Tim Humphrey
humphreylab.bsky.social
Tim Humphrey
@humphreylab.bsky.social
Chromosome Integrity Group, Genome Damage and Stability Centre, University of Sussex.
Reposted by Tim Humphrey
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!

Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae
Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor
academic.oup.com
November 13, 2025 at 8:40 PM
Tonight was the U.K. premier of ‘Goodbye Breasts’ written, directed and produced by Joanne Callaghan, documenting her remarkable breast cancer story. A must see!
@gdsc-sussex.bsky.social
@sussexcancer.org
@sussexbcr.bsky.social
sussexcancerfund.co.uk
November 11, 2025 at 10:33 PM
Delighted to wave the flag for @gdsc-sussex.bsky.social
@sussexcancer.org
@sussexbcr.bsky.social
sussexcancerfund.co.uk together with Rhys Morgan at the Science Cafe, MacMillan Horizon centre today. Thanks to Rebecca Herbertson and Stephen Robinson for organizing.
@rhysmorganlab.bsky.social
September 29, 2025 at 8:26 PM
Reposted by Tim Humphrey
🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.
Research Technician – Protein Biochemistry at University of Sussex
Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
September 9, 2025 at 8:35 AM
Reposted by Tim Humphrey
So pleased to see my PhD project published, great work by everyone involved! Together we uncovered how regulation of the BTRR complex is crucial to protect centromeres during mitosis.
September 1, 2025 at 6:58 AM
Reposted by Tim Humphrey
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.

doi.org/10.1038/s415...
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
doi.org
September 3, 2025 at 3:13 PM
Reposted by Tim Humphrey
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 3:59 PM
Reposted by Tim Humphrey
🧬 The 2025 Emma Whitelaw ECR publication award is now open!

Full T&Cs and application form are on the AEpiA website www.aepia.org.au/emma-whitela...

We can't wait to see the exciting research that has been published over the last year!

#epigenetics #ECR #research #AEpiA
Emma Whitelaw Publication Award — Australasian Epigenetics Alliance
www.aepia.org.au
August 25, 2025 at 2:35 AM
Reposted by Tim Humphrey
Prof. Evi Soutoglou describing what happens when DNA breaks, and when to cut, and when not to — on Brighton seafront, as part of Soapbox Science 2025 — a public outreach platform that promote women and non-binary scientists and the science that they carry out. ‪@soapboxscience.bsky.social‬
June 23, 2025 at 10:38 AM
Reposted by Tim Humphrey
Dr. Luke Yates, along with Prof. Zhang and Prof. Burgers, summarise our current mechanistic understanding of the DNA damage checkpoint; inc. structural studies of ATM and ATR and how these work together to prevent cancer.
doi.org/10.1146/annu...
@layates.bsky.social @crick.ac.uk @washu.bsky.social
DNA Damage and Replication Stress Checkpoints | Annual Reviews
DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to eli...
doi.org
June 24, 2025 at 8:41 AM
Reposted by Tim Humphrey
Exciting to see SCRC Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield, highlighted on BBC news.
"Words from the Waiting Room offers cancer patients, survivors, and supporters a safe environment to express themselves"
sussexcancer.org/news/bbc-new...
BBC News, South East covers Words from the Waiting Room. — Sussex Cancer Research Centre
Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield highlighted on BBC news. Words from the Waiting Room offers cancer patients, survivors, and supporters a safe enviro...
sussexcancer.org
March 25, 2025 at 11:12 AM
Congratulations to Dr Stephen Robinson for launching the Sussex Brain Tumour Research Group.
@sussexcancer.bsky.social
March 11, 2025 at 6:53 PM
Reposted by Tim Humphrey
Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal
imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ...
www.embopress.org
January 3, 2025 at 9:30 AM
Reposted by Tim Humphrey
Today we celebrate our inspirational co-director Professor Melanie Flint m as she gives her inaugural lecture @brightonuni.bsky.social
An incredible scientist, leader, mentor, and all around amazing person.
December 4, 2024 at 8:21 PM
Reposted by Tim Humphrey
Co-directors @humphreylab.bsky.social and @siftw.bsky.social were at Parliament today, celebrating 20 years of Brighton and Sussex Medical School, and working to make sure cancer research is at the centre of the next 20 years. @sussexuni.bsky.social @brightonuni.bsky.social
November 21, 2024 at 12:18 AM
Great to join you here today and looking forward to some blue sky science chat!
November 14, 2024 at 10:08 AM