune Disease? It’s real—and it’s precise.
You’ve seen CAR-T revolutionise cancer care. Now it’s being tested in RA, lupus & MS.
🔬 Custom T-cells
🎯 Targeting only auto reactive cells
🔥 Less inflammation, fewer side effects
No more immune sledgehammers—this is a scalpel.
#DarkMatterNCD
You’ve seen CAR-T revolutionise cancer care. Now it’s being tested in RA, lupus & MS.
🔬 Custom T-cells
🎯 Targeting only auto reactive cells
🔥 Less inflammation, fewer side effects
No more immune sledgehammers—this is a scalpel.
#DarkMatterNCD
What if the immune system could be reprogrammed to heal itself?
At ID-DarkMatter-NCD, we’re exploring immune retraining instead of suppression — using biologics, gene & cell therapy to restore balance in RA, lupus, MS & more.
#Autoimmune #Immunotherapy #DarkMatterProject
At ID-DarkMatter-NCD, we’re exploring immune retraining instead of suppression — using biologics, gene & cell therapy to restore balance in RA, lupus, MS & more.
#Autoimmune #Immunotherapy #DarkMatterProject
July 18, 2025 at 5:59 AM
What if the immune system could be reprogrammed to heal itself?
At ID-DarkMatter-NCD, we’re exploring immune retraining instead of suppression — using biologics, gene & cell therapy to restore balance in RA, lupus, MS & more.
#Autoimmune #Immunotherapy #DarkMatterProject
At ID-DarkMatter-NCD, we’re exploring immune retraining instead of suppression — using biologics, gene & cell therapy to restore balance in RA, lupus, MS & more.
#Autoimmune #Immunotherapy #DarkMatterProject
Next-gen immunotherapies at ID-DarkMatter-NCD aim to retrain the immune system to heal, not harm. 💉🦠 From CAR-T to microbiome tools, we’re tackling RA, lupus & more with precision! #Autoimmune #Immunotherapy #DarkMatterProject
July 11, 2025 at 6:06 AM
Next-gen immunotherapies at ID-DarkMatter-NCD aim to retrain the immune system to heal, not harm. 💉🦠 From CAR-T to microbiome tools, we’re tackling RA, lupus & more with precision! #Autoimmune #Immunotherapy #DarkMatterProject
🧬 The epigenome rewrites disease risk.
Stress, diet & infections can flip genes on/off without altering DNA.
Can we reverse autoimmune risk by targeting epigenetics?
At ID-DarkMatter-NCD, we’re finding out.
#Epigenetics #ImmuneHealth
Stress, diet & infections can flip genes on/off without altering DNA.
Can we reverse autoimmune risk by targeting epigenetics?
At ID-DarkMatter-NCD, we’re finding out.
#Epigenetics #ImmuneHealth
July 4, 2025 at 9:47 AM
🧬 The epigenome rewrites disease risk.
Stress, diet & infections can flip genes on/off without altering DNA.
Can we reverse autoimmune risk by targeting epigenetics?
At ID-DarkMatter-NCD, we’re finding out.
#Epigenetics #ImmuneHealth
Stress, diet & infections can flip genes on/off without altering DNA.
Can we reverse autoimmune risk by targeting epigenetics?
At ID-DarkMatter-NCD, we’re finding out.
#Epigenetics #ImmuneHealth
🔬 The Power of Multi-Omics: A 360° view of disease!
At ID-DarkMatter-NCD, we merge genomics, metagenomics, proteomics & metabolomics to reveal hidden drivers & enable precision medicine for IBD, MS & lupus. #MultiOmics #PrecisionMedicine #DarkMatterProject #BiomedicalInnovation
At ID-DarkMatter-NCD, we merge genomics, metagenomics, proteomics & metabolomics to reveal hidden drivers & enable precision medicine for IBD, MS & lupus. #MultiOmics #PrecisionMedicine #DarkMatterProject #BiomedicalInnovation
June 27, 2025 at 11:19 AM
🔬 The Power of Multi-Omics: A 360° view of disease!
At ID-DarkMatter-NCD, we merge genomics, metagenomics, proteomics & metabolomics to reveal hidden drivers & enable precision medicine for IBD, MS & lupus. #MultiOmics #PrecisionMedicine #DarkMatterProject #BiomedicalInnovation
At ID-DarkMatter-NCD, we merge genomics, metagenomics, proteomics & metabolomics to reveal hidden drivers & enable precision medicine for IBD, MS & lupus. #MultiOmics #PrecisionMedicine #DarkMatterProject #BiomedicalInnovation
🌟 Back from #EULAR2025 inspired!
🏅 Antonio Juliá wins Abstract Award for single-cell insights (DoCTIS)
🎤 Diane van der Woude on predicting RA before symptoms
🔬 DarkMatter’s mission—early detection & stratification—gains momentum.
#PrecisionMedicine #Autoimmunity
🏅 Antonio Juliá wins Abstract Award for single-cell insights (DoCTIS)
🎤 Diane van der Woude on predicting RA before symptoms
🔬 DarkMatter’s mission—early detection & stratification—gains momentum.
#PrecisionMedicine #Autoimmunity
June 20, 2025 at 7:04 AM
🌟 Back from #EULAR2025 inspired!
🏅 Antonio Juliá wins Abstract Award for single-cell insights (DoCTIS)
🎤 Diane van der Woude on predicting RA before symptoms
🔬 DarkMatter’s mission—early detection & stratification—gains momentum.
#PrecisionMedicine #Autoimmunity
🏅 Antonio Juliá wins Abstract Award for single-cell insights (DoCTIS)
🎤 Diane van der Woude on predicting RA before symptoms
🔬 DarkMatter’s mission—early detection & stratification—gains momentum.
#PrecisionMedicine #Autoimmunity
Big congrats to Antonio Julià (Vall d'Hebron) for winning the EULAR 2025 Abstract Award! 🏆 His DoCTIS study maps molecular variation across 6 IMIDs via single-cell RNAseq — paving the way for precision medicine! 👏 Talk: June 13, 10:30 CEST #EULAR2025 #DarkMatter
June 12, 2025 at 6:32 AM
Big congrats to Antonio Julià (Vall d'Hebron) for winning the EULAR 2025 Abstract Award! 🏆 His DoCTIS study maps molecular variation across 6 IMIDs via single-cell RNAseq — paving the way for precision medicine! 👏 Talk: June 13, 10:30 CEST #EULAR2025 #DarkMatter
🎤 Why is "Difficult-to-treat RA" so difficult to treat? And what can we do?
🗓 Thurs 12 June | 🕒 15:45–17:00 |Room A2 | #EULAR2025
Join #DarkMatter Partner Diane van der Woude + experts:
🧠 why some RA patients remain hard to treat
🧬 neuro-immunological approaches
🧰 case-based insights
See you there!
🗓 Thurs 12 June | 🕒 15:45–17:00 |Room A2 | #EULAR2025
Join #DarkMatter Partner Diane van der Woude + experts:
🧠 why some RA patients remain hard to treat
🧬 neuro-immunological approaches
🧰 case-based insights
See you there!
June 10, 2025 at 11:57 AM
🎤 Why is "Difficult-to-treat RA" so difficult to treat? And what can we do?
🗓 Thurs 12 June | 🕒 15:45–17:00 |Room A2 | #EULAR2025
Join #DarkMatter Partner Diane van der Woude + experts:
🧠 why some RA patients remain hard to treat
🧬 neuro-immunological approaches
🧰 case-based insights
See you there!
🗓 Thurs 12 June | 🕒 15:45–17:00 |Room A2 | #EULAR2025
Join #DarkMatter Partner Diane van der Woude + experts:
🧠 why some RA patients remain hard to treat
🧬 neuro-immunological approaches
🧰 case-based insights
See you there!
🔬 What if we could detect autoimmune diseases before symptoms appear?
DarkMatter is pioneering early diagnosis with cutting-edge biomarkers.
Early action = better outcomes.
Tag someone in healthtech!
#Biomarkers #EarlyDetection #DarkMatterProject
DarkMatter is pioneering early diagnosis with cutting-edge biomarkers.
Early action = better outcomes.
Tag someone in healthtech!
#Biomarkers #EarlyDetection #DarkMatterProject
June 6, 2025 at 6:24 AM
🔬 What if we could detect autoimmune diseases before symptoms appear?
DarkMatter is pioneering early diagnosis with cutting-edge biomarkers.
Early action = better outcomes.
Tag someone in healthtech!
#Biomarkers #EarlyDetection #DarkMatterProject
DarkMatter is pioneering early diagnosis with cutting-edge biomarkers.
Early action = better outcomes.
Tag someone in healthtech!
#Biomarkers #EarlyDetection #DarkMatterProject
🤖🏛️ AI is transforming medicine, but can we ensure fairness, privacy & accountability?
Key concerns:
✔️ Bias in AI
✔️ Data privacy
✔️ Human validation of diagnoses
Should AI diagnoses need human review? Let’s discuss!
#AIethics #DarkMatterNCD #BiomedicalAI
Key concerns:
✔️ Bias in AI
✔️ Data privacy
✔️ Human validation of diagnoses
Should AI diagnoses need human review? Let’s discuss!
#AIethics #DarkMatterNCD #BiomedicalAI
May 30, 2025 at 7:19 AM
🤖🏛️ AI is transforming medicine, but can we ensure fairness, privacy & accountability?
Key concerns:
✔️ Bias in AI
✔️ Data privacy
✔️ Human validation of diagnoses
Should AI diagnoses need human review? Let’s discuss!
#AIethics #DarkMatterNCD #BiomedicalAI
Key concerns:
✔️ Bias in AI
✔️ Data privacy
✔️ Human validation of diagnoses
Should AI diagnoses need human review? Let’s discuss!
#AIethics #DarkMatterNCD #BiomedicalAI
🦠 Could your gut hold the key to autoimmune diseases?
At ID-DarkMatter-NCD, we’re exploring how gut bacteria imbalances link to IBD, MS & RA.
Gut health = immune health 💙
#GutHealth #MicrobiomeScience #NCDResearch #BiomedicalInnovation
At ID-DarkMatter-NCD, we’re exploring how gut bacteria imbalances link to IBD, MS & RA.
Gut health = immune health 💙
#GutHealth #MicrobiomeScience #NCDResearch #BiomedicalInnovation
May 23, 2025 at 6:44 AM
🦠 Could your gut hold the key to autoimmune diseases?
At ID-DarkMatter-NCD, we’re exploring how gut bacteria imbalances link to IBD, MS & RA.
Gut health = immune health 💙
#GutHealth #MicrobiomeScience #NCDResearch #BiomedicalInnovation
At ID-DarkMatter-NCD, we’re exploring how gut bacteria imbalances link to IBD, MS & RA.
Gut health = immune health 💙
#GutHealth #MicrobiomeScience #NCDResearch #BiomedicalInnovation
🔬 Dark Matter & 5 Horizon Europe sibling projects—EBV-MS, BEAT-sepsis, CLARITY, POINT & COMMUTE—are uniting to study how infections drive NCDs. From EBV to COVID-19, we're sharing data, tools & science to uncover long-term impacts. #IDsinNCDs #DarkMatterProject #HorizonEurope
May 14, 2025 at 11:01 AM
🔬 Dark Matter & 5 Horizon Europe sibling projects—EBV-MS, BEAT-sepsis, CLARITY, POINT & COMMUTE—are uniting to study how infections drive NCDs. From EBV to COVID-19, we're sharing data, tools & science to uncover long-term impacts. #IDsinNCDs #DarkMatterProject #HorizonEurope