In case you needed a reminder that Strep pneumo urinary antigen has poor sensitivity. Let’s stop ordering tests that won’t change our management plan #TWDFNR #IDSKY

Step 3: antibiotic!

Using meropenem-vaborbactam for this KPC-3 Enterobacter cloacae. Started with a loading dose over 30 minutes, then doing 3-hour extended infusions every 8 hours with the syringe pump.

Yes - I feel overwhelmed in large crowds. The inoculum effect applies directly to me 😂

Step 2: set up the SEV model

This ex vivo model is a controlled environment that represents infective endocarditis within the central compartment (where those vegetations with E. cloacae are hanging out)

#IDSky #MedSky

Learning about SEV (simulated endocardial vegetation) models! ID pharmacy residents at UK can spend a month in the PK/PD lab at the college and learn how to do bench top studies.

Step 1: make the clot, then inoculate it with organism (working with Enterobacter cloacae with KPC-3)

#IDSky #MedSky