High-throughput sequencing and artificial intelligence-driven structural biology have vastly expanded our understanding of the human metagenome, yet microbial functions remain largely elusive. In this...

Microorganisms can inhabit diverse environments, including the human gut [1]. Gut bacteria can continuously evolve in response to changes in the intestinal

This study explores the dynamics of mobile genetic elements in the infant gut after cesarean birth. Fernández-Pato et al. show that early infant gut mobilome is highly individual-specific and shaped by feeding mode. Antibiotic exposure at birth has minimal effect, and early mother–infant strain-sharing is rarely detected.

ChronoStrain accurately profiles low-abundance strains in longitudinal samples by jointly modelling nucleotide sequencing errors, strain presence/absence and the temporal information associated with e...