Vidhyadhar Nandana
@iamvidyadhar.bsky.social
Interests and expertise are in biochemistry and biophysics of RNPs and Biomolecular condensates in eukaryotic and bacterial gene regulation processes
Reposted by Vidhyadhar Nandana
Our team found the N-terminal IDR of bacterial translation initiation factor 2 promotes condensation with RNA that is stimulated in the cold. We think these cold-stimulated IF2 condensates likely explain why the IDR's deletion in E. coli is unable to grow in the cold. www.biorxiv.org/content/10.1...
Bacterial IF2’s N-terminal IDR drives cold-induced phase separation and promotes fitness during cold stress
Translation initiation factor 2 (IF2) plays an essential role in bacterial cells by delivering the fMet-tRNAfMet to the ribosome pre-initiation complex. IF2 is known to have an N-terminal disordered r...
www.biorxiv.org
February 13, 2025 at 2:42 PM
Our team found the N-terminal IDR of bacterial translation initiation factor 2 promotes condensation with RNA that is stimulated in the cold. We think these cold-stimulated IF2 condensates likely explain why the IDR's deletion in E. coli is unable to grow in the cold. www.biorxiv.org/content/10.1...