Dark Matter Project
@id-darkmatter-ncd.bsky.social
The ID-DarkMatter-NCD Project is a Horizon Europe funded project to study immune related non-communicable disease (NCDs), unraveling the Dark Matter of infectious diseases, environmental and genetic factors tipping the balance towards NCDs.
Thomas Vogl, group leader at MedUni Vienna and coordinator of the DarkMatter project, has been selected for the EMBO Young Investigator Programme. His team explores how the gut microbiome and immune system shape cancer development and therapy response-an important recognition of his innovative work
December 4, 2025 at 7:40 AM
Thomas Vogl, group leader at MedUni Vienna and coordinator of the DarkMatter project, has been selected for the EMBO Young Investigator Programme. His team explores how the gut microbiome and immune system shape cancer development and therapy response-an important recognition of his innovative work
MACHINE LEARNING & PREDICTION- Our pipeline will be open-source
Science moves faster when we share.
We’re preparing to release our ML pipeline on GitHub, with:
🛠️ Clear documentation
🔄 Sample datasets
🤝 FAIR, reproducible architecture
We hope others build on it. We welcome collaborators.
Science moves faster when we share.
We’re preparing to release our ML pipeline on GitHub, with:
🛠️ Clear documentation
🔄 Sample datasets
🤝 FAIR, reproducible architecture
We hope others build on it. We welcome collaborators.
November 28, 2025 at 6:55 AM
MACHINE LEARNING & PREDICTION- Our pipeline will be open-source
Science moves faster when we share.
We’re preparing to release our ML pipeline on GitHub, with:
🛠️ Clear documentation
🔄 Sample datasets
🤝 FAIR, reproducible architecture
We hope others build on it. We welcome collaborators.
Science moves faster when we share.
We’re preparing to release our ML pipeline on GitHub, with:
🛠️ Clear documentation
🔄 Sample datasets
🤝 FAIR, reproducible architecture
We hope others build on it. We welcome collaborators.
Ethics in healthcare ML matters.
We balance performance with values: FAIR data use, transparent algorithms, clinician–patient co-design, and clear documentation.
Trust isn’t just technical—it’s human.
#EthicalAI #FAIRscience #ResponsibleInnovation
We balance performance with values: FAIR data use, transparent algorithms, clinician–patient co-design, and clear documentation.
Trust isn’t just technical—it’s human.
#EthicalAI #FAIRscience #ResponsibleInnovation
November 21, 2025 at 11:38 AM
Ethics in healthcare ML matters.
We balance performance with values: FAIR data use, transparent algorithms, clinician–patient co-design, and clear documentation.
Trust isn’t just technical—it’s human.
#EthicalAI #FAIRscience #ResponsibleInnovation
We balance performance with values: FAIR data use, transparent algorithms, clinician–patient co-design, and clear documentation.
Trust isn’t just technical—it’s human.
#EthicalAI #FAIRscience #ResponsibleInnovation
🧬 Machine learning (ML) pipeline: from blood sample to prediction.
Processes blood omics data to flag high-risk RA and lupus profiles.
🧪 Trained on thousands
📈 Tested across cohorts
✅ Explainable results
Early detection, reimagined — with real-world clinical utility.
Processes blood omics data to flag high-risk RA and lupus profiles.
🧪 Trained on thousands
📈 Tested across cohorts
✅ Explainable results
Early detection, reimagined — with real-world clinical utility.
November 7, 2025 at 2:06 PM
🧬 Machine learning (ML) pipeline: from blood sample to prediction.
Processes blood omics data to flag high-risk RA and lupus profiles.
🧪 Trained on thousands
📈 Tested across cohorts
✅ Explainable results
Early detection, reimagined — with real-world clinical utility.
Processes blood omics data to flag high-risk RA and lupus profiles.
🧪 Trained on thousands
📈 Tested across cohorts
✅ Explainable results
Early detection, reimagined — with real-world clinical utility.
Great to see the DoCTIS Atlas on therapeutic drug response across IMIDs presented at #ACR2025! 🧬
Built in the EU project doctis.eu
, this work earned an Excellence in Research Award and now feeds into DarkMatter - Congratulations Toni Julià!
— AI for immune prediction.
#AI4Health #IMIDs
Built in the EU project doctis.eu
, this work earned an Excellence in Research Award and now feeds into DarkMatter - Congratulations Toni Julià!
— AI for immune prediction.
#AI4Health #IMIDs
October 27, 2025 at 10:00 AM
Great to see the DoCTIS Atlas on therapeutic drug response across IMIDs presented at #ACR2025! 🧬
Built in the EU project doctis.eu
, this work earned an Excellence in Research Award and now feeds into DarkMatter - Congratulations Toni Julià!
— AI for immune prediction.
#AI4Health #IMIDs
Built in the EU project doctis.eu
, this work earned an Excellence in Research Award and now feeds into DarkMatter - Congratulations Toni Julià!
— AI for immune prediction.
#AI4Health #IMIDs
AI for immune disease? We’re building the tools.
ML is transforming how we predict and treat immune-mediated disease.
At ID-DarkMatter-NCD, we’re creating explainable tools to:
🧬 Spot risk early
📊 Predict response
💡 Personalize care
Transparent. Data-driven. Real patients.
ML is transforming how we predict and treat immune-mediated disease.
At ID-DarkMatter-NCD, we’re creating explainable tools to:
🧬 Spot risk early
📊 Predict response
💡 Personalize care
Transparent. Data-driven. Real patients.
October 17, 2025 at 6:40 AM
AI for immune disease? We’re building the tools.
ML is transforming how we predict and treat immune-mediated disease.
At ID-DarkMatter-NCD, we’re creating explainable tools to:
🧬 Spot risk early
📊 Predict response
💡 Personalize care
Transparent. Data-driven. Real patients.
ML is transforming how we predict and treat immune-mediated disease.
At ID-DarkMatter-NCD, we’re creating explainable tools to:
🧬 Spot risk early
📊 Predict response
💡 Personalize care
Transparent. Data-driven. Real patients.
World Arthritis Day 2025
For 1 in 5 people with Rheumatoid Arthritis, treatments stop working — leaving pain, fatigue & uncertainty. MDR-RA studies why therapies fail and develops tools for personalised care.
With patients, we aim to turn #RMDreams into reality.
For 1 in 5 people with Rheumatoid Arthritis, treatments stop working — leaving pain, fatigue & uncertainty. MDR-RA studies why therapies fail and develops tools for personalised care.
With patients, we aim to turn #RMDreams into reality.
world-arthritis-day-2025 | EULAR
www.eular.org
October 2, 2025 at 12:40 PM
World Arthritis Day 2025
For 1 in 5 people with Rheumatoid Arthritis, treatments stop working — leaving pain, fatigue & uncertainty. MDR-RA studies why therapies fail and develops tools for personalised care.
With patients, we aim to turn #RMDreams into reality.
For 1 in 5 people with Rheumatoid Arthritis, treatments stop working — leaving pain, fatigue & uncertainty. MDR-RA studies why therapies fail and develops tools for personalised care.
With patients, we aim to turn #RMDreams into reality.
Microbiota patterns may predict disease flares 🦠
In our #IBD research, microbes 📉 vanish before a flare & 📈 bloom during inflammation. Stool #MicrobiomeBiomarkers may give early warnings in #Crohns & #UlcerativeColitis — moving us toward predictive, not just reactive, medicine.
In our #IBD research, microbes 📉 vanish before a flare & 📈 bloom during inflammation. Stool #MicrobiomeBiomarkers may give early warnings in #Crohns & #UlcerativeColitis — moving us toward predictive, not just reactive, medicine.
September 19, 2025 at 10:37 AM
Microbiota patterns may predict disease flares 🦠
In our #IBD research, microbes 📉 vanish before a flare & 📈 bloom during inflammation. Stool #MicrobiomeBiomarkers may give early warnings in #Crohns & #UlcerativeColitis — moving us toward predictive, not just reactive, medicine.
In our #IBD research, microbes 📉 vanish before a flare & 📈 bloom during inflammation. Stool #MicrobiomeBiomarkers may give early warnings in #Crohns & #UlcerativeColitis — moving us toward predictive, not just reactive, medicine.
Rebalancing immunity may mean restoring harmony instead of fighting inflammation.
We’re testing microbiome tools:
🥦 diet,
💊 probiotics,
💩 FMT,
to calm the immune system, reduce symptoms & improve regulation in IBD & MS.
#FMT #MicrobiomeTherapy #DarkMatterProject
We’re testing microbiome tools:
🥦 diet,
💊 probiotics,
💩 FMT,
to calm the immune system, reduce symptoms & improve regulation in IBD & MS.
#FMT #MicrobiomeTherapy #DarkMatterProject
September 5, 2025 at 5:49 AM
Rebalancing immunity may mean restoring harmony instead of fighting inflammation.
We’re testing microbiome tools:
🥦 diet,
💊 probiotics,
💩 FMT,
to calm the immune system, reduce symptoms & improve regulation in IBD & MS.
#FMT #MicrobiomeTherapy #DarkMatterProject
We’re testing microbiome tools:
🥦 diet,
💊 probiotics,
💩 FMT,
to calm the immune system, reduce symptoms & improve regulation in IBD & MS.
#FMT #MicrobiomeTherapy #DarkMatterProject
🚀 Science gave us Antimatter and Dark Matter.
Now there’s even Doesn’t Matter — with no effect on the universe.
But in the DarkMatter Project, we’re all about what matters:
💡 Empowering citizens
❤️ Preventing disease
🌍 Building healthier futures
#DarkMatterEU #Health #CitizenEngagement #Prevention
Now there’s even Doesn’t Matter — with no effect on the universe.
But in the DarkMatter Project, we’re all about what matters:
💡 Empowering citizens
❤️ Preventing disease
🌍 Building healthier futures
#DarkMatterEU #Health #CitizenEngagement #Prevention
September 1, 2025 at 9:49 AM
🚀 Science gave us Antimatter and Dark Matter.
Now there’s even Doesn’t Matter — with no effect on the universe.
But in the DarkMatter Project, we’re all about what matters:
💡 Empowering citizens
❤️ Preventing disease
🌍 Building healthier futures
#DarkMatterEU #Health #CitizenEngagement #Prevention
Now there’s even Doesn’t Matter — with no effect on the universe.
But in the DarkMatter Project, we’re all about what matters:
💡 Empowering citizens
❤️ Preventing disease
🌍 Building healthier futures
#DarkMatterEU #Health #CitizenEngagement #Prevention
Gut feeling: Your microbes might drive your immune system.
Some bacteria trigger flare-ups, others calm inflammation.
At ID-DarkMatter-NCD, we map the gut-immune axis to predict and prevent IBD, MS, lupus & more.
#Microbiome #GutHealth #Autoimmunity #DarkMatterProject
Some bacteria trigger flare-ups, others calm inflammation.
At ID-DarkMatter-NCD, we map the gut-immune axis to predict and prevent IBD, MS, lupus & more.
#Microbiome #GutHealth #Autoimmunity #DarkMatterProject
August 29, 2025 at 6:28 AM
Gut feeling: Your microbes might drive your immune system.
Some bacteria trigger flare-ups, others calm inflammation.
At ID-DarkMatter-NCD, we map the gut-immune axis to predict and prevent IBD, MS, lupus & more.
#Microbiome #GutHealth #Autoimmunity #DarkMatterProject
Some bacteria trigger flare-ups, others calm inflammation.
At ID-DarkMatter-NCD, we map the gut-immune axis to predict and prevent IBD, MS, lupus & more.
#Microbiome #GutHealth #Autoimmunity #DarkMatterProject
Autoimmunity isn’t about a “strong” immune system—it’s about a misdirected one. At ID-DarkMatter-NCD we use AI + multi-omics to design precision therapies, moving from trial-and-error medicine to tailored immunomodulation.
#PrecisionMedicine
#PrecisionMedicine
August 21, 2025 at 10:43 AM
Autoimmunity isn’t about a “strong” immune system—it’s about a misdirected one. At ID-DarkMatter-NCD we use AI + multi-omics to design precision therapies, moving from trial-and-error medicine to tailored immunomodulation.
#PrecisionMedicine
#PrecisionMedicine
Meet Dr Thomas Vogl, coordinator of Horizon Europe #DarkMatterEU & group leader at MedUni Vienna. At #IUIS2025 he’ll reveal how antibody repertoires unlock immune–microbiome secrets in health & disease. 🌍🔬 Learn more: loom.ly/CwagY2g
August 14, 2025 at 8:48 AM
Meet Dr Thomas Vogl, coordinator of Horizon Europe #DarkMatterEU & group leader at MedUni Vienna. At #IUIS2025 he’ll reveal how antibody repertoires unlock immune–microbiome secrets in health & disease. 🌍🔬 Learn more: loom.ly/CwagY2g
Post 6/6
ME/CFS research is finally entering a new era — one where patient voices, large-scale data & cutting-edge science work together.
#DecodeME #MECFS #Genomics #DarkMatter
ME/CFS research is finally entering a new era — one where patient voices, large-scale data & cutting-edge science work together.
#DecodeME #MECFS #Genomics #DarkMatter
August 13, 2025 at 7:13 AM
Post 6/6
ME/CFS research is finally entering a new era — one where patient voices, large-scale data & cutting-edge science work together.
#DecodeME #MECFS #Genomics #DarkMatter
ME/CFS research is finally entering a new era — one where patient voices, large-scale data & cutting-edge science work together.
#DecodeME #MECFS #Genomics #DarkMatter
Post 5/6
🔍 Linking DecodeME’s findings to regulatory genomics could reveal why these genetic regions matter — and how to target them for diagnostics & therapies.
🔍 Linking DecodeME’s findings to regulatory genomics could reveal why these genetic regions matter — and how to target them for diagnostics & therapies.
August 13, 2025 at 7:12 AM
Post 5/6
🔍 Linking DecodeME’s findings to regulatory genomics could reveal why these genetic regions matter — and how to target them for diagnostics & therapies.
🔍 Linking DecodeME’s findings to regulatory genomics could reveal why these genetic regions matter — and how to target them for diagnostics & therapies.
Post 4/6
At Dark Matter, we’re taking this further.
We study the “dark matter” of the genome — the 98% that doesn’t code for proteins — to see how it regulates immune & nervous system function in ME/CFS.
At Dark Matter, we’re taking this further.
We study the “dark matter” of the genome — the 98% that doesn’t code for proteins — to see how it regulates immune & nervous system function in ME/CFS.
August 13, 2025 at 7:12 AM
Post 4/6
At Dark Matter, we’re taking this further.
We study the “dark matter” of the genome — the 98% that doesn’t code for proteins — to see how it regulates immune & nervous system function in ME/CFS.
At Dark Matter, we’re taking this further.
We study the “dark matter” of the genome — the 98% that doesn’t code for proteins — to see how it regulates immune & nervous system function in ME/CFS.
Post 3/6
DecodeME analysed DNA from 15,000+ people with ME/CFS vs. ~260,000 controls.
This is the first robust genetic evidence for ME/CFS risk — a huge step toward reducing stigma + guiding treatment research.
DecodeME analysed DNA from 15,000+ people with ME/CFS vs. ~260,000 controls.
This is the first robust genetic evidence for ME/CFS risk — a huge step toward reducing stigma + guiding treatment research.
August 13, 2025 at 7:12 AM
Post 3/6
DecodeME analysed DNA from 15,000+ people with ME/CFS vs. ~260,000 controls.
This is the first robust genetic evidence for ME/CFS risk — a huge step toward reducing stigma + guiding treatment research.
DecodeME analysed DNA from 15,000+ people with ME/CFS vs. ~260,000 controls.
This is the first robust genetic evidence for ME/CFS risk — a huge step toward reducing stigma + guiding treatment research.
Post 2/6
ME/CFS affects 67 million people worldwide, often starting after infection and causing post-exertional malaise — worsening of symptoms after even mild activity.
There’s no definitive test & no effective treatment… yet.
ME/CFS affects 67 million people worldwide, often starting after infection and causing post-exertional malaise — worsening of symptoms after even mild activity.
There’s no definitive test & no effective treatment… yet.
August 13, 2025 at 7:11 AM
Post 2/6
ME/CFS affects 67 million people worldwide, often starting after infection and causing post-exertional malaise — worsening of symptoms after even mild activity.
There’s no definitive test & no effective treatment… yet.
ME/CFS affects 67 million people worldwide, often starting after infection and causing post-exertional malaise — worsening of symptoms after even mild activity.
There’s no definitive test & no effective treatment… yet.
Post 1/6
🧬 Big news for #MECFS research.
The DecodeME study — the world’s largest genetic investigation into ME/CFS — just found 8 genetic regions linked to the illness. Many involve immune response + chronic pain pathways.
🧬 Big news for #MECFS research.
The DecodeME study — the world’s largest genetic investigation into ME/CFS — just found 8 genetic regions linked to the illness. Many involve immune response + chronic pain pathways.
August 13, 2025 at 7:11 AM
Post 1/6
🧬 Big news for #MECFS research.
The DecodeME study — the world’s largest genetic investigation into ME/CFS — just found 8 genetic regions linked to the illness. Many involve immune response + chronic pain pathways.
🧬 Big news for #MECFS research.
The DecodeME study — the world’s largest genetic investigation into ME/CFS — just found 8 genetic regions linked to the illness. Many involve immune response + chronic pain pathways.
Tolerogenic vaccines don’t activate immunity—they teach it tolerance. At ID-DarkMatter-NCD, we design nanoparticle vaccines to retrain immune cells, preventing flare-ups in diseases like RA & IBD. Immune peacekeeping, not brute force. #Autoimmunity #NextGenTherapies #DarkMatterProject
August 8, 2025 at 7:39 AM
Tolerogenic vaccines don’t activate immunity—they teach it tolerance. At ID-DarkMatter-NCD, we design nanoparticle vaccines to retrain immune cells, preventing flare-ups in diseases like RA & IBD. Immune peacekeeping, not brute force. #Autoimmunity #NextGenTherapies #DarkMatterProject
CAR-T for Autoimmune Disease? It’s real—and it’s precise.
You’ve seen CAR-T revolutionise cancer care. Now it’s being tested in RA, lupus & MS.
🔬 Custom T-cells
🎯 Targeting only auto reactive cells
🔥 Less inflammation, fewer side effects
No more immune sledgehammers—this is a scalpel.
#DarkMatterNCD
You’ve seen CAR-T revolutionise cancer care. Now it’s being tested in RA, lupus & MS.
🔬 Custom T-cells
🎯 Targeting only auto reactive cells
🔥 Less inflammation, fewer side effects
No more immune sledgehammers—this is a scalpel.
#DarkMatterNCD
July 28, 2025 at 7:09 AM
CAR-T for Autoimmune Disease? It’s real—and it’s precise.
You’ve seen CAR-T revolutionise cancer care. Now it’s being tested in RA, lupus & MS.
🔬 Custom T-cells
🎯 Targeting only auto reactive cells
🔥 Less inflammation, fewer side effects
No more immune sledgehammers—this is a scalpel.
#DarkMatterNCD
You’ve seen CAR-T revolutionise cancer care. Now it’s being tested in RA, lupus & MS.
🔬 Custom T-cells
🎯 Targeting only auto reactive cells
🔥 Less inflammation, fewer side effects
No more immune sledgehammers—this is a scalpel.
#DarkMatterNCD
What if the immune system could be reprogrammed to heal itself?
At ID-DarkMatter-NCD, we’re exploring immune retraining instead of suppression — using biologics, gene & cell therapy to restore balance in RA, lupus, MS & more.
#Autoimmune #Immunotherapy #DarkMatterProject
At ID-DarkMatter-NCD, we’re exploring immune retraining instead of suppression — using biologics, gene & cell therapy to restore balance in RA, lupus, MS & more.
#Autoimmune #Immunotherapy #DarkMatterProject
July 18, 2025 at 5:59 AM
What if the immune system could be reprogrammed to heal itself?
At ID-DarkMatter-NCD, we’re exploring immune retraining instead of suppression — using biologics, gene & cell therapy to restore balance in RA, lupus, MS & more.
#Autoimmune #Immunotherapy #DarkMatterProject
At ID-DarkMatter-NCD, we’re exploring immune retraining instead of suppression — using biologics, gene & cell therapy to restore balance in RA, lupus, MS & more.
#Autoimmune #Immunotherapy #DarkMatterProject
Next-gen immunotherapies at ID-DarkMatter-NCD aim to retrain the immune system to heal, not harm. 💉🦠 From CAR-T to microbiome tools, we’re tackling RA, lupus & more with precision! #Autoimmune #Immunotherapy #DarkMatterProject
July 11, 2025 at 6:06 AM
Next-gen immunotherapies at ID-DarkMatter-NCD aim to retrain the immune system to heal, not harm. 💉🦠 From CAR-T to microbiome tools, we’re tackling RA, lupus & more with precision! #Autoimmune #Immunotherapy #DarkMatterProject
🧬 The epigenome rewrites disease risk.
Stress, diet & infections can flip genes on/off without altering DNA.
Can we reverse autoimmune risk by targeting epigenetics?
At ID-DarkMatter-NCD, we’re finding out.
#Epigenetics #ImmuneHealth
Stress, diet & infections can flip genes on/off without altering DNA.
Can we reverse autoimmune risk by targeting epigenetics?
At ID-DarkMatter-NCD, we’re finding out.
#Epigenetics #ImmuneHealth
July 4, 2025 at 9:47 AM
🧬 The epigenome rewrites disease risk.
Stress, diet & infections can flip genes on/off without altering DNA.
Can we reverse autoimmune risk by targeting epigenetics?
At ID-DarkMatter-NCD, we’re finding out.
#Epigenetics #ImmuneHealth
Stress, diet & infections can flip genes on/off without altering DNA.
Can we reverse autoimmune risk by targeting epigenetics?
At ID-DarkMatter-NCD, we’re finding out.
#Epigenetics #ImmuneHealth
🔬 The Power of Multi-Omics: A 360° view of disease!
At ID-DarkMatter-NCD, we merge genomics, metagenomics, proteomics & metabolomics to reveal hidden drivers & enable precision medicine for IBD, MS & lupus. #MultiOmics #PrecisionMedicine #DarkMatterProject #BiomedicalInnovation
At ID-DarkMatter-NCD, we merge genomics, metagenomics, proteomics & metabolomics to reveal hidden drivers & enable precision medicine for IBD, MS & lupus. #MultiOmics #PrecisionMedicine #DarkMatterProject #BiomedicalInnovation
June 27, 2025 at 11:19 AM
🔬 The Power of Multi-Omics: A 360° view of disease!
At ID-DarkMatter-NCD, we merge genomics, metagenomics, proteomics & metabolomics to reveal hidden drivers & enable precision medicine for IBD, MS & lupus. #MultiOmics #PrecisionMedicine #DarkMatterProject #BiomedicalInnovation
At ID-DarkMatter-NCD, we merge genomics, metagenomics, proteomics & metabolomics to reveal hidden drivers & enable precision medicine for IBD, MS & lupus. #MultiOmics #PrecisionMedicine #DarkMatterProject #BiomedicalInnovation