House of Byrne Lab
@hob-lab.bsky.social
Research lab of @drl-bo.bsky.social based @ucl-hd.bsky.social @uclqsion.bsky.social working on adult and Juvenile-onset Huntington's Disease biomarkers.
We replicated the consistency between NfL concentrations in venous and capillary blood samples in a confirmatory cohort (recruited from the HD-Young Adult Study). We also replicated NfL’s disease group differences and CAG dependent relationship witg age.
July 10, 2025 at 4:42 PM
We replicated the consistency between NfL concentrations in venous and capillary blood samples in a confirmatory cohort (recruited from the HD-Young Adult Study). We also replicated NfL’s disease group differences and CAG dependent relationship witg age.
Capillary NfL showed the same clinical disease group differences as venous NfL in the multi‑disease discovery cohort.
N.B. We were not powered for these group comparisons but did this to illustrate that the pattern is the same as the gold standard
N.B. We were not powered for these group comparisons but did this to illustrate that the pattern is the same as the gold standard
July 10, 2025 at 4:42 PM
Capillary NfL showed the same clinical disease group differences as venous NfL in the multi‑disease discovery cohort.
N.B. We were not powered for these group comparisons but did this to illustrate that the pattern is the same as the gold standard
N.B. We were not powered for these group comparisons but did this to illustrate that the pattern is the same as the gold standard
Only NfL showed high stability after seven‑day delayed processing in venous and capillary serum and plasma in the multi‑disease discovery cohort despite a huge amount of haemolysis evident in the samples. GFAP was still correlated but clearly started to go down after 7 days delay.
July 10, 2025 at 4:42 PM
Only NfL showed high stability after seven‑day delayed processing in venous and capillary serum and plasma in the multi‑disease discovery cohort despite a huge amount of haemolysis evident in the samples. GFAP was still correlated but clearly started to go down after 7 days delay.
NfL and GFAP showed high stability after three‑day delayed processing in venous and capillary serum and plasma in the multi‑disease discovery cohort. Again data falls on y=x
Total protein and haemoglobin were included to the impact of delayed process on the average protein.
Total protein and haemoglobin were included to the impact of delayed process on the average protein.
July 10, 2025 at 4:42 PM
NfL and GFAP showed high stability after three‑day delayed processing in venous and capillary serum and plasma in the multi‑disease discovery cohort. Again data falls on y=x
Total protein and haemoglobin were included to the impact of delayed process on the average protein.
Total protein and haemoglobin were included to the impact of delayed process on the average protein.
NfL and GFAP concentrations were highly correlated in venous and capillary serum and plasma in a multi‑disease discovery cohort including MS, ALS, HD, and PD participants. Notice how values lie along the y=x line of equality!
July 10, 2025 at 4:42 PM
NfL and GFAP concentrations were highly correlated in venous and capillary serum and plasma in a multi‑disease discovery cohort including MS, ALS, HD, and PD participants. Notice how values lie along the y=x line of equality!
We first adapted a finger‑prick collection approach for NfL quantification and set up several experiments to assess whether it was the same as the gold standard venepuncture, and whether delayed sample processing would impact NfL values. We tested other potential biomarkers GFAP and Total Tau
July 10, 2025 at 4:42 PM
We first adapted a finger‑prick collection approach for NfL quantification and set up several experiments to assess whether it was the same as the gold standard venepuncture, and whether delayed sample processing would impact NfL values. We tested other potential biomarkers GFAP and Total Tau