Huocong Huang
@huoconghuang.bsky.social
Huang Lab, UT Southwestern Medical Center. Studying fibroblast in cancer, wound and aging.
Happy to share our latest work in collaboration with Sihan Wu and James Chen labs. We found ecDNA is not only a vehicle, but can drive oncogene super expressors that induce a unique stromal niche by AREG secretion. This rapidly leads to myCAF expansion and T cell exclusion.
ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment https://www.biorxiv.org/content/10.1101/2025.11.15.688565v1
November 17, 2025 at 2:48 PM
Happy to share our latest work in collaboration with Sihan Wu and James Chen labs. We found ecDNA is not only a vehicle, but can drive oncogene super expressors that induce a unique stromal niche by AREG secretion. This rapidly leads to myCAF expansion and T cell exclusion.
Our paper online now, CAF molecular phenotypes are more conserved than we thought across organs. Plus we now know more details about apCAFs. Please check it out 👉 Cancer Cell www.cell.com/cancer-cell/...
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches
Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast
(apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate
near cancer cells while fibrocyte-...
www.cell.com
September 25, 2025 at 4:07 PM
Our paper online now, CAF molecular phenotypes are more conserved than we thought across organs. Plus we now know more details about apCAFs. Please check it out 👉 Cancer Cell www.cell.com/cancer-cell/...
Reposted by Huocong Huang
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 10, 2025 at 5:49 PM
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Reposted by Huocong Huang
Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...
Stromal KITL/SCF maintains pancreas tissue homeostasis and restrains tumor progression
Abstract. Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to...
aacrjournals.org
February 7, 2025 at 2:14 PM
Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...
Reposted by Huocong Huang
🚨 2024 is coming to a close but #research on #fibroblast #functions in #cancer it’s far from done ✅.
If you want to know more, have a read at our latest #review now in press @trendscancer. 👇🏼👇🏼
Fantastic job by Priscilla and Marta 🌟👏🏻.
And happy 2025 to all 🫶
www.sciencedirect.com/science/arti...
If you want to know more, have a read at our latest #review now in press @trendscancer. 👇🏼👇🏼
Fantastic job by Priscilla and Marta 🌟👏🏻.
And happy 2025 to all 🫶
www.sciencedirect.com/science/arti...
Functional heterogeneity of fibroblasts in primary tumors and metastases
Cancer-associated fibroblasts (CAFs) are abundant components of the tumor microenvironment (TME) of most solid malignancies and have emerged as key re…
www.sciencedirect.com
December 16, 2024 at 7:47 AM
🚨 2024 is coming to a close but #research on #fibroblast #functions in #cancer it’s far from done ✅.
If you want to know more, have a read at our latest #review now in press @trendscancer. 👇🏼👇🏼
Fantastic job by Priscilla and Marta 🌟👏🏻.
And happy 2025 to all 🫶
www.sciencedirect.com/science/arti...
If you want to know more, have a read at our latest #review now in press @trendscancer. 👇🏼👇🏼
Fantastic job by Priscilla and Marta 🌟👏🏻.
And happy 2025 to all 🫶
www.sciencedirect.com/science/arti...
Reposted by Huocong Huang
Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation
KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.
www.science.org
November 29, 2024 at 7:30 PM
Reposted by Huocong Huang
Multiple NCI-PSRC investigators co-authored this perspective in Cancer Research last month:
#PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here?
aacrjournals.org/cancerres/ar...
@kenolivelab.bsky.social
@marasherman.bsky.social
@debvendramini.bsky.social
@tme-caf-ecm.bsky.social
#PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here?
aacrjournals.org/cancerres/ar...
@kenolivelab.bsky.social
@marasherman.bsky.social
@debvendramini.bsky.social
@tme-caf-ecm.bsky.social
aacrjournals.org
November 28, 2024 at 10:19 PM
Multiple NCI-PSRC investigators co-authored this perspective in Cancer Research last month:
#PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here?
aacrjournals.org/cancerres/ar...
@kenolivelab.bsky.social
@marasherman.bsky.social
@debvendramini.bsky.social
@tme-caf-ecm.bsky.social
#PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here?
aacrjournals.org/cancerres/ar...
@kenolivelab.bsky.social
@marasherman.bsky.social
@debvendramini.bsky.social
@tme-caf-ecm.bsky.social
Reposted by Huocong Huang
#PancreaticCancer research starter pack.
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
November 23, 2024 at 9:52 PM
#PancreaticCancer research starter pack.
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW
Reposted by Huocong Huang
Thank you @gabriellebrewer.bsky.social for highlighting our work in Nature Reviews Cancer, led by grad student @justeng95.bsky.social.
Check out the original paper in Cell here:
www.cell.com/cell/fulltex...
Here's a summary thread from "the other site": x.com/PeterLyLab/s...
Check out the original paper in Cell here:
www.cell.com/cell/fulltex...
Here's a summary thread from "the other site": x.com/PeterLyLab/s...
November 21, 2024 at 4:23 PM
Thank you @gabriellebrewer.bsky.social for highlighting our work in Nature Reviews Cancer, led by grad student @justeng95.bsky.social.
Check out the original paper in Cell here:
www.cell.com/cell/fulltex...
Here's a summary thread from "the other site": x.com/PeterLyLab/s...
Check out the original paper in Cell here:
www.cell.com/cell/fulltex...
Here's a summary thread from "the other site": x.com/PeterLyLab/s...
Reposted by Huocong Huang
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches https://www.biorxiv.org/content/10.1101/2024.11.15.623232v1
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches https://www.biorxiv.org/content/10.1101/2024.11.15.623232v1
Recent studies have identified a unique subtype of cancer-associated fibroblasts (CAFs) termed antig
www.biorxiv.org
November 18, 2024 at 2:48 AM
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches https://www.biorxiv.org/content/10.1101/2024.11.15.623232v1
Thanks Deb! Happy to share our work on pan-cancer analysis of apCAF at an unprecedented resolution. Through this study we have a much better idea about this CAF subtype!
It’s great to see this pre-print from the @huoconghuang.bsky.social! Must read for people interested in apCafs!
Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches #SingleCell biorxiv.org/cgi/content/...
November 18, 2024 at 5:21 PM
Thanks Deb! Happy to share our work on pan-cancer analysis of apCAF at an unprecedented resolution. Through this study we have a much better idea about this CAF subtype!