New content online:

📣Our new paper is out in Science Immunology.

Yuki Masuo revealed two distinct subsets of peripheral helper T (Tph) cells in #RheumatoidArthritis.
@chimomonga.bsky.social has nicely illustrated Tph-cell life.

doi.org/10.1126/scii...
@sciimmunology.bsky.social
@yuki-masuo.bsky.social

Another publication in Science Immunology. We revealed that stem-like peripheral helper T (Tph) cells self-renew, proliferate, and sustain the pathogenesis of #RheumatoidArthritis in the synovium.
doi.org/10.1126/scii...
@sciimmunology.bsky.social
‪@ashbi-kyotou.bsky.social‬
@yuki-masuo.bsky.social‬

www.science.org/doi/10.1126/...

“IGFL2 gene expression was specifically ⬆️ in #TPH cells in synovial tissue and fluid samples of patients with #RA. IGFL2 enhanced both TGF-β–induced production of CXCL13 by CD4 T cells and ⬆️ a shift in monocyte gene expression similar to pathogenic ones.”
#arthritis

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!

wwwscience.org/toc/sciimmun...

A primate-specific cytokine, IGFL2, produced by helper T cells in rheumatoid arthritis joints, has been identified as a potential marker of disease activity and a target for new therapies. doi.org/g9vwcj

Our study on immune responses in synovial tissue of patients with rheumatoid arthritis reveals the involvement of an evolutionary novel cytokine IGFL2 in the pathogenesis.

@sciimmunology.bsky.social
doi.org/10.1126/scii...

FOCIS also wants to congratulate the 2025 recipient of the British Society for Immunology (BSI) Poster Prize Award - Yuki Masuo, MD 👏

#FOCIS2025