HITh lab InsermU1176
@hithlabinserm1176.bsky.social
Thrilled to share our latest work in @natcomms.nature.com !
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
Excited to share that our paper is out in @natcomms.nature.com
🔗 rdcu.be/ez3Gt
We uncover how MICAL1 regulates actin dynamics to enhance VWF–GPIbα binding in platelets.
Big thanks to all co-authors & collaborators !
@hithlabinserm1176.bsky.social @echardlab-pasteur.bsky.social
🔗 rdcu.be/ez3Gt
We uncover how MICAL1 regulates actin dynamics to enhance VWF–GPIbα binding in platelets.
Big thanks to all co-authors & collaborators !
@hithlabinserm1176.bsky.social @echardlab-pasteur.bsky.social
F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets
Nature Communications - To stop bleeding from an injured vessel, platelets adhere and form a clot despite high shear stress from the flow. Here, the authors show that platelet actin disassembly is...
rdcu.be
August 12, 2025 at 10:02 AM
Thrilled to share our latest work in @natcomms.nature.com !
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
The @hithlabinserm1176.bsky.social is proud to support #ISTHEarlyCareer by leading educational sessions at #ISTH2025!
June 21, 2025 at 11:05 AM
The @hithlabinserm1176.bsky.social is proud to support #ISTHEarlyCareer by leading educational sessions at #ISTH2025!
Reposted by HITh lab InsermU1176
💡Honoring the impact & memory of the late Claire McLintock, this @ISTH.org grant supports #ISTHEarlyCareer innovative research in women's health issues in #thrombosis & #hemostasis.
Learn more ⬇️and apply by ⏳ Sept. 1!
t.co/QYL9cUcoav
Thank you to all donors who supported this grant!
#ISTH2025
Learn more ⬇️and apply by ⏳ Sept. 1!
t.co/QYL9cUcoav
Thank you to all donors who supported this grant!
#ISTH2025
June 20, 2025 at 2:30 PM
💡Honoring the impact & memory of the late Claire McLintock, this @ISTH.org grant supports #ISTHEarlyCareer innovative research in women's health issues in #thrombosis & #hemostasis.
Learn more ⬇️and apply by ⏳ Sept. 1!
t.co/QYL9cUcoav
Thank you to all donors who supported this grant!
#ISTH2025
Learn more ⬇️and apply by ⏳ Sept. 1!
t.co/QYL9cUcoav
Thank you to all donors who supported this grant!
#ISTH2025
The @hithlabinserm1176.bsky.social is ready for #ISTH2025!
June 21, 2025 at 11:01 AM
The @hithlabinserm1176.bsky.social is ready for #ISTH2025!
Reposted by HITh lab InsermU1176
🌟 #ECTH2025 is just around the corner! 🌟
Join us in Prague to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture.
🔗 Register here to secure early bird rates: www.ecth.org/registration/
Curious about CzechFunFact #2?
#ECTH2025 #ECTHJAB #CzechFunFacts
Join us in Prague to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture.
🔗 Register here to secure early bird rates: www.ecth.org/registration/
Curious about CzechFunFact #2?
#ECTH2025 #ECTHJAB #CzechFunFacts
June 11, 2025 at 10:25 PM
🌟 #ECTH2025 is just around the corner! 🌟
Join us in Prague to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture.
🔗 Register here to secure early bird rates: www.ecth.org/registration/
Curious about CzechFunFact #2?
#ECTH2025 #ECTHJAB #CzechFunFacts
Join us in Prague to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture.
🔗 Register here to secure early bird rates: www.ecth.org/registration/
Curious about CzechFunFact #2?
#ECTH2025 #ECTHJAB #CzechFunFacts
Reposted by HITh lab InsermU1176
A special day: Jean Solarz, my first PhD student, successfully defended his thesis. Proud of all the work accomplished! Thks to jury members.
Huge congratulations to Dr Jean Solarz for brilliantly defending his PhD today! And to his supervisors @alexkzis.bsky.social and Frederic Adam.
We are very proud of you!
A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe
We are very proud of you!
A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe
June 5, 2025 at 7:46 PM
A special day: Jean Solarz, my first PhD student, successfully defended his thesis. Proud of all the work accomplished! Thks to jury members.
Huge congratulations to Dr Jean Solarz for brilliantly defending his PhD today! And to his supervisors @alexkzis.bsky.social and Frederic Adam.
We are very proud of you!
A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe
We are very proud of you!
A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe
June 5, 2025 at 7:37 PM
Huge congratulations to Dr Jean Solarz for brilliantly defending his PhD today! And to his supervisors @alexkzis.bsky.social and Frederic Adam.
We are very proud of you!
A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe
We are very proud of you!
A big thank you to all the committee members Prof N Ajzenberg, Dr MP Gratacap, Dr G Romet-Lemonne, Dr Leon, and Dr Ho-Tin-Noe
Reposted by HITh lab InsermU1176
#ECTH2025 is just around the corner!
Join us to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture and steeped in history!
🔗 Register here to secure early bird rates: www.ecth.org/registration/
#ECTH2025 #ECTHJAB #CzechFunFacts
Join us to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture and steeped in history!
🔗 Register here to secure early bird rates: www.ecth.org/registration/
#ECTH2025 #ECTHJAB #CzechFunFacts
May 28, 2025 at 5:45 PM
#ECTH2025 is just around the corner!
Join us to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture and steeped in history!
🔗 Register here to secure early bird rates: www.ecth.org/registration/
#ECTH2025 #ECTHJAB #CzechFunFacts
Join us to explore the latest discoveries in #thrombosisandhaemostasis in a beautiful place rich in culture and steeped in history!
🔗 Register here to secure early bird rates: www.ecth.org/registration/
#ECTH2025 #ECTHJAB #CzechFunFacts
Reposted by HITh lab InsermU1176
#ECTH2025 outstanding lineup of speakers - leaders, innovators, experts in #thrombosis & #haemostasis #ECTH @sophiesusen.bsky.social @cjbinder.bsky.social @cedrichermans.bsky.social
May 6, 2025 at 7:27 PM
#ECTH2025 outstanding lineup of speakers - leaders, innovators, experts in #thrombosis & #haemostasis #ECTH @sophiesusen.bsky.social @cjbinder.bsky.social @cedrichermans.bsky.social
The lab was present at #WFHCCS2025 in Dubai!
#VWF #VWD #science #WFH
@hithlabinserm1176.bsky.social @caterinacasari.bsky.social
#VWF #VWD #science #WFH
@hithlabinserm1176.bsky.social @caterinacasari.bsky.social
It has been a honor to speak at the #WFHccs2025 in Dubai and share the stage with Drs Michelle Lavin and Augusto Federici!
Thanks #WFH for this opportunity!
Thanks #WFH for this opportunity!
May 2, 2025 at 9:38 AM
The lab was present at #WFHCCS2025 in Dubai!
#VWF #VWD #science #WFH
@hithlabinserm1176.bsky.social @caterinacasari.bsky.social
#VWF #VWD #science #WFH
@hithlabinserm1176.bsky.social @caterinacasari.bsky.social
Happy to share our latest work!
Early view on Haematologica Journal
➡️ haematologica.org/article/view...
#nonfactortherapies #FVIII #hemophiliaA #thrombosisandhaemostasis
Early view on Haematologica Journal
➡️ haematologica.org/article/view...
#nonfactortherapies #FVIII #hemophiliaA #thrombosisandhaemostasis
Early View
| Haematologica
haematologica.org
April 5, 2025 at 10:02 AM
Happy to share our latest work!
Early view on Haematologica Journal
➡️ haematologica.org/article/view...
#nonfactortherapies #FVIII #hemophiliaA #thrombosisandhaemostasis
Early view on Haematologica Journal
➡️ haematologica.org/article/view...
#nonfactortherapies #FVIII #hemophiliaA #thrombosisandhaemostasis
Important paper from the ISTH SSC Platelet Physiology group! Congrats @alexkzis.bsky.social @dianvanderwaldr.bsky.social and all the authors!
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
We have worked for 2 years with @dianvanderwaldr.bsky.social to propose a protocol for platelet desialylation, and we are excited to now share it. Communication from the ISTH SSC Platelet Physiology. - Journal of Thrombosis and Haemostasis www.jthjournal.org/article/S153... #hemsky #hemesky
Consensus protocol for platelet desialylation (β-galactose exposure) quantification using lectins by flow cytometry: Communication from the ISTH SSC Subcommittee on Platelet Physiology.
Platelets contain many heterogeneous carbohydrates (glycans): often capped by sialic
acid. The removal of sialic acid (desialylation) is important for platelet function
and clearance, leading to novel...
www.jthjournal.org
April 4, 2025 at 4:16 PM
Important paper from the ISTH SSC Platelet Physiology group! Congrats @alexkzis.bsky.social @dianvanderwaldr.bsky.social and all the authors!
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
@isth.org @jthjournal.bsky.social
#platelets #thrombosisandhaemostasis
New day, new presentation at #SFH2025
Congrats Jean Solarz-PhD student in our group- for his great presentation!
#platelets #thrombosisandhaemostasis
Congrats Jean Solarz-PhD student in our group- for his great presentation!
#platelets #thrombosisandhaemostasis
Bravo Jean Solarz for your presentation at the French Society of Hematology on MICAL1 @hithlabinserm1176.bsky.social #sfh #Hemsky #hemesky
April 4, 2025 at 4:11 PM
New day, new presentation at #SFH2025
Congrats Jean Solarz-PhD student in our group- for his great presentation!
#platelets #thrombosisandhaemostasis
Congrats Jean Solarz-PhD student in our group- for his great presentation!
#platelets #thrombosisandhaemostasis
Congratulations Toscane Viellard -PhD in our group- for her excellent presentation at #SFH2025
#platelets #thrombosisandhaemostasis
#platelets #thrombosisandhaemostasis
April 4, 2025 at 4:08 PM
Congratulations Toscane Viellard -PhD in our group- for her excellent presentation at #SFH2025
#platelets #thrombosisandhaemostasis
#platelets #thrombosisandhaemostasis
Reposted by HITh lab InsermU1176
If you missed our paper on the humanized murine model of VWD-type 1 (hVWD1) you can read it haematologica.org/article/view...
The model provides a novel platform to test therapeutic options for #VWD one of which is explored in the paper! Thanks Haematologica for the highlight as Editor’s pick!
The model provides a novel platform to test therapeutic options for #VWD one of which is explored in the paper! Thanks Haematologica for the highlight as Editor’s pick!
A fully humanized von Willebrand disease type 1 mouse model as unique platform to investigate novel therapeutic options
| Haematologica
haematologica.org
April 1, 2025 at 9:36 PM
If you missed our paper on the humanized murine model of VWD-type 1 (hVWD1) you can read it haematologica.org/article/view...
The model provides a novel platform to test therapeutic options for #VWD one of which is explored in the paper! Thanks Haematologica for the highlight as Editor’s pick!
The model provides a novel platform to test therapeutic options for #VWD one of which is explored in the paper! Thanks Haematologica for the highlight as Editor’s pick!
🎉Huge congratulations to Dr Claire Auditeau 🎓 for brilliantly defending her PhD today! And to her supervisors Pr Delphine Borgel and Dr Francois Saller!
A big thank you to all the committee members Pr Angelillo-Scherrer, Pr Garçon, Dr Allali, Pr Frere!
Happy and proud of your achievement!
A big thank you to all the committee members Pr Angelillo-Scherrer, Pr Garçon, Dr Allali, Pr Frere!
Happy and proud of your achievement!
March 27, 2025 at 6:07 PM
🎉Huge congratulations to Dr Claire Auditeau 🎓 for brilliantly defending her PhD today! And to her supervisors Pr Delphine Borgel and Dr Francois Saller!
A big thank you to all the committee members Pr Angelillo-Scherrer, Pr Garçon, Dr Allali, Pr Frere!
Happy and proud of your achievement!
A big thank you to all the committee members Pr Angelillo-Scherrer, Pr Garçon, Dr Allali, Pr Frere!
Happy and proud of your achievement!
Happy to share our latest collaborative work on the characterization of the Afro-Caribbean #VWD cohort in Martinique island! Congrats Dr Marie-Daniela Dubois and all the authors!
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Clinical, Phenotypic and Genotypic Characteristics of Von Willebrand Disease in Afro‐Caribbeans: Results From a Study in Martinique Island, French West Indies
Background Several cohort studies have investigated the molecular basis of von Willebrand disease (VWD); very few have focused on the Afro-Caribbean population. Objectives To determine the genotyp...
onlinelibrary.wiley.com
March 27, 2025 at 5:57 PM
Happy to share our latest collaborative work on the characterization of the Afro-Caribbean #VWD cohort in Martinique island! Congrats Dr Marie-Daniela Dubois and all the authors!
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Our lab is glad to collaborate with both teams! 🥳
Great collaboration with Hana Raslova and @alessandrabalduini.bsky.social teams on BSS signaling defect! Recently published. @hithlabinserm1176.bsky.social
haematologica.org/article/view...
haematologica.org/article/view...
Early View
| Haematologica
haematologica.org
March 21, 2025 at 3:19 AM
Our lab is glad to collaborate with both teams! 🥳
Reposted by HITh lab InsermU1176
The JAB is working hard alongside the @ECTH Board to shape a congress that truly supports and empowers #EarlyCareer scientists!
You can already submit your abstract for #ECTH2025 here: www.ecth.org/abstracts/
You can already submit your abstract for #ECTH2025 here: www.ecth.org/abstracts/
March 6, 2025 at 4:11 PM
The JAB is working hard alongside the @ECTH Board to shape a congress that truly supports and empowers #EarlyCareer scientists!
You can already submit your abstract for #ECTH2025 here: www.ecth.org/abstracts/
You can already submit your abstract for #ECTH2025 here: www.ecth.org/abstracts/
Congratulations to our colleague @Dr Jildaz Caroff for successfully obtaining his HDR (Habilitation à diriger des recherches)!! 👏🏻👏🏻👏🏻👏🏻
March 5, 2025 at 12:30 PM
Congratulations to our colleague @Dr Jildaz Caroff for successfully obtaining his HDR (Habilitation à diriger des recherches)!! 👏🏻👏🏻👏🏻👏🏻
In the @hithlabinserm1176.bsky.social we love to collaborate! Check out this very interesting paper by @Prof Elisa Rossi with valuable contributions by @alexkzis.bsky.social and @ceciledenis.bsky.social from our group!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia - Communications Biology
Thrombin cleaves membrane-bound endoglin and soluble endoglin, releasing fragments of varying sizes; these findings emphasize the heterogeneity of sEng in preeclampsia, connecting endothelial dysfunct...
www.nature.com
March 3, 2025 at 11:47 PM
In the @hithlabinserm1176.bsky.social we love to collaborate! Check out this very interesting paper by @Prof Elisa Rossi with valuable contributions by @alexkzis.bsky.social and @ceciledenis.bsky.social from our group!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
👏An incredible session by 3 incredible women during the #gth2025 with Alessandra Balduini on Red blood cells prod, Catherine Strassel on platelet prod and Caterina Casari with bioinspired platelets. @alessandrabalduini.bsky.social @caterinacasari.bsky.social
February 21, 2025 at 11:47 AM
👏An incredible session by 3 incredible women during the #gth2025 with Alessandra Balduini on Red blood cells prod, Catherine Strassel on platelet prod and Caterina Casari with bioinspired platelets. @alessandrabalduini.bsky.social @caterinacasari.bsky.social
Great presention of Caterina Casari during the #GTH2025 on SynthoPlates. When art meets science. 🇨🇭 @caterinacasari.bsky.social #womeninscience #synthoplates
February 21, 2025 at 11:42 AM
Great presention of Caterina Casari during the #GTH2025 on SynthoPlates. When art meets science. 🇨🇭 @caterinacasari.bsky.social #womeninscience #synthoplates
Reposted by HITh lab InsermU1176
The lab is at #GTH2025 in Lausanne with Caterina, Jean and Alex! Jean has already presented his study, but don't miss Caterina tomorrow with the SynthoPlates! @caterinacasari.bsky.social @alexkzis.bsky.social #Science #congress #switzerland
February 20, 2025 at 5:42 PM
The lab is at #GTH2025 in Lausanne with Caterina, Jean and Alex! Jean has already presented his study, but don't miss Caterina tomorrow with the SynthoPlates! @caterinacasari.bsky.social @alexkzis.bsky.social #Science #congress #switzerland
The lab is at #GTH2025 in Lausanne with Caterina, Jean and Alex! Jean has already presented his study, but don't miss Caterina tomorrow with the SynthoPlates! @caterinacasari.bsky.social @alexkzis.bsky.social #Science #congress #switzerland
February 20, 2025 at 5:42 PM
The lab is at #GTH2025 in Lausanne with Caterina, Jean and Alex! Jean has already presented his study, but don't miss Caterina tomorrow with the SynthoPlates! @caterinacasari.bsky.social @alexkzis.bsky.social #Science #congress #switzerland