Hyun Kyu Song
@hksong.bsky.social
A structural biologist for understanding protein degradation mechanism
Reposted by Hyun Kyu Song
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles
Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase,
which is activated through nucleic-acid-induced oligomerization and is critical for
cell survival during immune ...
www.cell.com
August 27, 2025 at 7:04 PM
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Hyun Kyu Song
Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
August 28, 2025 at 6:54 PM
Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
Reposted by Hyun Kyu Song
Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
nature.com/articles/s41...
#plantscience
nature.com/articles/s41...
#plantscience
August 23, 2025 at 5:13 PM
Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin
nature.com/articles/s41...
#plantscience
nature.com/articles/s41...
#plantscience
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control | Science www.science.org/doi/10.1126/...
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
Eukaryotic cells have evolved sophisticated quality control mechanisms to eliminate aggregation-prone proteins that compromise cellular health. Central to this defense is the ubiquitin-proteasome syst...
www.science.org
August 28, 2025 at 11:57 PM
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control | Science www.science.org/doi/10.1126/...