Ian Sealy
iansealy.com
Ian Sealy
@iansealy.com
Bioinformatician in buschlab.org at qmul.ac.uk. Previously citiid.cam.ac.uk, sanger.ac.uk and bbk.ac.uk. Product of ILRT, Bristol.
Reposted by Ian Sealy
Reposted by Ian Sealy
A Sharon Begley byline, almost 5 years after her death.

Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."

Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 8, 2025 at 1:39 PM
Reposted by Ian Sealy
Anyway, we need some joy, so here's the Egyptian foreign minister being given a Lego Pyramid by the Danish foreign minister.
November 3, 2025 at 2:35 PM
g:Profiler released a new version a couple of weeks ago that uses data from Ensembl 113, so I've updated a few of the plots. It doesn't actually change anything though and we still await Ensembl 115 eagerly! See github.com/iansealy/ens... for all the details.
Ensembl have confirmed that the human gene name issue will be fixed in Ensembl 115. Yay!
I've updated this for the recently released Ensembl 114. Things are looking better - there are more genes than ever before annotated to ZFIN IDs, which is great. But there seems to be a major problem still.
June 30, 2025 at 11:00 AM
Reposted by Ian Sealy
For anyone who doesn't want to miss their favourite Glastonbury act on iPlayer, I made a quick-and-dirty Firebase app that allows you to select the acts you want to watch from the schedule then download them as an iCal file.

studio--glasto-planner-g2nbd.us-central1.hosted.app
Glasto Planner
Plan your Glastonbury 2025 schedule
studio--glasto-planner-g2nbd.us-central1.hosted.app
June 27, 2025 at 3:52 PM
Ensembl have confirmed that the human gene name issue will be fixed in Ensembl 115. Yay!
I've updated this for the recently released Ensembl 114. Things are looking better - there are more genes than ever before annotated to ZFIN IDs, which is great. But there seems to be a major problem still.
Someone on Mastodon recently posted about issues they've seen with #zebrafish annotation in recent #Ensembl versions, so I wrote down some of what I've noticed.

I'll summarise here, but the TL;DR version is that we are just using Ensembl 109's annotation, including for enrichment analyses.
May 19, 2025 at 3:46 PM
I've updated this for the recently released Ensembl 114. Things are looking better - there are more genes than ever before annotated to ZFIN IDs, which is great. But there seems to be a major problem still.
Someone on Mastodon recently posted about issues they've seen with #zebrafish annotation in recent #Ensembl versions, so I wrote down some of what I've noticed.

I'll summarise here, but the TL;DR version is that we are just using Ensembl 109's annotation, including for enrichment analyses.
GitHub - iansealy/ens-zf-annotation-issue: Ensembl zebrafish annotation issues
Ensembl zebrafish annotation issues. Contribute to iansealy/ens-zf-annotation-issue development by creating an account on GitHub.
github.com
May 17, 2025 at 9:02 PM
Reposted by Ian Sealy
GRCz12tu is available on Genbank. This will be one of two genomes that will be considered "reference" genomes, there will also be a GRCz12ab assembly coming. It has entered the NCBI annotation pipeline and will also go into the Ensembl annotation pipeline.
www.ncbi.nlm.nih.gov/datasets/gen...
Danio rerio genome assembly GRCz12tu
- Danio rerio
www.ncbi.nlm.nih.gov
April 8, 2025 at 9:44 PM
Post a movie from the year you turned 18

I think I might have been the only person in the cinema who hadn't seen the trailer and didn't know there was a twist coming.
April 10, 2025 at 7:26 AM
Reposted by Ian Sealy
RealityF1 returns for the 2025 season. The new season is now live and you can sign in and create your team at: realityf1.com
March 12, 2025 at 6:40 PM
Wish I'd known about www.openhistoricalmap.org when I was reading Jonn Elledge's "A History of the World in 47 Borders" recently. (Recommended.)
TIL about the existence of OpenHistoricalMap, an open collaborative project where people can contribute features to a world map over history (currently from 1825 onwards).
March 4, 2025 at 10:41 PM
Reposted by Ian Sealy
I had a great time on @ebi.embl.org ‘s RNAseq course last week.

Would highly recommend it to anyone looking at working with RNAseq data in the future 🧬
It's been great to get our 2025 courses underway over the last few weeks! We've already run two virtual courses, with attendees learning more about #RNAseq and use of #Python for data analysis.

Want to join us in 2026? Take a look at our courses: www.ebi.ac.uk/training/liv...

🧪🧬🖥️ #GeneSky
March 4, 2025 at 9:45 AM
Reposted by Ian Sealy
It's been great to get our 2025 courses underway over the last few weeks! We've already run two virtual courses, with attendees learning more about #RNAseq and use of #Python for data analysis.

Want to join us in 2026? Take a look at our courses: www.ebi.ac.uk/training/liv...

🧪🧬🖥️ #GeneSky
March 4, 2025 at 9:36 AM
Reposted by Ian Sealy
@lionelhenry.bsky.social and I are so excited to finally announce Air - an extremely fast R code formatter! 🎉

With Air, you'll never need to worry about styling your #rstats code ever again. All you need to do is save, and Air takes care of the rest.

www.tidyverse.org/blog/2025/02...
Air, an extremely fast R formatter
We are thrilled to announce Air, a new R formatter.
www.tidyverse.org
February 21, 2025 at 3:10 PM
Slight update to this, as g:Profiler have updated to use Ensembl 112 data. The advice stays the same though - we're using Ensembl 109 for #zebrafish analysis. See: github.com/iansealy/ens...
Someone on Mastodon recently posted about issues they've seen with #zebrafish annotation in recent #Ensembl versions, so I wrote down some of what I've noticed.

I'll summarise here, but the TL;DR version is that we are just using Ensembl 109's annotation, including for enrichment analyses.
GitHub - iansealy/ens-zf-annotation-issue: Ensembl zebrafish annotation issues
Ensembl zebrafish annotation issues. Contribute to iansealy/ens-zf-annotation-issue development by creating an account on GitHub.
github.com
February 4, 2025 at 6:03 PM
Someone on Mastodon recently posted about issues they've seen with #zebrafish annotation in recent #Ensembl versions, so I wrote down some of what I've noticed.

I'll summarise here, but the TL;DR version is that we are just using Ensembl 109's annotation, including for enrichment analyses.
GitHub - iansealy/ens-zf-annotation-issue: Ensembl zebrafish annotation issues
Ensembl zebrafish annotation issues. Contribute to iansealy/ens-zf-annotation-issue development by creating an account on GitHub.
github.com
January 21, 2025 at 10:41 PM
@ruthmichaelson.com Lovely to see you both today. By the way, this is the .io thing I mentioned as we were leaving: every.to/p/the-disapp...
The Disappearance of an Internet Domain
How geopolitics can alter digital infrastructure
every.to
December 22, 2024 at 8:26 PM
I had no idea this even existed. There's more info at www.theguardian.com/culture/2018.... Plus en.m.wikipedia.org/wiki/English... lists other versions.
December 9, 2024 at 8:05 PM